DNA Detection Using Origami Paper Analytical Devices

Scida, Karen; Li, Bingling; Ellington, Andrew D.; Crooks, Richard M.

doi:10.1021/ac402118a

Cited by 116 publications

(66 citation statements)

References 53 publications

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“…26,31,38,40–42,60,61 Crooks et al recently reported an improved fabrication technique utilizing origami folding to eliminate the requirement of using tape to secure layers in a paper-based diagnostic chip and the design of origami paper analytical devices (oPADs) for other applications. 26,60,62–64 Our group has developed a folding analytical device based on treated hydrophobic and embossed paper that can be used to perform sequential incubation and washing steps. 38 In these examples, folding is performed on a planar sheet of paper without the aid of mechanical supports to ensure good alignment between folded layers.…”

Section: Resultsmentioning

confidence: 99%

A Paper-Based “Pop-up” Electrochemical Device for Analysis of Beta-Hydroxybutyrate

et al. 2016

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This paper describes the design and fabrication of a “pop-up” electrochemical paper-based analytical device (pop-up-EPAD) to measure beta-hydroxybutyrate (BHB)—a key biomarker for diabetic ketoacidosis—using a commercial glucometer. Pop-up-EPADs are inspired by pop-up greeting cards and children’s books. They are made from a single sheet of paper folded into a three-dimensional (3D) device that changes shape, and fluidic and electrical connectivity, by simply folding and unfolding the structure. The reconfigurable 3D structure makes it possible to change the fluidic path and to control timing; it also provides mechanical support for the folded and unfolded structures that enables good registration and repeatability on folding. A pop-up-EPAD designed to detect BHB shows performance comparable to commercially available plastic test strips over the clinically relevant range of BHB in blood when used with a commercial glucometer that integrates the ability to measure glucose and BHB (combination BHB/glucometer). With simple modifications of the electrode and fluid path design, the pop-up-EPAD also detects BHB using a simple glucometer—a device that is much more available than combination BHB/glucometers. Strategies that use a “3D pop-up”—that is, large-scale changes a 3D structure and fluidic paths—by folding/unfolding add functionality (e.g., controlled timing, fluidic handling and path programming, control over complex sequences of steps, and alterations in electrical connectivity) to EPADs, and should enable the development of new classes of paper-based diagnostic devices.

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Section: Resultsmentioning

confidence: 99%

A Paper-Based “Pop-up” Electrochemical Device for Analysis of Beta-Hydroxybutyrate

et al. 2016

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“…Paper-based biosensors are a promising bio-detection tools because of the advantageous characteristics of paper substrates, such as flexibility, lightness, biocompatibility and low cost [33]. A Paper-based Electrochemical Immunosensor was developed for label-free detection of foodborne pathogens using an antibody-single walled carbon nanotubes bio-conjugate modified electrode [34].…”

Section: Electrochemical Immunosensor For Detection Of Bacteriamentioning

confidence: 99%

Ultrasensitive Bioaffinity Electrochemical Sensors: Advances and New Perspectives

Alizadeh

Salimi

2018

Electroanalysis

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This article reviews recent advances and developments in the field of bioaffinity electrochemical sensors with emphasis on a subclass including immunosensors, aptasensors, genosensors and molecularly imprinted sensosr. Recent insights into novel fabrication methodologies and electrochemical techniques have resulted in the demonstration of biosensors able to detection of wide range of target analyte. It has been shown that due to their high specificity and sensitivity, they represent a great tool in practical applications. Furthermore, at last couple decades nanotechnology has become very popular in the sensor fields due to the high capacity of nanomaterials to immobilize of bioaffinity agents and also their inhibiting effects on denaturation of enzymes and other bioaffinity systems, which they could well have beneficial effects for the performance of these sensors. The main focus of this review is to discuss methods for immobilizing bioreceptors onto a solid support, introduction of nanomaterials for improve sensitivity of biosensor and various electrochemical sensing platforms. The use of biosensor in these applications is most appropriate, because the analysis of trace substances in medical and healthcare applications, environmental science, and food industries is so important. In addition, recent advances in nanomaterial‐mediated bioaffinity sensors used for onset biosensing, point‐of‐care testing and healthcare management are also highlighted.

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“…Paper has emerged as a promising substrate for implantable devices and wearable electronics because of its universal availability, low cost, environmental friendliness, and ease of fabrication [15][16][17] . Several paper-based platforms have been developed recently, such as lateral flow immunoassays for the detection of analytes 18,19 , detection of DNA or proteins 20 , and electrochemical biosensing 21,22 . Recently, nanofibrous polymeric substrates have been developed to fabricate elastic and flexible electronics that can be sutured 3 .…”

Section: Introductionmentioning

confidence: 99%

A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics

et al. 2016

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Threads, traditionally used in the apparel industry, have recently emerged as a promising material for the creation of tissue constructs and biomedical implants for organ replacement and repair. The wicking property and flexibility of threads also make them promising candidates for the creation of three-dimensional (3D) microfluidic circuits. In this paper, we report on thread-based microfluidic networks that interface intimately with biological tissues in three dimensions. We have also developed a suite of physical and chemical sensors integrated with microfluidic networks to monitor physiochemical tissue properties, all made from thread, for direct integration with tissues toward the realization of a thread-based diagnostic device (TDD) platform. The physical and chemical sensors are fabricated from nanomaterial-infused conductive threads and are connected to electronic circuitry using thread-based flexible interconnects for readout, signal conditioning, and wireless transmission. To demonstrate the suite of integrated sensors, we utilized TDD platforms to measure strain, as well as gastric and subcutaneous pH in vitro and in vivo.

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DNA Detection Using Origami Paper Analytical Devices

Cited by 116 publications

References 53 publications

A Paper-Based “Pop-up” Electrochemical Device for Analysis of Beta-Hydroxybutyrate

A Paper-Based “Pop-up” Electrochemical Device for Analysis of Beta-Hydroxybutyrate

Ultrasensitive Bioaffinity Electrochemical Sensors: Advances and New Perspectives

A toolkit of thread-based microfluidics, sensors, and electronics for 3D tissue embedding for medical diagnostics

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