2021
DOI: 10.1016/j.csbj.2021.11.033
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DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans

Abstract: Cells are constantly challenged by internal or external genotoxic assaults, which may induce a high frequency of DNA lesions, leading to genome instability. Accumulation of damaged DNA is severe or even lethal to cells and can result in abnormal proliferation that can cause cancer in multicellular organisms, aging or cell death. Eukaryotic cells have evolved a comprehensive defence system termed the DNA damage response (DDR) to monitor and remove lesions in their DNA. The DDR has been extensively studied in th… Show more

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Cited by 18 publications
(18 citation statements)
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References 118 publications
(153 reference statements)
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“…As well, histone acetyltransferase RTT109 was upregulated; its ortholog in S. cerevisiae functions in the NHEJ pathway through interaction with ScVps75 [ 35 ]. DNA helicases have major roles in genome maintenance by unwinding structured nucleic acids and thus are involved in HR, NER, and PPR pathways [ 4 , 36 ]. Here, a putative 3’-5’ DNA helicase MPH1 was induced with MMS treatment in C. albicans .…”
Section: Resultsmentioning
confidence: 99%
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“…As well, histone acetyltransferase RTT109 was upregulated; its ortholog in S. cerevisiae functions in the NHEJ pathway through interaction with ScVps75 [ 35 ]. DNA helicases have major roles in genome maintenance by unwinding structured nucleic acids and thus are involved in HR, NER, and PPR pathways [ 4 , 36 ]. Here, a putative 3’-5’ DNA helicase MPH1 was induced with MMS treatment in C. albicans .…”
Section: Resultsmentioning
confidence: 99%
“…However, several intrinsic and extrinsic factors, including cell metabolism, replication stress, radiation, and viral infection, may stress genomic DNA, introducing a variety of DNA lesions [ 2 , 3 ]. In particular, reactive oxygen species (ROS) and other active molecules generated by host immune cells cause oxidative DNA damage stress on pathogenic microorganisms [ 4 , 5 ]. To defend against such damage-inducing events, DNA damage response (DDR) pathways are employed for cells to sense and fix damaged DNA, allowing successful colonization in hosts [ 6 , 7 , 8 ].…”
Section: Introductionmentioning
confidence: 99%
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