DNA damage in Mexican children living in high-risk contaminated scenarios

Jasso-Pineda, Yolanda; Dı́az-Barriga, Fernando; Yáñez-Estrada, Leticia; Pérez‐Vázquez, Francisco Javier; Pérez-Maldonado, Iván N.

doi:10.1016/j.scitotenv.2015.02.073

Cited by 50 publications

(29 citation statements)

References 78 publications

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“…Data obtained in this investigation showed that the highest mean urinary 1‐OHP level was detected in women who use wood as their principal indoor fuel source for cooking and heating (0.55 ± 0.52 μmol/mol creatinine) (Table ). In line with our results, high urinary 1‐OHP levels have been detected in people chronically exposed to biomass smoke in different studies performed in Mexico (Martínez‐Salinas et al, ; Riojas‐Rodriguez et al, ; Martínez‐salinas et al, ; Pruneda‐Álvarez et al, ; Trejo‐Acevedo et al, , ; Jasso‐Pineda et al, ; Ruiz‐Vera et al, ). Besides, it has been demonstrated that urinary 1‐OHP levels in populations that use biomass combustion as an indoor fuel source is generally higher than those urinary 1‐OHP concentrations found in populations exposed to PAHs through other exposure sources such as vehicular traffic, occupational settings, industrial areas, among others (Chetiyanukornkul et al, ; Polanska et al, ; Yuan et al, ).…”

Section: Discussionsupporting

confidence: 91%

“…Data obtained in this investigation showed that the highest mean urinary 1-OHP level was detected in women who use wood as their principal indoor fuel source for cooking and heating (0.55 AE 0.52 μmol/mol creatinine) (Table II). In line with our results, high urinary 1-OHP levels have been detected in people chronically exposed to biomass smoke in different studies performed in Mexico (Martínez-Salinas et al, 2010;Riojas-Rodriguez et al, 2011;Martínez-salinas et al, 2012;Pruneda-Alvarez et al, 2012;Trejo-Acevedo et al, 2012Jasso-Pineda et al, 2015;Ruiz-Vera et al, 2015b).…”

Section: Urinary1-ohp Concentrationssupporting

confidence: 92%

“…Exposure to PAHs has been associated with several adverse human health effects (Mumtaz and George, ; Kim et al, ), like some cancer types (lung, skin, bladder and gastrointestinal) (Bach et al, ; Olsson et al, ; Diggs et al, ) as well as gastrointestinal, pulmonary, dermatologic, and renal afflictions (Mumtaz and George, ). Also, PAHs are able to induce DNA damage in exposed humans (Torres‐Dosal et al, ; Jasso‐Pineda et al, ; Ledda et al, ). Of interest for the present study is the fact that recent research suggests exposure to PAHs could be an additional risk factor for impaired vascular health and atherogenic processes, which are events that gradually lead to cardiovascular diseases (CVD) (Brucker et al, ; Xu et al, ; Brucker et al, ; Feng et al, ; Deng et al, ; Ruiz‐Vera et al, ; Pruneda‐Alvarez et al, ; Ochoa‐Martinez et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Expression levels of circulating microRNAs‐126, ‐155, and ‐145 in Mexican women exposed to polycyclic aromatic hydrocarbons through biomass fuel use

Ruíz-Vera

Ochoa-Martínez

Pruneda-Álvarez

et al. 2019

Environ and Mol Mutagen

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Human exposure to polycyclic aromatic hydrocarbons (PAHs) has been considered a risk determinant for the development of cardiovascular diseases (CVD). Therefore, the aim of this study was to assess expression levels of vascular‐related miRNAs, miR‐126, miR‐155, and miR‐145, in plasma from women (aged 19–81 years) exposed (n = 100) and non‐exposed (n = 20) to PAHs via biomass combustion smoke.1‐hydroxypyrene (1‐OHP) was determined in urine as a biomarker of exposure to PAHs using high‐resolution liquid chromatography. Plasma expression levels of proposed miRNAs were determined by quantitative real‐time PCR. Additionally, traditional risk factors (age, blood pressure, serum lipid profile, blood glucose, and among others) associated with CVD were evaluated. Urinary 1‐OHP concentrations and plasma expression levels of miR‐126 and miR‐155 were significantly higher (P < 0.05) in women using wood as a fuel source in their homes (indoor) compared to women from the reference group (non‐exposed to biomass smoke). Besides, multivariate linear regression analyses revealed that miR‐126[β = 0.61; 95% confidence interval (0.32–0.90)] and miR‐155 [β = 0.45; 95% confidence interval (0.13–0.84)] expression levels were significantly associated with urinary 1‐OHP concentrations after being adjusted by traditional risk factors (P < 0.05). In contrast, no significant relationship was found between miR‐145 and urinary 1‐OHP levels. Furthermore, miRNAs assessed in this investigation are associated with CVD events. Consequently, actions to reduce exposure to PAHs in the evaluated population are warranted. Environ. Mol. Mutagen. 60:546–558, 2019. © 2019 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 91%

Section: Urinary1-ohp Concentrationssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Expression levels of circulating microRNAs‐126, ‐155, and ‐145 in Mexican women exposed to polycyclic aromatic hydrocarbons through biomass fuel use

