DNA damage evaluated by alkaline single cell gel electrophoresis (SCGE) in children of Chernobyl, 10 years after the disaster

Frenzilli, Giada; Bosco, Elena; Antonelli, Alessandro; Panasiuk, G.; Barale, Roberto

doi:10.1016/s1383-5718(01)00136-x

Cited by 15 publications

(4 citation statements)

References 25 publications

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“…In addition, ionizing radiation also causes a variety of cellular responses. Chronic low-level irradiation from different isotopes or to a low dose of X-rays is known to induce the adaptive response (Sasaki, 1996;Konopacka et al, 1998;Ghiassi-Nejad et al, 2002) and clastogenic factor (Frenzilli et al, 1998(Frenzilli et al, , 2001. Irradiation with 0.05e0.1 Gy of Xrays diminishes the bone marrow death after mid-lethal irradiation in ICR male mice two months after the priming irradiation (Yonezawa et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

High background radiation areas of Ramsar in Iran: evaluation of DNA damage by alkaline single cell gel electrophoresis (SCGE)

Masoomi

Mohammadi²,

Amini

et al. 2006

Journal of Environmental Radioactivity

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Section: Introductionmentioning

confidence: 99%

High background radiation areas of Ramsar in Iran: evaluation of DNA damage by alkaline single cell gel electrophoresis (SCGE)

Masoomi

Mohammadi²,

Amini

et al. 2006

Journal of Environmental Radioactivity

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“…Frenzilli, Bosco, Antonelli, Panasiuk, and Barale (2001) reported a significantly higher level of DNA damage in healthy children from Belarus 10 years after exposure to the Chernobyl accident compared to a control group of healthy children from Pisa, Italy. They used an alkaline single-cell gel electrophoresis comet assay that proved reliable in demonstrating DNA damage as a function of low levels of chronic environmental radio contamination.…”

Section: Radiation and Dna Damagementioning

confidence: 87%

Low-dose environmental radiation, DNA damage, and cancer: The possible contribution of psychological factors

Cwikel

Gidron

Quastel

2010

Psychology, Health & Medicine

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Radiation causes DNA damage, increases risk of cancer, and is associated with psychological stress responses. This article proposes an evidence-based integrative model in which psychological factors could interact with radiation by either augmenting or moderating the adverse effects of radiation on DNA integrity and eventual tumorigenesis. Based on a review of the literature, we demonstrate the following: (1) the effects of low-dose radiation exposures on DNA integrity and on tumorigenesis; (2) the effects of low-dose radiation exposure on psychological distress; (3) the relationship between psychological factors and DNA damage; and (4) the possibility that psychological stress augments and that psychological resource variables moderate radiation-induced DNA damage and risk of cancer. The additional contribution of psychological processes to radiation-DNA damage-cancer relationships needs further study, and if verified, has clinical implications.

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“…Increased rates of DNA damage and mutation rates have been reported from Chernobyl [23] , [37] – [45] . Admittedly, the literature reports heterogeneous results on DNA damage and mutation rate in organisms living in areas around Chernobyl with low levels of contamination [46] – [49] .…”

Section: Introductionmentioning

confidence: 99%

Aspermy, Sperm Quality and Radiation in Chernobyl Birds

et al. 2014

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BackgroundFollowing the Chernobyl nuclear power plant accident, large amounts of radionuclides were emitted and spread in the environment. Animals living in such contaminated areas are predicted to suffer fitness costs including reductions in the quality and quantity of gametes.Methodology/Principal FindingsWe studied whether aspermy and sperm quality were affected by radioactive contamination by examining ejaculates from wild caught birds breeding in areas varying in background radiation level by more than three orders of magnitude around Chernobyl, Ukraine. The frequency of males with aspermy increased logarithmically with radiation level. While 18.4% of males from contaminated areas had no sperm that was only the case for 3.0% of males from uncontaminated control areas. Furthermore, there were negative relationships between sperm quality as reflected by reduced sperm velocity and motility, respectively, and radiation.Conclusions/SignificanceOur results suggest that radioactive contamination around Chernobyl affects sperm production and quality. We are the first to report an interspecific difference in sperm quality in relation to radioactive contamination.

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DNA damage evaluated by alkaline single cell gel electrophoresis (SCGE) in children of Chernobyl, 10 years after the disaster

Cited by 15 publications

References 25 publications

High background radiation areas of Ramsar in Iran: evaluation of DNA damage by alkaline single cell gel electrophoresis (SCGE)

High background radiation areas of Ramsar in Iran: evaluation of DNA damage by alkaline single cell gel electrophoresis (SCGE)

Low-dose environmental radiation, DNA damage, and cancer: The possible contribution of psychological factors

Aspermy, Sperm Quality and Radiation in Chernobyl Birds

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