DM and PCa risk: a mendelian randomization analysis

Abstract

Introduction: Some studies have shown that there is a certain relationship between diabetes mellitus (DM) and prostate cancer (PCa), but the specific relationship is still inconclusive. This study will investigate the potential relationship from the perspective of Mendelian randomization (MR) research. Method: We downloaded relevant data of "diabetes" and "prostate cancer" from the IEU OpenGWAS project database, performing three different methods to conduct MR analysis, and carried out sensitivity analysis for verification. Results: The results indicated that DM was an independent risk factor for PCa. The OR values obtained through the inverse variance weighted (IVW) method in this study was: OR = 1.018 (95% CI, 1.004 to 1.032), P = 0.014. Conclusion: Through our research, we found that DM could increase the incidence rate of PCa.