DNA Binding and its Degradation by the Neurotransmitter Serotonin and its Structural Analogues Melatonin and Tryptophan: Putative Neurotoxic Mechanism

Rehmani, Nida; Farhan, Mohd; Hadi, S. M.

doi:10.4172/1747-0862.1000223

Cited by 5 publications

(3 citation statements)

References 53 publications

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“…Although sertraline's interactions with genetic material have not been investigated in vivo, sertraline does have affinity for the minor groove of DNA 60 , indicating its potential to interact with an organism's genetic material once inside the cell. Interestingly, serotonin can act as a pro-oxidant of DNA 61 and induce double strand breaks in the presence of copper ions 62 . Thus, we hypothesized www.nature.com/scientificreports www.nature.com/scientificreports/ that sertraline, or one of its metabolic breakdown products, might induce oxidative DNA damage that could eventually lead to the formation of double-strand breaks.…”

Section: Sertraline Affects Drosophila Development Independently Of Smentioning

confidence: 99%

Sertraline induces DNA damage and cellular toxicity in Drosophila that can be ameliorated by antioxidants

Jajoo

Donlon

Shnayder

et al. 2020

Sci Rep

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Sertraline hydrochloride is a commonly prescribed antidepressant medication that acts by amplifying serotonin signaling. Numerous studies have suggested that children of women taking sertraline during pregnancy have an increased risk of developmental defects. Resolving the degree of risk for human fetuses requires comprehensive knowledge of the pathways affected by this drug. We utilized a Drosophila melanogaster model system to assess the effects of sertraline throughout development. Ingestion of sertraline by females did not affect their fecundity or embryogenesis in their progeny. However, larvae that consumed sertraline experienced delayed developmental progression and reduced survival at all stages of development. Genetic experiments showed that these effects were mostly independent of aberrant extracellular serotonin levels. Using an ex vivo imaginal disc culture system, we showed that mitotically active sertraline-treated tissues accumulate DNA double-strand breaks and undergo apoptosis at increased frequencies. Remarkably, the sertraline-induced genotoxicity was partially rescued by co-incubation with ascorbic acid, suggesting that sertraline induces oxidative DNA damage. These findings may have implications for the biomedicine of sertraline-induced birth defects.

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Section: Sertraline Affects Drosophila Development Independently Of Smentioning

confidence: 99%

Sertraline induces DNA damage and cellular toxicity in Drosophila that can be ameliorated by antioxidants

Jajoo

Donlon

Shnayder

et al. 2020

Sci Rep

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“…Under optimum conditions, enatioseparation was observed for all of the tested amino acids using PNA-SWCNTs monolithic column [ 47 ]. Tryptophan is one of the essential building blocks of proteins and analogues for serotonin and melatonin which improves the mood and sleep [ 121 ]. The pharmaceutical use of tryptophan is banned due to the severe side effects [ 122 ].…”

Section: Swcnts and Mwcnts For Chiral Separation In Biological Actmentioning

confidence: 99%

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

et al. 2017

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Carbon nanotubes (CNTs) possess unique mechanical, physical, electrical and absorbability properties coupled with their nanometer dimensional scale that renders them extremely valuable for applications in many fields including nanotechnology and chromatographic separation. The aim of this review is to provide an updated overview about the applications of CNTs in chiral and achiral separations of pharmaceuticals, biologics and chemicals. Chiral single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) have been directly applied for the enantioseparation of pharmaceuticals and biologicals by using them as stationary or pseudostationary phases in chromatographic separation techniques such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and gas chromatography (GC). Achiral MWCNTs have been used for achiral separations as efficient sorbent objects in solid-phase extraction techniques of biochemicals and drugs. Achiral SWCNTs have been applied in achiral separation of biological samples. Achiral SWCNTs and MWCNTs have been also successfully used to separate achiral mixtures of pharmaceuticals and chemicals. Collectively, functionalized CNTs have been indirectly applied in separation science by enhancing the enantioseparation of different chiral selectors whereas non-functionalized CNTs have shown efficient capabilities for chiral separations by using techniques such as encapsulation or immobilization in polymer monolithic columns.

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“…Under optimum conditions, enatioseparation was observed for all of the tested amino acids using PNA-SWCNTs monolithic column [47]. Tryptophan is one of the essential building blocks of proteins and analogues for serotonin and melatonin which improves the mood and sleep [120]. The pharmaceutical use of tryptophan is banned due to the severe side effects [121].…”

Section: Swcnts and Mwcnts For Chiral Separation In Biologicsmentioning

confidence: 99%

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

Hemasa

Naumovski

Maher

et al. 2017

Preprint

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Carbon nanotubes (CNTs) possess unique mechanical, physical, electrical and absorbability properties coupled with their nanometer dimensional scale that renders them extremely valuable for applications in many fields including nanotechnology and chromatographic separation. The aim of this review is to provide an updated overview about the applications of CNTs in chiral and achiral separations of pharmaceuticals, biologics and chemicals. Chiral SWCNTs and MWCNTs have been directly applied for the enantioseparation of pharmaceuticals and biologicals by using them as stationary or pseudostationary phases in chromatographic separation techniques such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and gas chromatography (GC). Achiral MWCNTs have been used for achiral separations as efficient sorbent objects in solid-phase extraction techniques of biochemicals and drugs. Achiral SWCNTs have been applied in achiral separation of biological samples. Achiral SWCNTs and MWCNTs have been also successfully used to separate achiral mixtures of pharmaceuticals and chemicals. Collectively, functionalized CNTs have been indirectly applied in separation science by enhancing the enantioseparation of different chiral selectors whereas, non-functionalized CNTs have shown efficient capabilities for chiral separations by using techniques such as encapsulation or immobilization in polymer monolithic columns.

show abstract

DNA Binding and its Degradation by the Neurotransmitter Serotonin and its Structural Analogues Melatonin and Tryptophan: Putative Neurotoxic Mechanism

Cited by 5 publications

References 53 publications

Sertraline induces DNA damage and cellular toxicity in Drosophila that can be ameliorated by antioxidants

Sertraline induces DNA damage and cellular toxicity in Drosophila that can be ameliorated by antioxidants

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

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