Ruíz-Vera

Ochoa-Martínez

Pruneda-Álvarez

et al. 2019

Environ and Mol Mutagen

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“…There are many risks associated with arsenic exposure including genotoxicity and neurotoxicity [Rocha‐Amador et al, ; Tyler and Allan, ; Jasso‐Pineda et al, ]. Exposure to this metalloid also represents a risk for metabolic disorders [Osorio‐Yáñez et al, and ; Mendez et al, ], respiratory damage [Olivas‐Calderón et al, ; Recio‐Vega et al, ] and diabetes [Del Razo et al, ; Drobná et al, ] at exposure levels comparable to those used in the present study.…”

Section: Introductionmentioning

confidence: 99%

DNA methylation changes in Mexican children exposed to arsenic from two historic mining areas in San Luis potosí

Alegría-Torres

Carrizales-Yáñez

Dı́az-Barriga

et al. 2016

Environ and Mol Mutagen

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Arsenic is a carcinogen and epimutagen that threatens the health of exposed populations worldwide. In this study, we examined the methylation status of Alu and long interspersed nucleotide elements (LINE-1) and their association with levels of urinary arsenic in 84 Mexican children between 6 and 12 years old from two historic mining areas in the State of San Luis Potosí, Mexico. Urinary arsenic levels were determined by atomic absorption spectrophotometry and DNA methylation analysis was performed in peripheral blood leukocytes by bisulfite-pyrosequencing. The geometric mean of urinary arsenic was 26.44 µg/g Cr (range 1.93-139.35). No significant differences in urinary arsenic or methylation patterns due to gender were observed. A positive correlation was found between urinary arsenic and the mean percentage of methylated cytosines in Alu sequences (Spearman correlation coefficient r = 0.532, P < 0.001), and a trend of LINE-1 hypomethylation was also observed (Spearman correlation coefficient r = -0.232, P = 0.038) after adjustment for sex and age. A linear regression model showed an association with log-normalized urinary arsenic for Alu (β = 1.05, 95% CI: 0.67; 1.43, P < 0.001) and LINE-1 (β = -0.703, 95% CI: -1.36; -0.38, P = 0.038). Despite the low-level arsenic exposure, a subtle epigenetic imbalance measured as DNA methylation was detected in the leukocytes of Mexican children living in two historic mining areas. Environ. Mol. Mutagen. 57:717-723, 2016. © 2016 Wiley Periodicals, Inc.

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“…Así mismo, se observó una posible relación entre 3,5,6-tricloro-2-piridinol (un biomarcador de exposición de clorpirifos y clorpirifos-metil) con el trastorno de déficit de atención, en niños de la ciudad de México (Fortenberry et al 2014). La exposición a mezclas de contaminantes (DDT y PAHs) producen mayores daños al ADN en niños expuestos, comparado con exposición a un solo contaminante (Jasso- Pineda et al 2015). En este sentido, niños ocupacionalmente expuestos a OF y CA en plantaciones de tabaco de Nayarit, presentaron una disminución de la actividad AChE entre 15 y hasta 19 % (Gamlin et al 2006).…”

Section: Exposición En Niñosunclassified

Estado Actual De La Investigación Sobre Plaguicidas en México

Hernández

Leyva-Morales

Rodríguez

et al. 2018

Rev. Int. Contam. Ambie.

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Palabras Clave: patrón de uso, exposición laboral, ecosistemas, contaminación, agricultura RESUMENEl presente trabajo analiza la investigación que se ha llevado a cabo en México con relación al uso y efecto de los plaguicidas en el ambiente y salud humana. Se revisaron 394 artículos publicados en los últimos 20 años en revistas indizadas o arbitradas. Las publicaciones se agruparon en 7 temas principales: 1) patrón de uso de plaguicidas, 2) efectos en el ambiente; 3) estudios ecotoxicológicos; 4) exposición en población humana; 5) residuos en alimentos; 6) toxicología de plaguicidas (estudios in vitro e in vivo); y 7) bioplaguicidas y biorremediación. El análisis de estas investigaciones indican que actualmente se utilizan Plaguicidas Altamente Peligrosos (PAPs) en las zonas agrícolas del país, su uso histórico y actual se relaciona con efectos negativos en ecosistemas terrestres y costeros, se han reportado efectos en la salud de los trabajadores agrícolas y sus familias, tales como alteraciones hematológicas, hormonales, daños genéticos, alteraciones del comportamiento y daños celulares; los niños constituyen el grupo más vulnerable a la exposición, además se han documentado daños genéticos, reproductivos y neuronales en modelos celulares y en organismos de laboratorio y se reportan residuos en alimentos como leche, hortalizas y granos. Como medidas de mitigación, se documentan procesos de biorremediación de suelos y agua contaminada,

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DNA damage in Mexican children living in high-risk contaminated scenarios

Cited by 50 publications

References 78 publications

Expression levels of circulating microRNAs‐126, ‐155, and ‐145 in Mexican women exposed to polycyclic aromatic hydrocarbons through biomass fuel use

Expression levels of circulating microRNAs‐126, ‐155, and ‐145 in Mexican women exposed to polycyclic aromatic hydrocarbons through biomass fuel use

DNA methylation changes in Mexican children exposed to arsenic from two historic mining areas in San Luis potosí

Estado Actual De La Investigación Sobre Plaguicidas en México

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