DNA adducts and mutations induced by ethylating agents in λlacZ transgenic mice

Mientjes, Edwin; Wolf, E.; Luiten-Schuite, A.; Borsboom, Y.; Bergmans, Angela; Delft, Joost van; Lohman, P.H.M.; Baan, R.A.

doi:10.1016/s0165-1161(96)90025-4

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“…The role of DSB repair, NHEJ in particular, in the aging process has also been extensively studied, and disruption of genes involved in this pathway leads to progressive and permanent neuronal damage and impairing cognitive and motor functions (Madabhushi et al, 2014;Alt and Schwer, 2018;Khan et al, 2018). Emerging findings suggest that an imbalance between DSBs accumulation and repair in brain contributes to neuronal damage, impaired learning, and memory and has Oh et al, 2021) • (++) (Kim et al, 2006;Brégeon and Doetsch, 2011) • (-) (Liu et al, 1995;Charlet-Berguerand et al, 2006;Kornberg, 2007) N.D. Y (Mientjes et al, 1996;Wang et al, 2016) O4-ethylthymidine (O4-ET), smoke-related adduct…”

Section: Dna Repair Pathways That Are Activated In Postmitotic Neuronsmentioning

confidence: 99%

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Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases

Cao

Liu

et al. 2022

Front. Cell. Neurosci.

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Most of the neurodegenerative diseases and aging are associated with reactive oxygen species (ROS) or other intracellular damaging agents that challenge the genome integrity of the neurons. As most of the mature neurons stay in G0/G1 phase, replication-uncoupled DNA repair pathways including BER, NER, SSBR, and NHEJ, are pivotal, efficient, and economic mechanisms to maintain genomic stability without reactivating cell cycle. In these progresses, polymerases are prominent, not only because they are responsible for both sensing and repairing damages, but also for their more diversified roles depending on the cell cycle phase and damage types. In this review, we summarized recent knowledge on the structural and biochemical properties of distinct polymerases, including DNA and RNA polymerases, which are known to be expressed and active in nervous system; the biological relevance of these polymerases and their interactors with neuronal degeneration would be most graphically illustrated by the neurological abnormalities observed in patients with hereditary diseases associated with defects in DNA repair; furthermore, the vicious cycle of the trinucleotide repeat (TNR) and impaired DNA repair pathway is also discussed. Unraveling the mechanisms and contextual basis of the role of the polymerases in DNA damage response and repair will promote our understanding about how long-lived postmitotic cells cope with DNA lesions, and why disrupted DNA repair contributes to disease origin, despite the diversity of mutations in genes. This knowledge may lead to new insight into the development of targeted intervention for neurodegenerative diseases.

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Section: Dna Repair Pathways That Are Activated In Postmitotic Neuronsmentioning

confidence: 99%

“…Unrepaired (Den Engelse et al, 1987;Bronstein et al, 1992) Weak pausing (You et al, 2014) (-) (Xu L. et al, 2017) N.D. N.D. Quick bypass and transcriptional mutagenesis (You et al, 2014) Y (Mientjes et al, 1996;Wang et al, 2016) N2-(1-Carboxyethyl)-guanine (CEG)…”

Section: Dna Repair Pathways That Are Activated In Postmitotic Neuronsmentioning

confidence: 99%

Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases

Cao

Liu

et al. 2022

Front. Cell. Neurosci.

View full text Add to dashboard Cite

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DNA adducts and mutations induced by ethylating agents in λlacZ transgenic mice

Cited by 1 publication

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Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases

Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases

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