DNA- Binding, Biological Activities and Chemical Composition of Wild Growing Epilobium angustifolium L. Extracts from Canakkale, Turkey

Sayik, Aysema; Yusufoğlu, Ayşe; Açık, Leyla; Türker, Gülen; Aydın, Betül; Arslan, Leyla

doi:10.18596/jotcsa.319789

Cited by 18 publications

(21 citation statements)

References 51 publications

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“…The antioxidant activity of active ingredients of the promising extracts from C.vulgaris cultivated under 0.44 and 0.88 mg/L Zn and 0.158 and 0.316 mg/L Cu may be correlated with the presence of hydroxyl group and unsaturated bonds in the chemical structure of its compounds which show high ability for scavenging free radicals and prevent the oxidation processes, as shown in Table 9, the promising extract are rich with bioactive compounds as antioxidant compounds such as Milbemycin b, cyclononasiloxane, hexadecanoic acid, 10-octadecanoic acid, Tetrakis, cyclotrisiloxane. These observations were in agreement with the previously published results (Kadri et al, 2011;Abd El-Aty et al, 2014;Khurgain et al, 2017;Sayik et al, 2017). Also, the obtained results correlated with data in Table 5, there are strong correlation between the antioxidant activity of promising extracts (Table 6) and concentration of flavonoids and phenolic compounds in Table 5, the algae cultivated under 0.44 and 0.88 mg/L Zn produced 23.89 and 15.34 mg/g flavonoids and 53.76 and 60.16 mg/g phenolic content.…”

Section: Discussionsupporting

confidence: 94%

“…these compounds have high ability to inhibit microbial growth by its effect on microbe replication, microbe enzymes, cell membrane etc. as reported by Rollas and Kücükgüzel, 2007;Kalaisezhiyen and Sasikumar, 2012;Krishnaveni et al, 2014;Khurgain et al, 2017, Mebude andAdeniyi, 2017;Sayik et al, 2017. From the obtained data in Figure 1 , it is clear that the cytotoxicity pattern of the crude extract of C.vulgaris on both HCT 116 and HeLa cell lines is similar while differs on MCF-7. These results indicate that the effect of crude extract on HCT 116 and Hela cells is concentration dependant through the concentrations tested (1-1000 μg/mL).…”

Section: Discussionsupporting

confidence: 73%

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Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition

El-fayoumy¹,

Shanab²,

Shalaby³

2020

CMUJNS

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The aim of this work was to determine the biochemical compounds and evaluate the biological activities of Chlorella vulgaris cultivated under a biotic stress condition (various Zinc and Cupper conc.). The growth rate was recorded as well as determination of active compounds, pigments and defense enzymes, in addition to the biological activities as antioxidant, antimicrobial and anticancer. The obtained results revealed that, higher copper concentrations [0.632 mg /L (Cu)] showed an inhibitory effect to growth while 1.76 mg /L (Zn) enhanced growth which reached its maximum at 25 th day of cultivation. Furthermore, combination of 0.88mg/L (Zn) and 0.316mg /L (Cu) induced an increase in growth rate, catalase, tannins, lipid peroxidation and glutathione-S-transferase and a decrease in flavonoids, phenolic content, protein and antioxidant activity. Also, the results of antioxidant activity showed that, elevation of Zn conc. induced an augmentation of antioxidant activity either by DPPH(2, 2 diphenyl-1-picrylhydrazyl) or ABTS (2, 2'-azino-bis ethylbenzthiazoline-6-sulfonic acid), with maximum activity at 0.88 mg/L Zinc conc. (89.91%) even exceeded those of control (85.62%). While more elevated Zn conc. (1.76 mg/L) induced lower activity when compared with synthetic antioxidant standard (Butylated hydroxyl toluene, BHT). Concerning antimicrobial activity, Gram +ve bacteria, Staphylococcusaureus recorded moderate activity in sulfur-contained extract. Cytotoxicity of three cancer cell lines was inversely proportional to extracts conc. used, where the higher conc. (500µg/ml) showed the lowest cell viability of the tested cell lines which ranged from 22.06 to 69.89%. 0.316 mg/L (Cu) of conc. 500 µg/ml recorded the lowest

