Dna Cleavage and Antimicrobial Activity Studies on Transition Metal(ii) Complexes of 4-Aminoantipyrine Derivative

Abstract

A new series of transition metal complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been synthesized from the Schiff base (L) derived from 4-aminoantipyrine, salicylaldehyde and o-phenylenediamine. The structural features have been arrived from their elemental analyses, magnetic susceptibility, molar conductivity, FAB-mass, IR, UV-Vis., 1 H NMR and ESR spectral studies. The data show that the complexes have composition of ML type. The UV-Vis., magnetic susceptibility and ESR spectral data of the complexes suggest a square-planar geometry around the central metal ion. The antimicrobial activities of the metal chelates against the bacteria Salmonella typhi, Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli and fungi Aspergillus niger, Aspergillus flavus and Rhizoctonia bataicola have been carried out. A comparative study of MIC values of the Schiff base and its metal complexes indicates that the metal complexes exhibit higher antibacterial activity than the free ligand. The nuclease activity of the above metal complexes shows only the copper complex cleaves DNA.

Synthesis, Characterization, Antimicrobial and Anticancer Activities of 14-Membered Macrocyclic Schiff Base Metal Complexes

“…[NiL]Cl2 shows three bands at 30960, 22728 and 15601 cm ) and 2 < g⊥ (2.08) < gll (2.37) is coincide well with other related systems and akin to axially symmetric square planar geometry [38]. Table-4.…”

Synthesis and Antibacterial Study of Thymol Derivatives

“…By employing the previous published method [11], thymol ethers (2,3) have been synthesized by the reaction of thymol (1) with benzyl halide in the presence of K 2 CO 3 . Whilst, the treatment of thymol (1) (2)(3)(4)(5)(6) All the derivatives (2-6) were screened for their antibacterial activity [11][12][13]. Unfortunately, when compared with standard drug as streptomycin, all the derivatives (2-6) do not show any antibacterial activity against all four types of bacteria.…”

Synthesis, Spectral Characterization and Antibacterial Investigation of Ni(II) Coordination Complexes of Macrocyclic Schiff base ligands Derived from 4-Aminoantipyrine

“…Much work have been reported from many fields on 4-aminoantipyrine,which act as precursor to prepare a large number of various transition metal complexes [9][10][11] . Specifically Schiff bases derived from 4-aminoantipyrine and their complexes are most concerned because of their utility in the field of biology [12][13][14][15][16][17] .…”