DNA binding and DNA cleavage studies of a water soluble cobalt(II) complex containing dinitrogen Schiff base ligand: The effect of metal on the mode of binding

Dioxygen Binding by Cobalt(II) Complexes of 8,8'-bis(aminomethyl)-2,2'-biquinoline

“…These observations are indicative of a process in which the interaction with dioxygen is facilitated by the presence of a strongly ligating solvent such as DMF, with the reaction in methanol being slow and incomplete. These observations parallel those previously reported for the interaction of [Co(salen)] with dioxygen [8,9]. When dinitrogen was bubbled through the red-brown DMF solution which had been obtained after oxygenation, these colour changes were reversed and a green solution was obtained.…”

“…Low-spin complexes of cobalt(II) commonly exhibit square planar four coordinate or square pyramidal five coordinate geometries, and the magnetic moments for these compounds are typically in the range 2.0 -3.0 B.M. at room temperature, although a very wide range of values have been reported [8,14,15]. We have previously demonstrated that the ligand L may form six-coordinate ([MnLC1 2 ]) and five-coordinate ([CuLCI]CI) complexes [13].…”

“…In the solid state [Co(salen)] reversibly absorbs dioxygen at a ratio of 2:1 to give a compound in which the dioxygen bridges the cobalt atoms of two coplanar complex molecules; i.e. approaching the peroxide-bridged dicobalt(III) structure [8,9]. In N,Ndimethylformamide (DMF) solution, the complex also reacts reversibly with dioxygen to form a peroxo-bridged dicobalt(III) complex [10].…”

Schiff bases: An emerging potent class of pharmaceuticals

“…DNA binding is the critical step for DNA activity. The complexes make these compounds effective and stereospecific catalysts for oxidation, reduction and hydrolysis and they show biological activity, and other transformations of organic and inorganic chemistry (Shahabadi et al, 2010). It is well known that some drugs have higher activity when administered as metal complexes than as free ligands.…”

Synthesis, Characterization and Interaction of Drug Based Cobalt (II) Complex with Herring Sperm DNA and Biological Activity

“…Many coordination compounds are able to bind DNA as structural probes[1], DNA foot printing [2], DNA cleaving agents [3][4] and as potential anticancer drugs [5][6]. It is generally believed that many anticancer, antiviral, and antiseptic agents take action through binding DNA [4,[7][8], since the interaction between small molecules and DNA can often cause DNA damage in cancer cells, blocking the division of cancer cells and resulting in cell death [9][10][11]. Many studies indicate that transition metal complexes can bind to DNA via both covalent (replacement of labile coordinating ligand by nitrogen base of DNA (i.e.…”