DNA-binding activity is associated with purified myb proteins from AMV and E26 viruses and is temperature-sensitive for E26 ts mutants

trans activation of gene expression by v-myb.

“…Several characteristics of myb-encoded proteins suggest that they may serve a regulatory role within cells. These proteins are present within the cell nucleus, have short half-lives, and exhibit a DNA-binding activity in vitro (5,24,34). Furthermore, v-myb protein overexpressed in Escherichia coli has recently been shown to possess an intrinsic, sequencespecific DNA-binding activity (3).…”

Restriction fragment length polymorphisms of L-myc and myb in human leukaemia and lymphoma in relation to age-selected controls

“…C-myb is the transforming gene of the avian myeloblastosis virus (AMV). The product of the gene is a nuclear DNA binding protein (Moelling et al, 1985). It is expressed in haematopoetic cells of all lineages (Westin et al, 1982) and for this reason may play a role in the differentiation and transformation of these cells.…”

Human proto-oncogene N-myc encodes nuclear proteins that bind DNA.

“…N-myc is a gene whose amplification has been demonstrated in three forms of malignant human tumors-neuroblastoma (23,28,39), retinoblastoma (27), and small cell carcinoma of the lung (30). In the absence of amplification, the gene is expressed in a limited variety of cells and tissues (17,40,48), but its function in either normal or malignant cells is not known.…”