DL 717‐IT: a non‐hormonal agent for the control of fertility in the bitch

Abstract

The development of a new class of non‐hormonal contragestational agents provided a derivative, 2‐(4‐chlorophenyl)‐striazole|5,1‐alisoquinoline (DL 717‐IT or L 12717), with the qualities needed for application in the veterinary field as a post‐coital pregnancy‐terminating agent. Single intramuscular injections of this compound arrest pregnancy over a wide period of gestation in the bitch. A dose of 2.5 mg/kg was found to be very well tolerated and highly effective (100 per cent) when administered between the day of mating and the 15th day of pregnancy. The desired effect was not accompanied by uterine disorders or other unwanted effects. This non‐hormonal agent appears to have several real advantages over the only other drugs (oestrogens) available in veterinary practice for the termination of unwanted pregnancies in bitches.