dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity

Esterberg, Robert; Fritz, Andreas

doi:10.1016/j.ydbio.2008.10.017

Cited by 58 publications

(69 citation statements)

References 87 publications

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“…Specification of the PPE necessitates complete inhibition of BMP activity after gastrulation (Kwon et al, 2010). This inhibition of BMP signalling has previously been postulated to be mediated by an antagonistic role of Cvl2 on BMP signalling (Esterberg and Fritz, 2009). That study suggested that the functionally redundant Distalless transcription factors Dlx3b and Dlx4b, which are PPE markers, activate the expression of cvl2 in the PPE.…”

Section: Temporal and Spatial Analysis Of The Formation Of Distinct Bmentioning

confidence: 93%

A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border

2013

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SUMMARYDuring ectodermal patterning the neural crest and preplacodal ectoderm are specified in adjacent domains at the neural plate border. BMP signalling is required for specification of both tissues, but how it is spatially and temporally regulated to achieve this is not understood. Here, using a transgenic zebrafish BMP reporter line in conjunction with double-fluorescent in situ hybridisation, we show that, at the beginning of neurulation, the ventral-to-dorsal gradient of BMP activity evolves into two distinct domains at the neural plate border: one coinciding with the neural crest and the other abutting the epidermis. In between is a region devoid of BMP activity, which is specified as the preplacodal ectoderm. We identify the ligands required for these domains of BMP activity. We show that the BMP-interacting protein Crossveinless 2 is expressed in the BMP activity domains and is under the control of BMP signalling. We establish that Crossveinless 2 functions at this time in a positive-feedback loop to locally enhance BMP activity, and show that it is required for neural crest fate. We further demonstrate that the Distal-less transcription factors Dlx3b and Dlx4b, which are expressed in the preplacodal ectoderm, are required for the expression of a cell-autonomous BMP inhibitor, Bambi-b, which can explain the specific absence of BMP activity in the preplacodal ectoderm. Taken together, our data define a BMP regulatory network that controls cell fate decisions at the neural plate border.

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Section: Temporal and Spatial Analysis Of The Formation Of Distinct Bmentioning

confidence: 93%

A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border

2013

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“…Conserved signalling pathways control different cell behaviours according to elongation modes Despite these differences, there is an apparent conserved requirement for both FGF and Wnt signalling pathway components and downstream Cdx and Brachyury transcription factors for posterior body elongation across a range of vertebrates Esterberg and Fritz, 2009;Marlow et al, 2004;Row and Kimelman, 2009;Shimizu et al, 2005;Thorpe, 2005;Yang and Thorpe, 2011). Brachyury is also expressed in the tailbud during elongation in dogfish and lamprey embryos (Sauka-Spengler et al, 2003).…”

Section: Zebrafish Posterior Body Elongation Is Not Driven By Posterimentioning

confidence: 99%

Species tailoured contribution of volumetric growth and tissue convergence to posterior body elongation in vertebrates

et al. 2016

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Posterior body elongation is a widespread mechanism propelling the generation of the metazoan body plan. The posterior growth model predicts that a posterior growth zone generates sufficient tissue volume to elongate the posterior body. However, there are energy supply-related differences between vertebrates in the degree to which growth occurs concomitantly with embryogenesis. By applying a multi-scalar morphometric analysis in zebrafish embryos, we show that posterior body elongation is generated by an influx of cells from lateral regions, by convergence-extension of cells as they exit the tailbud, and finally by a late volumetric growth in the spinal cord and notochord. Importantly, the unsegmented region does not generate additional tissue volume. Fibroblast growth factor inhibition blocks tissue convergence rather than volumetric growth, showing that a conserved molecular mechanism can control convergent morphogenesis through different cell behaviours. Finally, via a comparative morphometric analysis in lamprey, dogfish, zebrafish and mouse, we propose that elongation via posterior volumetric growth is linked to increased energy supply and is associated with an overall increase in volumetric growth and elongation.

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“…Drosophila, zebrafish and mammalian Cv2 proteins can also inhibit signaling in some, but not all, in vitro assays (e.g. Binnerts et al, 2004;Esterberg and Fritz, 2009;Harada et al, 2008;Kelley et al, 2009;Moser et al, 2003;Serpe et al, 2008;.…”

Section: Context-dependent Effects On Bmp Signal Reception: Crossveinmentioning

confidence: 99%

The extracellular regulation of bone morphogenetic protein signaling

2009

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In many cases, the level, positioning and timing of signaling through the bone morphogenetic protein (BMP) pathway are regulated by molecules that bind BMP ligands in the extracellular space. Whereas many BMP-binding proteins inhibit signaling by sequestering BMPs from their receptors, other BMP-binding proteins cause remarkably context-specific gains or losses in signaling. Here, we review recent findings and hypotheses on the complex mechanisms that lead to these effects, with data from developing systems, biochemical analyses and mathematical modeling.

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dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity

Cited by 58 publications

References 87 publications

A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border

A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border

Species tailoured contribution of volumetric growth and tissue convergence to posterior body elongation in vertebrates

The extracellular regulation of bone morphogenetic protein signaling

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