DNA Damage Responses, the Trump Card of Stem Cells in the Survival Game

Tayanloo-Beik, Akram; Hamidpour, Shayesteh Kokabi; Nikkhah, Amirabbas; Arjmand, Rasta; Mafi, Ahmad Rezazadeh; Rezaei-Tavirani, Mostafa; Larijani, Bagher; Gilany, Kambiz; Arjmand, Babak

doi:10.1007/5584_2023_791

Cited by 1 publication

(2 citation statements)

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“…Not only are the CSC-derived exosomes accountable for tumor progression and tumorigenesis, but they are also amenable to triggering tumor metastasis. This phenomenon has been closely studied in several cases [ 75 – 78 ]. Even so, the precise mechanisms have not yet been described.…”

Section: Extracellular Vesicles and Cancer Stem Cells: Emerging Playe...mentioning

confidence: 99%

“…The TME is defined as the complex of the extracellular matrix (ECM), recruited cells, and chemical factors that aid in harboring, preserving, and stimulating malignant cells [ 162 ]. Several studies have also demonstrated that the survival and renewal of CSCs heavily depend on the existence and maintenance of CSC niches [ 75 , 163 , 164 ]. These micro-environments are composed of the ECM, stromal and immune cells, chemicals (including growth factors and cytokines), and EVs.…”

Section: Extracellular Vesicles and Cancer Stem Cells In The Tumor Mi...mentioning

confidence: 99%

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Extracellular vesicles and cancer stem cells: a deadly duo in tumor progression

Tayanloo-Beik,

Eslami,

Sarvari

et al. 2024

Oncol.Rev.

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The global incidence of cancer is increasing, with estimates suggesting that there will be 26 million new cases and 17 million deaths per year by 2030. Cancer stem cells (CSCs) and extracellular vesicles (EVs) are key to the resistance and advancement of cancer. They play a crucial role in tumor dynamics and resistance to therapy. CSCs, initially discovered in acute myeloid leukemia, are well-known for their involvement in tumor initiation, progression, and relapse, mostly because of their distinct characteristics, such as resistance to drugs and the ability to self-renew. EVs, which include exosomes, microvesicles, and apoptotic bodies, play a vital role in facilitating communication between cells within the tumor microenvironment (TME). They have a significant impact on cellular behaviors and contribute to genetic and epigenetic changes. This paper analyzes the mutually beneficial association between CSCs and EVs, emphasizing their role in promoting tumor spread and developing resistance mechanisms. This review aims to investigate the interaction between these entities in order to discover new approaches for attacking the complex machinery of cancer cells. It highlights the significance of CSCs and EVs as crucial targets in the advancement of novel cancer treatments, which helps stimulate additional research, promote progress in ideas for cancer treatment, and provide renewed optimism in the effort to reduce the burden of cancer.

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Section: Extracellular Vesicles and Cancer Stem Cells: Emerging Playe...mentioning

confidence: 99%