DKK3 expression is correlated with poorer prognosis in head and neck squamous cell carcinoma: A bioinformatics study based on the TCGA database

Katase, Naoki; Nishimatsu, Shin-ichiro; Yamauchi, Akira; Okano, Shinji; Fujita, Shuichi

doi:10.1016/j.job.2023.09.002

Cited by 2 publications

(1 citation statement)

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“…DKK-3 stimulates processes that contribute to malignancy, which include cell-autonomous effects on cell proliferation, migration and invasion. High-level expression of DKK-3 is associated with chemoresistance and tumor volume progression in HNSCC [ 56 , 58 ], pancreatic [ 57 ] and esophageal cancer [ 10 ], and with poorer outcomes in HNSCC and esophageal cancer patients [ 10 , 70 ].…”

Section: Dkk-3 Has a Dual Role In Cancer As Either A Tumor Suppressor...mentioning

confidence: 99%

The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer

Mourtada,

Thibaudeau,

Wasylyk

et al. 2023

Cells

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The human Dickkopf (DKK) family includes four main secreted proteins, DKK-1, DKK-2, DKK-3, and DKK-4, as well as the DKK-3 related protein soggy (Sgy-1 or DKKL1). These glycoproteins play crucial roles in various biological processes, and especially modulation of the Wnt signaling pathway. DKK-3 is distinct, with its multifaceted roles in development, stem cell differentiation and tissue homeostasis. Intriguingly, DKK-3 appears to have immunomodulatory functions and a complex role in cancer, acting as either a tumor suppressor or an oncogene, depending on the context. DKK-3 is a promising diagnostic and therapeutic target that can be modulated by epigenetic reactivation, gene therapy and DKK-3-blocking agents. However, further research is needed to optimize DKK-3-based therapies. In this review, we comprehensively describe the known functions of DKK-3 and highlight the importance of context in understanding and exploiting its roles in health and disease.

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Section: Dkk-3 Has a Dual Role In Cancer As Either A Tumor Suppressor...mentioning

confidence: 99%

The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer

Mourtada,

Thibaudeau,

Wasylyk

et al. 2023

Cells

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Practical Consensus Guidelines on the Use of Cetuximab in Head and Neck Squamous Cell Carcinoma (HNSCC)

Parikh,

Biswas,

Dhamne

et al. 2024

South Asian J Cancer

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Head and neck squamous cell carcinoma (HNSCC) is the most common malignancy group in India and several other low- and middle-income countries. Currently, majority of the patients present in advanced stage where systemic therapy is standard of care. Multiple relapses are also not uncommon. Almost all HNSCC tumors have epidermal growth factor receptor (EGFR) overexpression, making an attractive target. Cetuximab is the most successful method to target EGFR in HNSCC. After decades of its use, it still is a prominent part of the current management guidelines. Since other agents have also been proven to be useful, we felt it was necessary to develop a real-world consensus guideline to help the decision-making process among the community oncologists. Our expert committee therefore put together currently available data, insights from their real-world clinical practice, and voted to arrive at a consensus. These consensus guidelines represent how cetuximab should be used today in the management of HNSCC.

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DKK3 expression is correlated with poorer prognosis in head and neck squamous cell carcinoma: A bioinformatics study based on the TCGA database

Cited by 2 publications

References 60 publications

The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer

The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer

Practical Consensus Guidelines on the Use of Cetuximab in Head and Neck Squamous Cell Carcinoma (HNSCC)

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