2004
DOI: 10.1038/sj.embor.7400074
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DJ‐1 has a role in antioxidative stress to prevent cell death

Abstract: Deletion and point (L166P) mutations of DJ-1 have recently been shown to be responsible for the onset of familial Parkinson's disease (PD, PARK7). The aim of this study was to determine the role of DJ-1 in PD. We first found that DJ-1 eliminated hydrogen peroxide in vitro by oxidizing itself. We then found that DJ-1 knockdown by short interfering RNA rendered SH-SY5Y neuroblastoma cells susceptible to hydrogen peroxide-, MPP þ -or 6-hydroxydopamine-induced cell death and that cells harbouring mutant forms of D… Show more

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Cited by 788 publications
(624 citation statements)
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“…The function of the DJ-1 protein is not completely known, but the protein may be involved in the oxidative stress response pathway as an antioxidant protein [242] or as a scavenger [243].…”
Section: Dj-1 (Park7)mentioning
confidence: 99%
“…The function of the DJ-1 protein is not completely known, but the protein may be involved in the oxidative stress response pathway as an antioxidant protein [242] or as a scavenger [243].…”
Section: Dj-1 (Park7)mentioning
confidence: 99%
“…WT DJͲ1 appears to exert an antioxidant function [265Ͳ268], while deletions and point mutations in the DJͲ1 gene cause a loss of its physiological function and therefore, lead to neurodegeneration in rare families [146, 269Ͳ271]. Knockdown of DJͲ1 by siRNA in SHͲSY5Y human neuroblastoma cell line, enhanced susceptibility to several oxidative insults, including H 2 O 2 , MPP + and 6ͲOHDA [270]. Reciprocally, DJͲ1 overexpression in these cells resulted in increased resistance to these insults and reduced intracellular ROS formation [272].…”
Section: Djǧ1mentioning
confidence: 99%
“…DJ-1 was first identified by our group as a novel oncogene product [1] and was later found to be a causative gene product of a familial form of PD, PARK7 [2]. DJ-1 plays roles in transcriptional regulation [3][4][5][6][7][8] and anti-oxidative stress reaction [9][10][11][12], and loss of its function is thought to affect the onset of PD. DJ-1 has three cysteines at amino acid numbers 46, 53 and 106 (C46, C53 and C106, respectively).…”
Section: Introductionmentioning
confidence: 99%