DNA binding and nuclease activity of a one-dimensional heterometallic nitrosyl complex

Selim,; Chowdhury, Sujoy Roy; Mukherjea, Kalyan K.

doi:10.1016/j.ijbiomac.2007.07.016

Cited by 34 publications

(8 citation statements)

References 52 publications

(45 reference statements)

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“…As shown in Fig. 9, BHA exhibited a trivial effect on DNA damage because the migration of Form I changed insignificantly with increasing concentration of BHA [51,52], and both Forms II and III cannot be observed. These results together with CD and Fig.…”

Section: Dna Cleavage Activity Of Bhamentioning

confidence: 90%

Intercalation binding of food antioxidant butylated hydroxyanisole to calf thymus DNA

Wang

Zhang

Pan

et al. 2014

Journal of Photochemistry and Photobiology B: Biology

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Section: Dna Cleavage Activity Of Bhamentioning

confidence: 90%

Intercalation binding of food antioxidant butylated hydroxyanisole to calf thymus DNA

Wang

Zhang

Pan

et al. 2014

Journal of Photochemistry and Photobiology B: Biology

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“…Ethidium bromide (EB) is a well‐known intercalator, which can be used as a spectral probe to establish the mode of binding of small molecules to double‐helical DNA . EB is a weakly fluorescent compound, but its fluorescence is largely increased on binding of DNA by intercalative mode . The emission intensity of EB bound DNA may again decrease when a third compound (metal complex) intercalates within the DNA base pairs by displacing EB.…”

Section: Resultsmentioning

confidence: 99%

A Multifunctional Biomimicking Oxidovanadium(V) Complex: Synthesis, DFT Calculations, Bromo‐peroxidation and DNA Nuclease Activities

et al. 2018

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An oxidovanadium(V) complex [VO(SGly)(bpy)]ClO4 (H2SGly=N‐(2‐hydroxybenzyl)‐L‐glycine; bpy=2,2′‐bipyridine) was synthesized and characterized by spectroscopic studies (IR, UV‐vis, ESI‐MS). The theoretical structure of the complex was optimized by density functional theory (DFT) calculations. The multifunctionality of this oxidovanadium complex was demonstrated by the application of it as a catalyst in peroxidative bromination of single‐pot conversion of phenol red to bromophenol blue, whereas its nuclease activity was established by DNA cleavage. The interaction of this oxidovanadium complex with DNA was studied by various physicochemical tools like UV‐vis, fluorescence, and viscosity measurement studies. The intrinsic binding constant of the complex with DNA was determined spectrophotometrically and calculated to be (2.3 ± 0.02) x 104 M−1. The spectroscopic studies and the viscosity measurements indicate that the complex binds to the groove of CT‐DNA, but whether to the major or minor groove that was not established. The extent of vanadium complex induced DNA cleavage was studied by gel electrophoresis techniques. The complex was found to promote cleavage of pUC19 plasmid DNA from the super coiled (SC DNA) form I to nicked coiled (NC DNA) relaxed form II.

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“…4b) [19] and {Ba(bpy) 2 (µ-SCN)(µ-NCS)} n [22] A cis-arrangement of the oligopyridines at the group 2 metal centre is found in {Sr(phen) 2 (dmf) 2 (µ- (Fig. 4c), [23,24,25] and the closely related complex [26] The structure of {Ba(bpy) 2 (µ-I) 2 } n shows alternating up-down cis-Ba(bpy) 2 units reminiscent of the Type 2 chain (Fig. 4d).…”

Section: Group 2 Elementsmentioning

confidence: 98%

‘Simple’ Oligopyridine Complexes – Sources of Unexpected Structural Diversity

Constable

Housecroft

2020

Aust. J. Chem.

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The simple formulae often presented for main-group metal complexes of oligopyridines (typically 2,2′-bipyridine, 1,10-phenanthroline, and 2,2′:6′,2″-terpyridine) hide a wide variety of polymeric solid-state structures. We present an overview of these structures and reveal a plethora of 1D chains, including ladder assemblies, and 2D networks. In most assemblies, the polymeric backbone or network is defined by the metal atoms and bridging ligands other than oligopyridines. The heterocyclic ligands typically feature as peripheral decorations, often engaging in face-to-face supramolecular π-stacking interactions which define the assembly of the crystal. In 1D coordination polymers, three types of decoration predominate which we have defined as Type 1 (all the oligopyridines on the same side and π-stacked), Type 2 (alternating arrangement of oligopyridines), and Type 3 (a pairwise alternating structure).

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DNA binding and nuclease activity of a one-dimensional heterometallic nitrosyl complex

Cited by 34 publications

References 52 publications

Intercalation binding of food antioxidant butylated hydroxyanisole to calf thymus DNA

Intercalation binding of food antioxidant butylated hydroxyanisole to calf thymus DNA

A Multifunctional Biomimicking Oxidovanadium(V) Complex: Synthesis, DFT Calculations, Bromo‐peroxidation and DNA Nuclease Activities

‘Simple’ Oligopyridine Complexes – Sources of Unexpected Structural Diversity

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