DMBA induced mammary tumor study of Phyto-fabricated sliver nanoparticles from Russelia Equisetiformis flower extract in rat

Abstract

The mammary tumor is the world's most frequent ailment, and it is substantially more common in women. There are several forms of treatment and care available in the globe for tumors, the most common of which being chemotherapy, radiation therapy, and surgery with lots of harmful responses. Cancer has been treated since ancient times by herbs with various herbs and metals. synthesized AgNPs-REEE were characterized by Analytical methods such as dynamic light scattering (DLS), Zeta potential, scanning electron microscopy (SEM), energy dispersive spectroscopy (EDX) and Dynamic Light Scattering (DLS).All of the animals in this study had tumors caused by DMBA Apart from the vehicle control group, and they were divided into different groups such as only DMBA(7,12-dimethylbenz[a]anthracene) induced group, treatment group of ethanolic extract of Russelia equisetiformis (REEE) flower and sliver nanoparticles of ethanolic extract of Russelia equisetiformis (REEE) flower and sliver nanoparticles of ethanolic extract (AgNPs -REEE).the dose were decide by acute toxicity study. After compaction treatment time all animal were sacrifices and evaluate parameter like tumor weight, Tumor volume, biochemical parameter, hormonal assay and histopathology of breast tumor. It is observed that the size distribution of AgNPs ranges from 50 to 950 nm.