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 73%

Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition

El-fayoumy¹,

Shanab²,

Shalaby³

2020

CMUJNS

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“…These results may be correlated with the presence of bioactive compounds recorded in Table 7 as antioxidant, antimicrobial, anticancer, and antiviral compounds such as cyclohexasiloxane, dodecamethyl, cycloheptasiloxane, tetradecamethyl, 2-hexadecen-1-ol, 3,7,11,15-tetramethyl-, [r-[r*,r*-(e)]]-4h-1-benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-3,5-dihydroxy-7-methoxy-, 2-hexadecanol, hexadecanoic acid, and methyl ester. These observations were in agreement with the previously published results [ 84 , 88 , 90 , 91 ]. Also, the obtained results correlated with the data in Table 2 ; there is a strong correlation between the biological activity of the promising crude extract (0.3 g/l S) and the concentration of flavonoids (10.91 ± 0.72 mg of rutin/g DW), phenolic compounds (47.32 ± 0.58 mg gallic acid equivalent/g), and tannin (13.77 ± 0.58 mg tannic acid equivalent/g DW).…”

Section: Resultssupporting

confidence: 94%

Enhancement of active ingredients and biological activities of Nostoc linckia biomass cultivated under modified BG-110 medium composition

El-fayoumy

Shanab

Hassan

et al. 2021

Biomass Conv. Bioref.

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The current work aims to investigate the effect of abiotic stresses (nitrogen (N) and sulfur (S) [0.0 g/l, 1.5 g/l, 3 g/l, 6 g/l, and 12 g/l N and 0.0 g/l, 0.07 g/l, 0.15 g/l, 0.3 g/l, and 0.6 g/l S] and their combination [0.3 g/l S + 6 g/l N]) of axenic culture of Nostoc linckia on the production of secondary metabolites which induce different biological activities. Growth rate was measured by dry weight (DW) and optical density (OD) 550 nm . Additionally, phytochemical compounds, defense enzymes as well as antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(ethylbenzthiazoline-6-sulfonic acid) (ABTS ·+ ) radical assays of crude extracts (methylene chloride:methanol, 1:1) were evaluated. Based on antioxidant activity, four promising extracts were subjected to different biological activities such as anticancer, antimicrobial, and antiviral activities. The obtained results revealed that supplementation of external nitrogen source in the form of sodium nitrate was found to increase the total phycobiliprotein content by fivefold. Also, nitrogen depletion provoked significantly highest quantities of phenolic and flavonoid content and this has effects on biological activities of Nostoc linckia . Moreover, 0.3 g/l S was found to be the most effective extract exhibiting a significant increase in antioxidant activity based on DPPH and ABTS assays, respectively (88.18 ± 0.64% and 84.20 ± 1.01%). Furthermore, it recorded anticancer activity against HCT 116 cell line with IC 50 of 155 μg/ml. Moreover, this extract possessed a noticeable antibacterial potency (21.0 ± 1.0 as mm inhibition zone against Staphylococcus aureus and 19.3 ± 0.6 against Streptococcus mutans ). In addition, its antiviral activity against H 5 N 1 virus as a percentage of inhibition was 50% and 63.6% at a concentration of 7 μg/ml and 28 μg/ml, respectively, with cytotoxicity less than 7 μg/μl. GC-MS analysis recorded the presence of bioactive compounds exhibiting different biological activities. Therefore, the obtained results can represent valuable bioactive compounds with variable biological potencies.

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“…This compound was aza sterol that is plant hormonal components. It was antiandrogenic effective steroid derivatives that had antioxidant activity used for medicinal usage [22]. Sterols have anti-cancer activity and immune regulatory effects [23].…”

Section: Resultsmentioning

confidence: 99%

Isolation and identification of cholestane and dihydropyrene from Calophyllum inophyllum

Susanto

Aparamarta

Widjaja

et al. 2019

Heliyon

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The highest population of Calophyllum inophyllum is in Indonesia. One of the bioactive compound contained in C. inophyllum leave is cholestane. The extraction method was employed to obtain crude extract from these leaves. It was followed by identification of the bioactive compounds. The purpose of this research was to develop a process for isolating and identifying cholestane and dihydropyrene from methanolic extract of C. inophyllum leaves in high yield and purity. The effect of crude extract to non-polar solvent mass ratio and non-polar solvent types on the separation of the bioactive compounds were also systematically investigated. New compounds (trans-2-[2-(trifluoromethyl)phenyl]-10b,10c-dimethyl-10b, 10c-dihydropyrene and anti-4-aza-B-homo-5.alpha-cholestane-3-one) were also identified in C. inophyllum leaves. The successful separation was obtained by employing CS2 as the solvent and crude extract to CS2 mass ratio of 1/10 (g/g).

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DNA- Binding, Biological Activities and Chemical Composition of Wild Growing Epilobium angustifolium L. Extracts from Canakkale, Turkey

Cited by 18 publications

References 51 publications

Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition

Metabolomics and Biological activities of Chlorella vulgaris grown under modified growth medium (BG11) composition

Enhancement of active ingredients and biological activities of Nostoc linckia biomass cultivated under modified BG-110 medium composition

Isolation and identification of cholestane and dihydropyrene from Calophyllum inophyllum

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