DNA binding studies of the 2,10,16,24–tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds

Ballı, Zekeriya; Arslantaş, Ali; Solğun, Derya Güngördü; Ağırtaş, Mehmet Salih

doi:10.1007/s42452-020-2640-4

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…Ağırtaş et al. synthesized 2,10,16,24‐tetrakis (phenoxy 3 methoxy benzoic acid) phthalocyaninato) Co(II) and Cu(II) compounds and the complexes exhibited CT‐DNA binding activities [56] . Uslan and Sesalan synthesized bis[(1‐methylpyrrolidin‐2‐yl)methoxy] [phthalocyaninato] silicon, bis[2‐azepan‐1‐yl)ethoxy] [phthalocyaninato] silicon, and bis[(2,4,6‐tris(N,N‐dimethylamminomethyl) phenoxy)] [phthalocyaninato] silicon and their water‐soluble derivatives.…”

Section: Resultsmentioning

confidence: 99%

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Silicon Phthalocyanines as Anti‐infectious, Antioxidant, and Anticancer Agents

Yenilmez¹,

Farajzadeh²,

Tollu³

et al. 2023

ChemistrySelect

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This study reports the synthesis of three silicon phthalocyanines (SiPc1–3) bearing 2‐dimethylaminoethoxy, 2‐[2‐(dimethylamino)ethoxy]ethoxy, or 2‐{2‐[2‐(dimethylamino)ethoxy]ethoxy}ethoxy on axial positions. Also, their quaternized derivatives (SiPcQ1–3) were prepared. The effect of ligand length on the biological features of water‐soluble silicon phthalocyanines (SiPcQ1–3) was investigated. The highest antimicrobial activity was obtained 32 μg/mL for SiPcQ1 against double‐distilled water, E. hirae, and E. faecalis. The growth inhibition percentages of compounds SiPcQ1–3 were obtained 100 %, 100 %, and 85.14 %, respectively. The highest biofilm inhibition activity was obtained 86.16 % for 250 mg/L SiPcQ3 against S. aureus. The E. coli growth inhibition activities of 50 mg/L compounds SiPcQ1–3 ranged from 60.17 % to 87.53 % and their activities increased (73.46 %–95.37 %) by the enhancement of the concentration. The E. coli viability inhibition activities of SiPcQ1–3 were concentration‐dependent. The DNA cleavage and binding properties of SiPcQ1–3 were studied using pBR322 DNA and CT‐DNA, respectively. Besides, the toxicity of SiPcQ1–3 was examined against the human colon cancer cell line (DLD‐1). The IC50 values of compounds (SiPcQ1–3) were obtained between 10.12 and 27.06 μM in the dark, however, these values were calculated between 12.32 and 22.17 μM under the light. SiPcQ3 exhibited the highest in vitro anticancer activity against the tested cell.

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Section: Resultsmentioning

confidence: 99%

“…Ağırtaş et al synthesized 2,10,16,24-tetrakis (phenoxy 3 methoxy benzoic acid) phthalocyaninato) Co(II) and Cu(II) compounds and the complexes exhibited CT-DNA binding activities. [56] derivatives. The quaternized phthalocyanines displayed good DNA-targeting efficiency.…”

Section: Pharmacology/biology Pbr322 Dna Cleavage Studies Of Compound...mentioning

confidence: 99%

Silicon Phthalocyanines as Anti‐infectious, Antioxidant, and Anticancer Agents

Yenilmez¹,

Farajzadeh²,

Tollu³

et al. 2023

ChemistrySelect

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“…The synthesis and characterization of phenoxy-3-methoxybenzoic compound (3) had been previously reported in the literature [23].…”

Section: The Synthesis Of Phenoxy-3-methoxybenzoic Compound (3)mentioning

confidence: 99%

“…The nickel (II) compound was synthesized with the reaction of the compound (3) in medium of NiCl2, which was previously stated in the literature [23]. The yield was 0.017 g (33 %).…”

Section: The Synthesis Of the Nickle (Ii) Phthalocyanine Compound (Pcni)mentioning

confidence: 99%

The Study of Interaction Activity of Nickel (ll) Phthalocyanine Complex Bearing Tetra Substituted Phenoxy-3-Methoxybenzoic Acid Groups with DNA

Arslantaş

Ağırtaş

2023

Gazi University Journal of Science

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Nickel phthalocyanine complex containing 4-(3,4-dicyanophenoxy)-3-methoxybenzoic acid group was synthesized and specified by way of FT-IR, NMR, UV/Vis procedures. The binding of PcNi complex to CT-DNA was examined via electronic absorption titration, emission titration, melting temperature, viscosity measurement, and agarose gel electrophoresis technics, respectively. The DNA interaction activity of PcNi against CT-DNA was studied by way of UV/Vi titrations, fluorescence spectra, farther by conducting melting point, viscosity procedures in the buffer of a pH 7.02. The obtained outcomes from these methods demonstrated that PcNi indicated substantial binding affinity to the DNA via intercalating by the binding constant of 1.31 x 106 m-1. Further, the interaction activity of the complex on CT-DNA was investigated by which the electrophoresis technique and this procedure indicated that PcNi complex exhibits strong binding affinity on the DNA.

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Novel impedimetric sensing strategy for detecting ochratoxin A based on NH2-MIL-101(Fe) metal-organic framework doped with cobalt phthalocyanine nanoparticles

Song

Zhang

et al. 2021

Food Chemistry

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DNA binding studies of the 2,10,16,24–tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds

Cited by 5 publications

References 41 publications

Silicon Phthalocyanines as Anti‐infectious, Antioxidant, and Anticancer Agents

Silicon Phthalocyanines as Anti‐infectious, Antioxidant, and Anticancer Agents

The Study of Interaction Activity of Nickel (ll) Phthalocyanine Complex Bearing Tetra Substituted Phenoxy-3-Methoxybenzoic Acid Groups with DNA

Novel impedimetric sensing strategy for detecting ochratoxin A based on NH2-MIL-101(Fe) metal-organic framework doped with cobalt phthalocyanine nanoparticles

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