2008
DOI: 10.1007/978-1-4020-6829-4_5
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DNA-Based Nanostructures: Changes of Mechanical Properties of DNA upon Ligand Binding

Abstract: The formation of DNA-based nanostructures involves the binding of different kinds of ligands to DNA as well as the interaction of DNA molecules with each other. Complex formation between ligand and DNA can alter physicochemical properties of the DNA molecule. In the present work, the accessibility of DNAligand complexes to cleavage by DNase I are considered, and the exact algorithms for analysis of diagrams of DNase I footprinting for ligand-DNA complexes are obtained. Changes of mechanical properties of the D… Show more

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