DNA Double-strand Breaks Induced byFractionated Neutron Beam Irradiation for Boron Neutron Capture Therapy

doi:10.21873/anticanres.11499

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…This could point toward distinctive roles for both parameters, neutrons being responsible for DSBs and gamma ray responsible for ROS production 74 . This observation is in line with previous observation where a fast-neutron beam was also found to be more effective quantitatively than gamma rays in producing DNA DSBs 75,76 . However, to confirm those data, more experiments are needed and will require artificial experimentation to increase the flux of neutrons.…”

Section: Discussionsupporting

confidence: 93%

Cryopreserved Stem Cells Incur Damages Due To Terrestrial Cosmic Rays Impairing Their Integrity Upon Long-Term Storage

et al. 2022

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Stem cells have the capacity to ensure the renewal of tissues and organs. They could be used in the future for a wide range of therapeutic purposes and are preserved at liquid nitrogen temperature to prevent any chemical or biological activity up to several decades before their use. We show that the cryogenized cells accumulate damages coming from natural radiations, potentially inducing DNA double-strand breaks (DSBs). Such DNA damage in stem cells could lead to either mortality of the cells upon thawing or a mutation diminishing the therapeutic potential of the treatment. Many studies show how stem cells react to different levels of radiation; the effect of terrestrial cosmic rays being key, it is thus also important to investigate the effect of the natural radiation on the cryopreserved stem cell behavior over time. Our study showed that the cryostored stem cells totally shielded from cosmic rays had less DSBs upon long-term storage. This could have important implications on the long-term cryostorage strategy and quality control of different cell banks.

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Section: Discussionsupporting

confidence: 93%

Cryopreserved Stem Cells Incur Damages Due To Terrestrial Cosmic Rays Impairing Their Integrity Upon Long-Term Storage

et al. 2022

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“…Radiation damages cancer cells through direct ionization of DNA [15] and other cellular targets via indirect effects [16,17] and the production of hydroxyl free radicals/reactive oxygen species (ROS) that induce DNA damage/strand breaks [18]. IR causes both single-strand breaks (SSBs) [2,19] and double-strand DNA breaks (DSBs) [4,[20][21][22][23] highly occurring in proliferating tumor cells, and the resulting DNA damage often leads to cell death via apoptosis or necrosis (Figures 2 and 3). There are several types of EBRT, including intensity-modulated RT (IMRT), volumetric-modulated arc therapy (VMAT), image-guided radiotherapy (IGRT), 4-dimensional radiotherapy, stereotactic radiotherapy, whole body irradiation and proton beam therapy [24].…”

Section: External Beam Radiation Therapymentioning

confidence: 99%

Innate Immune System in the Context of Radiation Therapy for Cancer

Boopathi

Den

Thangavel

2023

Cancers

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Radiation therapy (RT) remains an integral component of modern oncology care, with most cancer patients receiving radiation as a part of their treatment plan. The main goal of ionizing RT is to control the local tumor burden by inducing DNA damage and apoptosis within the tumor cells. The advancement in RT, including intensity-modulated RT (IMRT), stereotactic body RT (SBRT), image-guided RT, and proton therapy, have increased the efficacy of RT, equipping clinicians with techniques to ensure precise and safe administration of radiation doses to tumor cells. In this review, we present the technological advancement in various types of RT methods and highlight their clinical utility and associated limitations. This review provides insights into how RT modulates innate immune signaling and the key players involved in modulating innate immune responses, which have not been well documented earlier. Apoptosis of cancer cells following RT triggers immune systems that contribute to the eradication of tumors through innate and adoptive immunity. The innate immune system consists of various cell types, including macrophages, dendritic cells, and natural killer cells, which serve as key mediators of innate immunity in response to RT. This review will concentrate on the significance of the innate myeloid and lymphoid lineages in anti-tumorigenic processes triggered by RT. Furthermore, we will explore essential strategies to enhance RT efficacy. This review can serve as a platform for researchers to comprehend the clinical application and limitations of various RT methods and provides insights into how RT modulates innate immune signaling.

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“…Another type of beam used are neutron beams, high LET (linear energy transfer) beams that can cause more DNA damage than photons. 35 Boron neutron capture therapy (BNCT) utilizes boron-10 target drug that accumulates preferentially into the tumors and post neutron irradiation yields lithium-7 and an alpha particle, killing cancer cells specifically and sparing the normal tissue. BNCT has been clinically used in glioblastoma multiforme, meningioma, head and neck cancers, lung cancer, breast cancers, hepatocellular carcinoma, and pediatric cancers etc.…”

Section: Particle Therapymentioning

confidence: 99%

Technological Advancements in External Beam Radiation Therapy (EBRT): An Indispensable Tool for Cancer Treatment

Koka¹,

Verma²,

Dwarakanath³

et al. 2022

CMAR

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Recent technological advancements have increased the efficacy of radiotherapy, leading to effective management of cancer patients with enhanced patient survival and improved quality of life. Several important developments like multileaf collimator, integration of imaging techniques like positron emission tomography (PET) and computed tomography (CT), involvement of advanced dose calculation algorithms, and delivery techniques have increased tumor dose distribution and decreased normal tissue toxicity. Three-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), stereotactic radiotherapy, imageguided radiotherapy (IGT), and particle therapy have facilitated the planning procedures, accurate tumor delineation, and dose estimation for effective personalized treatment. In this review, we present the technological advancements in various types of EBRT methods and discuss their clinical utility and associated limitations. We also reveal novel approaches of using biocompatible yttrium oxide scintillator-photosensitizer complex (YSM) that can generate X-ray induced cytotoxic reactive oxygen species, facilitating X-ray activated photodynamic therapy (XPDT (external beam) and/or iXPDT (internal X-ray source)) and azido-derivatives of 2-deoxy-D-glucose (2-DG) as agents for site-specific radiation-induced DNA damage.

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DNA Double-strand Breaks Induced byFractionated Neutron Beam Irradiation for Boron Neutron Capture Therapy

Abstract: Unrepaired cluster DNA damage was more prevalent after fractionated neutron irradiation than after gamma irradiation.

Cited by 7 publications

References 12 publications

Cryopreserved Stem Cells Incur Damages Due To Terrestrial Cosmic Rays Impairing Their Integrity Upon Long-Term Storage

Cryopreserved Stem Cells Incur Damages Due To Terrestrial Cosmic Rays Impairing Their Integrity Upon Long-Term Storage

Innate Immune System in the Context of Radiation Therapy for Cancer

Technological Advancements in External Beam Radiation Therapy (EBRT): An Indispensable Tool for Cancer Treatment

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