DNA conformational equilibrium enables continuous changing of curvatures

Mao, Dake; Paluzzi, Victoria E.; Zhang, Cuizheng; Mao, Chengde

doi:10.1039/d2nr05404c

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…This study is based on a recently reported, engineered DNA crystal system with a basic structural motif of a double crossover-like motif (DXL), as shown in Figure 1 and Figure S1 (Supporting Information). [27,28] The DXL motif contains two 16-nucleotide (nt)-long DNA single strands, either identical or different. The two strands hybridize into two, interconnected, 6-base pair (bp)-or half-turn-long DNA duplexes.…”

Section: Introductionmentioning

confidence: 99%

Implementing Logic Gates by DNA Crystal Engineering

et al. 2023

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DNA self‐assembly computation is attractive for its potential to perform massively parallel information processing at the molecular level while at the same time maintaining its natural biocompatibility. It has been extensively studied at the individual molecule level, but not as much as ensembles in 3D. Here, the feasibility of implementing logic gates, the basic computation operations, in large ensembles: macroscopic, engineered 3D DNA crystals is demonstrated. The building blocks are the recently developed DNA double crossover‐like (DXL) motifs. They can associate with each other via sticky‐end cohesion. Common logic gates are realized by encoding the inputs within the sticky ends of the motifs. The outputs are demonstrated through the formation of macroscopic crystals that can be easily observed. This study points to a new direction of construction of complex 3D crystal architectures and DNA‐based biosensors with easy readouts.

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Section: Introductionmentioning

confidence: 99%