DNA breaking activity and mutagenicity of soy sauce: characterization of the active components and identification of

Hiramoto, Kazuyuki; Sekiguchi, Kazuma; Ayuha, K.; Aso-o, Reiko; Moriya, Natsuko; Kato, Tetsuta; Kikugawa, Kiyomi

doi:10.1016/s0165-1161(96)90258-7

Cited by 45 publications

(44 citation statements)

References 30 publications

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“…Authors did not observe any mutagenic activity associated with HMF but certain cytotoxicity was found [Hiramoto et al, 1996].…”

Section: Carcinogenic Toxic and Mutagenic Activities Of Hmfmentioning

confidence: 91%

“…Cytotoxicity (trypan blue exclusion) of HMF was also investigated. The authors designated LC 50 . The results of trypan blue exclusion indicated that HMF had a moderate influence on V79 (LC 50 =115 mmol/L) and Caco-2 (LC 50 =118 mmol/L), they also demonstrated the cytotoxicity, with IC 50 =6.4 mmol/L, which suggests weak cytotoxic activity.…”

Section: Carcinogenic Toxic and Mutagenic Activities Of Hmfmentioning

confidence: 99%

“…HMF has especially been used for this purpose for a long time. On the other hand, HMF present in foodstuffs, seems to be studied extensively not only as a useful index of thermal processing but also as a food contaminant with potential harmful properties [Lee et al, 1995;Hiramoto et al, 1996 …”

Section: Introductionmentioning

confidence: 99%

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5-Hydroxymethyl-2-Furfural (HMF) – Heat-Induced Formation, Occurrence in Food and Biotransformation - a Review

Kowalski¹,

Łukasiewicz²,

Duda-Chodak³

et al. 2013

Pol. J. Food Nutr. Sci.

132

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The chemical structure of 5-hydroxymethyl-2-furfural (HMF), its physicochemical properties and reactions that lead to the synthesis of HMF were discussed. Special attention was paid to HMF formation in food during processing. The potential applications of this compound in industry were described as well. Moreover, this review outlines the most important sources of HMF in human diet and estimates the potential daily intake of HMF by consumers. The known and suggested metabolic pathways, as well as the impact of HMF and its metabolites on human health are also discussed.

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“…Authors did not observe any mutagenic activity associated with HMF but certain cytotoxicity was found [Hiramoto et al, 1996].…”

Section: Carcinogenic Toxic and Mutagenic Activities Of Hmfmentioning

confidence: 91%

Section: Carcinogenic Toxic and Mutagenic Activities Of Hmfmentioning

confidence: 99%

See 1 more Smart Citation

5-Hydroxymethyl-2-Furfural (HMF) – Heat-Induced Formation, Occurrence in Food and Biotransformation - a Review

Kowalski¹,

Łukasiewicz²,

Duda-Chodak³

et al. 2013

Pol. J. Food Nutr. Sci.

132

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“…Reverse mutations were also observed in S. typhimurium TA100, but not TA98 with 4-hydroxy-5-methylfuran-3(2H)-one [FL-no: 13.085] (Hiramoto et al, 1996a) and with 2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone [FL-no: 13.084] (Li et al, 1998). The other strains were not tested.…”

Section: -Hydroxy-5-methylfuran-3(2h)-one [Fl-no: 13085] and 2-ethymentioning

confidence: 99%

“…Potassium iodide, mannitol, sodium azide and ethanol were also inhibitory to the DNA breaking showing involvement of hydroxy radicals. Spin trapping agents and thiol compounds and metal chelators also effectively inhibited the breaking of DNA (Hiramoto et al, 1996a Study results and comments on study validity are presented in Appendix C, Tables 6 and 7.…”

Section: Mechanistic Datamentioning

confidence: 99%

Scientific Opinion on Flavouring Group Evaluation 220 Revision 3 (FGE.220Rev3): Consideration of genotoxic potential for α,β‐unsaturated 3(2H)‐Furanones from subgroup 4.4 of FGE.19

Flavourings¹

2015

EFS2

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The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of 10 flavouring substances from FGE.19 subgroup 4.4, in the Flavouring Group Evaluation 220 (FGE.220). FGE.220 is subdivided into two subgroups: subgroup 4.4a containing [FL‐no: 13.089, 13.117, 13.119, 13.157 and 13.175] and subgroup 4.4b containing [13.010, 13.084 and 13.085, 13.099 and 13.176]. For both subgroups the Panel concluded that the genotoxicity alert could not be ruled out based on the data available and accordingly additional genotoxicity data were requested. In FGE.220, Revision 1, the Panel concluded that for the substances in subgroup 4.4b there is no concern for genotoxicity. In FGE.220, Revision 2, the Panel evaluated genotoxicity studies on two representative substances of subgroup 4.4a: 2,5‐dimethylfuran‐3(2H)‐one [FL‐no:13.119] and 4‐acetyl‐2,5‐dimethylfuran‐3(2H)‐one [FL‐no: 13.175]. Based on the submitted data the Panel concluded that 2,5‐dimethylfuran‐3(2H)‐one [FL‐no: 13.119] does not give rise to concern with respect to genotoxicity. For 4‐acetyl‐2,5‐dimethylfuran‐3(2H)‐one [FL‐no: 13.175] the concern for genotoxicity could not be ruled out, therefore the Panel requested a repetition of the submitted micronucleus study in the presence of S9‐mix, or a combined in vivo micronucleus and Comet assay, including analysis of the liver. The Flavour Industry has tested again 4‐acetyl‐2,5‐dimethylfuran‐3(2H)‐one [FL‐no: 13.175] in an in vitro micronucleus assay as was requested by the Panel. This new study is evaluated in FGE.220, Revision 3, where the Panel concluded that [FL‐no: 13.175] does not give rise to concern with respect to genotoxicity and can be evaluated using the Procedure. This is also applicable to other two substances in subgroup 4.4a: 2,5‐dimethyl‐4‐methoxyfuran‐3(2H)‐one [FL‐no:13.089] and 2,5‐dimethyl4‐ethoxyfuran‐3(2H)‐one [FL‐no:13.117]. Based on the available data the substances of this FGE are no longer of concern with respect to genotoxicity and can be evaluated through the Procedure.

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Biological Activities of Maillard Reaction Products

Marko

2007

Thermal Processing of Food

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DNA breaking activity and mutagenicity of soy sauce: characterization of the active components and identification of

Cited by 45 publications

References 30 publications

5-Hydroxymethyl-2-Furfural (HMF) – Heat-Induced Formation, Occurrence in Food and Biotransformation - a Review

5-Hydroxymethyl-2-Furfural (HMF) – Heat-Induced Formation, Occurrence in Food and Biotransformation - a Review

Scientific Opinion on Flavouring Group Evaluation 220 Revision 3 (FGE.220Rev3): Consideration of genotoxic potential for α,β‐unsaturated 3(2H)‐Furanones from subgroup 4.4 of FGE.19

Biological Activities of Maillard Reaction Products

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