DNA Block Copolymer Micelles – A Combinatorial Tool for Cancer Nanotechnology

Alemdaroglu, Fikri E.; Alemdaroglu, N. Ceren; Langguth, Peter; Herrmann, Andreas

doi:10.1002/adma.200700866

Cited by 195 publications

(191 citation statements)

References 39 publications

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“…Dendrimer's structure and their tunable surface make them ideal to either encapsulate or conjugate the desired drug based on the drug properties. These features introduce dendrimers as properly well-suited delivery vehicles for various anticancer agents (Alemdaroglu et al, 2008;Patil et al, 2009). Therefore, we attempted to study the efficiency of nanoparticles in delivering curcumin and enhancing its anti-proliferative effect on breast cancer cells and to compare the inhibitory effect of PAMAM dendrimers encapsulating curcumin with free curcumin on telomerase activity of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

PAMAM Dendrimers Augment Inhibitory Effects of Curcumin on Cancer Cell Proliferation: Possible Inhibition of Telomerase

Mollazade¹,

Nejati-Koshki²,

Akbarzadeh³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Despite numerous useful anticancer properties of curcumin, its utility is limited due to its hydrophobic structure. In this study, we investigated the comparative antiproliferative effect of PAMAM encapsulating curcumin with naked curcumin on the T47D breast cancer cell line. Materials and Methods: Cytotoxic effects of PAMAM dendrimers encapsulating curcumin and curcumin alone were investigated by MTT assay. After treating cells with different concentrations of both curcumin alone and curcumin encapsulated for 24h, telomerase activity was determined by TRAP assay. Results: While PAMAM dendrimers encapsulating curcumin had no cytotoxicity on cancer cells, they decreased the IC 50 for proliferation and also increased the inhibitory effect on telomerase activity. Conclusions: Considering the non-toxicity in addition to effectiveness for enhancing curcumin anticancer properties, dendrimers could be considered good therapeutic vehicles for this hydrophobic agent.

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Section: Introductionmentioning

confidence: 99%

PAMAM Dendrimers Augment Inhibitory Effects of Curcumin on Cancer Cell Proliferation: Possible Inhibition of Telomerase

Mollazade¹,

Nejati-Koshki²,

Akbarzadeh³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…After investigating the non-directed uptake of DBC aggregates, these systems were employed for targeted chemotherapeutic drug delivery [158]. For that purpose ODN-modified targeting units (folic acid) were "clicked" into the spherical micelle corona by hybridization, allowing perfect control of surface functionalities of the nanoparticle system.…”

Section: Amphiphilic Dna Block Copolymersmentioning

confidence: 99%

Drug delivery systems based on nucleic acid nanostructures

Vries

Zhang

Herrmann

2013

Journal of Controlled Release

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a b s t r a c t a r t i c l e i n f oThe field of DNA nanotechnology has progressed rapidly in recent years and hence a large variety of 1D-, 2D-and 3D DNA nanostructures with various sizes, geometries and shapes is readily accessible. DNA-based nanoobjects are fabricated by straight forward design and self-assembly processes allowing the exact positioning of functional moieties and the integration of other materials. At the same time some of these nanosystems are characterized by a low toxicity profile. As a consequence, the use of these architectures in a biomedical context has been explored. In this review the progress and possibilities of pristine nucleic acid nanostructures and DNA hybrid materials for drug delivery will be discussed. For the latter class of structures, a distinction is made between carriers with an inorganic core composed of gold or silica and amphiphilic DNA block copolymers that exhibit a soft hydrophobic interior.

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“…The similar interest in using other three major types of macromolecules, namely, protein, lipids, carbonhydrates, as structural component for synthetic materials is also increasing (Ball 2005). For reviews in this regard particularly those on DNA based nanomaterials, readers are referred to the latest and comprehensive reviews by Seeman (Seeman 2007), Lu (Lu & Liu 2006, Lu & Liu 2007 and others (Alemdaroglu et al 2008, Ball 2005, Condon 2006, Mrksich 2005, Niemeyer 2000. The focus of this review is the macroscopic materials designed, synthesized, and applied based on or inspired by DNA and the application of these materials specifically for biology and medicine.…”

Section: Introductionmentioning

confidence: 99%

“…These attributes of DNA give rise to many favorable properties of DNA based macromaterials that are having and will have a wide range of applications. In synthesizing and constructing these DNA based structures, DNA has been used to provide template (e.g., (Aldaye et al 2008, Niemeyer 2000), serve as building block (e.g., (Ball 2005)), function as www.intechopen.com versatile linkages in the network (e.g., (Lin et al 2004b, Um et al 2006b)), and aid in the fabrication of the nano-, micro-, and macro-materials (e.g., (Alemdaroglu et al 2008)). This is also of interest to the community of synthetic chemistry .…”

Section: Introductionmentioning

confidence: 99%