DMSA-Coated Cubic Iron Oxide Nanoparticles as Potential Therapeutic Agents

Abstract

Aim: Superparamagnetic cubic iron oxide nanoparticles (IONPs) were synthesized and functionalized with meso-2,3-dimercaptosuccinic acid (DMSA) as a potential agent for cancer treatment. Methods: Monodisperse cubic IONPs with a high value of saturation magnetization were synthesized by thermal decomposition method and functionalized with DMSA via ligand exchange reaction, and their cytotoxic effects on HeLa cells were investigated. Results: DMSA functionalized cubic IONPs with an edge length of 24.5 ± 1.9 nm had a specific absorption rate value of 197.4 W/gFe (15.95 kA/m and 488 kHz) and showed slight cytotoxicity on HeLa cells when incubated with 3.3 × 1010, 6.6 × 1010 and 9.9 × 1010 NP/mL for 24, 48 and 72 h. Conclusion: To the best of our knowledge, this is the first study to investigate both the cytotoxic effects of DMSA-coated cubic IONPs on HeLa cells and hyperthermia performance of these nanoparticles.

Synthesis of Biogenic Hematite Nanocubes as Recyclable Dark Fenton-like Catalysts at Neutral pH and Plant Growth Applications of Degraded Waste Water

“…Higher ionization in an alkaline medium leads to ionized species and, as a result, increased repulsion from negatively charged species, resulting in colloidal stability. 35 , 36…”

Multimodal Radiobioconjugates of Magnetic Nanoparticles Labeled with ⁴⁴Sc and ⁴⁷Sc for Theranostic Application

“…Zeta potentials (ζ) provide information about the charge distribution on the surface of the nanoconjugates. In general, absolute zeta potential values above 30 mV provide good stability and about 20 mV provide only short term stability, which is generally considered as a threshold value for the electrostatic stabilization, values in the range -5 mV to +5 mV indicate fast aggregation [31,32]. We performed zeta potential measurements at three various pH (pH=2, pH=7 and pH=12), where at 2 and 12 the hydrodynamic diameter of the NPs did not show any significant changes.…”

A guide to the design of magnetic particle imaging tracers for biomedical applications

“…26,84,129 In a recent study conducted ▣Citoglu et al, it was reported that 25 nm cubic SPIONs coated with DMSA possess a higher magnetisation compared to unmodified SPIONs (coated with decanoic acid). 130 The increase in M sat (DMSA coated = 89.6 emu g −1 and unmodified = 74.2 emu g −1 ) is hypothesised to be due the disulfide bonds from the DMSA molecule that can shorten the distance between MNPs and hence improve the magnetic properties (Fig. 7).…”

“…7). 130 Furthermore, the free thiol and carboxylic groups of DMSA can be conjugated with antibodies, proteins or other drugs for biomedical applications. 129 However, Liu et al reported that DMSA coated MNPs could degrade into iron ions in an acidic environment inside the lysosome.…”

“…131 This degradation will result in high concentration of iron accumulated in the body that can produce reactive oxygen species and thus lead to cell toxicity. 130 As a result, these DMSA coated NPs can be used in therapeutic treatment to target cancerous cells in mildly acidic environments only (i.e., 6.4 pH − 7.0 pH). Therefore, DMSA coated magnetic nanoparticles present great potential for uses in therapeutic treatments such as cancers and anaemia.…”