DNA cell cycle distribution and glutathione (GSH) content according to circadian stage in bone marrow of cancer patients

Smaaland, Rune; Jf, Abrahamsen; Svardal, A. M.; Lote, K; Ueland, Per Magne

doi:10.1038/bjc.1992.213

Cited by 38 publications

(25 citation statements)

References 39 publications

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“…Our data suggested that the retinal expression of EPO and its receptor (EPOR), as well as subsequent Janus kinase 2 (Jak2) phosphorylations, are tightly linked to a time window after oxidative stress and in anticipation of daily light onset. This is consistent with physiological protection against daily light-induced, oxidative mediated apoptosis [Hardeland et al, 2003;Hrushesky 1985;Scheving et al, 1988;Smaaland et al, 1991;Smaaland et al, 1992].…”

Section: Neuroprotective Erythropoietin (Epo)supporting

confidence: 57%

New Biomarkers in the Retina and RPE Under Oxidative Stress

Jahng¹

2012

Ocular Diseases

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Section: Neuroprotective Erythropoietin (Epo)supporting

confidence: 57%

New Biomarkers in the Retina and RPE Under Oxidative Stress

Jahng¹

2012

Ocular Diseases

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“…The behavior of DNA replication, the most readily identifiable cell cycle event in this culture system, is dynamically similar to the circadian time-scale gating seen in animal model systems (35) and humans (36) where a correlation between glutathione levels and circadian gating of cells into S phase has been observed (36). The role of reactive oxygen intermediates and the cellular mechanisms preventing damage to single-stranded DNA during replication have been extensively studied (37,38).…”

Section: Temporal Organization Of Functionally Related Transcriptsmentioning

confidence: 95%

A genomewide oscillation in transcription gates DNA replication and cell cycle

Klevecz

Bolen

Forrest

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

298

390

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Microarray analysis from a yeast continuous synchrony culture system shows a genomewide oscillation in transcription. Maximums in transcript levels occur at three nearly equally spaced intervals in this Ϸ40-min cycle of respiration and reduction. Two temporal clusters (4,679 of 5,329) are maximally expressed during the reductive phase of the cycle, whereas a third cluster (650) is maximally expressed during the respiratory phase. Transcription is organized functionally into redox-state superclusters with genes known to be important in respiration or reduction being synthesized in opposite phases of the cycle. The transcriptional cycle gates synchronous bursts in DNA replication in a constant fraction of the population at 40-min intervals. Restriction of DNA synthesis to the reductive phase of the cycle may be an evolutionarily important mechanism for reducing oxidative damage to DNA during replication.

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“…Mean bone-marrow DNA synthesis was higher at 12:00 hr than at midnight in 11 patients with advanced malignancies; interestingly, individual midday peaks were not found in 4 patients with suppressed or inverted cortisol circadian rhythm (Smaaland et al, 1992). In a group of 11 patients with advanced cancer, circadian rhythms in urinary volume and oral temperature were validated (Hrushesky et al, 1982).…”

Section: Healthy Tissuesmentioning

confidence: 98%

Circadian-system alterations during cancer processes: A review

1997

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Murine and human data have indicated that tumors and tumor-bearing hosts may exhibit nearly normal or markedly altered circadian rhythms. Amplitude damping, phase shifts, and/or period (t) change, including appearance of ultradian rhythms (with t F 20 hr) usually become more prominent at late stages of cancer development. The extent of rhythm alterations also varies according to tumor type, growth rate and level of differentiation. While ''group chronotherapy,'' i.e., administration of the same chronomodulated schedule to cancer patients, has increased chemotherapy efficacy and/or tolerability, cancer patients' individual circadian rhythms now need to be explored on a large scale, in order to estimate the incidence of cancer-associated circadian-system alterations and to understand the underlying mechanisms. Correlations between such alterations and patient outcome must be established in order to specify the need for individualized chronomodulated delivery schedules and/or specific rhythmoriented therapy, especially in patients with circadian-system disturbances. Int. J. Cancer, 70:241-247, 1997.r 1997 Wiley-Liss, Inc.Biological functions are modulated by rhythms along several periodic time-scales, i.e., ultradian (with a period, t, shorter than 20 hr), circadian (t approx. 24 hr) or infradian (t . 28 hr). Circadian rhythms are endogenous, genetically based, and coordinated by at least one biological clock, the supra-chiasmatic nucleus (SCN). The circadian periodicity of the SCN can be calibrated by environmental cycles with a t approaching 24 hr. The 24-hr light-dark cycle plays such a role, via specific neuronal pathways and neuromediators, and via darkness-induced secretion of melatonin.

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DNA cell cycle distribution and glutathione (GSH) content according to circadian stage in bone marrow of cancer patients

Abstract: Summary DNA cell cycle distribution and glutathione (GSH) content in bone marrow were measured both at daytime and midnight over single 24

Cited by 38 publications

References 39 publications

New Biomarkers in the Retina and RPE Under Oxidative Stress

New Biomarkers in the Retina and RPE Under Oxidative Stress

A genomewide oscillation in transcription gates DNA replication and cell cycle

Circadian-system alterations during cancer processes: A review

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