DNA Core@Inorganic Shell

Abstract

A chemically well-defined Bio Core@Inorganic Shell nanohybrid, which consists of rationally designed DNA molecule core with a size of ∼100 nm and spherical inorganic nanoshell with an overall thickness of ∼10 nm reassembled with exfoliated layered metal hydroxide (MH nanosheets), is prepared. The DNA encapsulation and its release, due to the pH-dependent solubility of the MH nanoshell, plays a crucial role in maximizing the stability of base sequence-manipulated and probe-functionalized DNA molecules with designed information. The present DNA Core@MH Shell nanohybrid can provide wide bioinspired applications converged with nanotechnology, such as an advanced gene delivery system and a biomedical diagnostics, tracing/collection/sensing system for DNA-based information.

Surface modification of acetaminophen particles by atomic layer deposition

“…Novel drug delivery systems (Terracciano et al, 2015) are needed for the stabilization of acetaminophen nanocrystals in aqueous medium (Das et al, 2013), targeted drug delivery based on metal cation attachment to active pharmaceutical ligand forming coordination compounds (Ledeti et al, 2013), and biomedical imaging and molecular diagnostics (Park et al, 2010).…”

Selective DNA Adsorption on Layered Double Hydroxide Nanoparticles

“…As shown in Figure 1(c), the FT-IR spectrum exhibits all the characteristic stretching vibrations of LDHs. Peaks at 3400 and 800 cm −1 are attributed to the ν(OH) and ν(M-O) in the metal hydroxide layers whereas those at 1630 and 1370 cm −1 are explained by the δ(OH) and ν 3 (CO 3 2− ) modes of interlayer water molecules and carbonate ions, respectively.…”

“…[1][2][3][4][5] In biotechnologies, DNA is selectively separated from cells or tissues in order to verify the genetic disorder or to modify the genetic information.…”

“…3,5 Numerous inorganic adsorption systems including silica, metal oxide, and hydroxide are extensively studied and some of them are already commercialized. 6 Among those inorganic adsorbents, layered double hydroxide (LDH) nanoparticles, which are also called anionic nanoclay, 7,8 are considered as potent DNA collection material as they have tunable physicochemical properties like surface area, particle size, and charge density as well as biocompatibility.…”

Bioinspired Synthesis of Organic/Inorganic Nanocomposite Materials Mediated by Biomolecules

“…Due to the pH-dependent solubility of the MH nanoshell, the DNA can be encapsulated and released, which play a crucial role in maximizing the stability of base sequence-manipulated and probe-functionalized DNA molecules with designed information. Therefore, these hybrid materials could be used as advanced gene delivery systems and a biomedical diagnostics system for DNA-based information (Park et al 2010). A multi-lamellar structure was formed by complexes of anionic DNA and cationic liposomes self-assembly.…”