DNA excision repair and double-strand break repair gene polymorphisms and the level of chromosome aberration in children with long-term exposure to radon

Ларионов, А. В.; Sinitsky, M. Yu.; Дружинин, В. Г.; Volobaev, Valentin P.; Минина, В. И.; Asanov, Maxim А.; Meyer, A. V.; Tolochko, T. A.; Kalyuzhnaya, E. E.

doi:10.1080/09553002.2016.1186303

Cited by 10 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ionizing radiation, in addition to producing mutations mainly by gene deletion and gross chromosomal damage, can also induce epigenetic effects 4 . Residential radon exposure has been associated with DNA-repair gene polymorphisms in adults ( XpG gene Asp1104His, ADPRT gene Val762Ala, and NBS1 gene Glu185Gln polymorphisms) 16 and partly replicated in children ( XpD gene Lys751Gln, XpG gene Asp1104His and ADPRT gene Val762Ala polymorphisms) 17 , with the latter study also reporting double-strand break repair gene polymorphisms. Epigenetics describe heritable chemical modifications of DNA and chromatin affecting gene expression, and include DNA methylation, histone modifications and microRNAs which can act in concert to regulate gene expression 18 .…”

Section: Introductionmentioning

confidence: 84%

Residential exposure to radon and DNA methylation across the lifecourse: an exploratory study in the ALSPAC birth cohort

Vocht¹,

Suderman²,

Ruano-Raviña³

et al. 2019

Wellcome Open Res

View full text Add to dashboard Cite

Background: Radon (and its decay products) is a known human carcinogen and the leading cause of lung cancer in never-smokers and the second in ever-smokers. The carcinogenic mechanism from radiation is a combination of genetic and epigenetic processes, but compared to the genetic mechanisms, epigenetic processes remain understudied in humans. This study aimed to explore associations between residential radon exposure and DNA methylation in the general population. Methods: Potential residential radon exposure for 75-metre area buffers was linked to genome-wide DNA methylation measured in peripheral blood from children and mothers of the Accessible Resource for Integrated Epigenomic Studies subsample of the ALSPAC birth cohort. Associations with DNA methylation were tested at over 450,000 CpG sites at ages 0, 7 and 17 years (children) and antenatally and during middle-age (mothers). Analyses were adjusted for potential residential and lifestyle confounding factors and were determined for participants with complete data (n = 786 to 980). Results: Average potential exposure to radon was associated in an exposure-dependent manner with methylation at cg25422346 in mothers during pregnancy, with no associations at middle age. For children, radon potential exposure was associated in an exposure-dependent manner with methylation of cg16451995 at birth, cg01864468 at age 7, and cg04912984, cg16105117, cg23988964, cg04945076, cg08601898, cg16260355 and cg26056703 in adolescence. Conclusions: Residential radon exposure was associated with DNA methylation in an exposure-dependent manner. Although chance and residual confounding cannot be excluded, the identified associations may show biological mechanisms involved in early biological effects from radon exposure.

show abstract

Section: Introductionmentioning

confidence: 84%

Residential exposure to radon and DNA methylation across the lifecourse: an exploratory study in the ALSPAC birth cohort

Vocht¹,

Suderman²,

Ruano-Raviña³

et al. 2019

Wellcome Open Res

View full text Add to dashboard Cite

show abstract

“…Интересно, что значимый вклад унаследованных вариантов АкРГ в пока-затели хромосомной нестабильности наблюдается только в группе детей, контактировавших со сверхнормативны-ми дозами радона (как в шорской, так и в русской этни-ческой группе). Исходя из этого, индивидуальную дозу активных рибосомных генов, наряду с уже известными факторами риска [21,28,29], можно отнести к группе наследственных факторов, связанных с индивидуальной чувствительностью к воздействию повышенных доз из-лучения радона. Полученные результаты, наряду с дру-гими известными биомаркерами, могут быть использо-ваны при разработке системы прогноза индивидуальной радио чувствительности человека.…”

Section: Discussionunclassified

Cytogenetic effects of excessive radon exposure depending on the individual dosage of active ribosomal genes

Тимофеева

Минина

Ивановна³

et al. 2017

Ecological genetics

Self Cite

View full text Add to dashboard Cite

Background. Maintaining radon safety is one of the most critical challenges in modern ecology and genetic toxicology. Radon (222Rn) and its decay daughter products (218Po, 214Po, 214Pb and 214Bi) can interact with biological tissues and induce DNA damage. Because transcribed copies rDNA are necessary for DNA damage repair, we examined whether genomic dosages of active ribosomal genes modulate the genotoxic effects of exposure to high doses of radon. Materials and methods. Chromosome aberration assay in peripheral blood lymphocytes was performed in pupils of the boarding school of Tashtagol (Kemerovo region, Russia) with long-term resident exposure to radon (n = 345) and in childrenof the Kemerovo Region living in radiation-safe conditions (n = 233). The dose of active (transcription-capable) ribosomal gene (AcRG) in the studied groups has been analyzed using Ag-NORS staining regions of chromosomes and cytogenetic semi-quantitative evaluation method. Results. A statistically significant increase in the level of chromosome aberrations in exposure group has been revealed compared with the children of the Kemerovo Region living in radiation-safe conditions (p = 0.00001). It was found that the level of chromosomal abnormalities in Tashtagol’s children was higher in medium-dose carriers of AcRG compared to owners of a low dose (4.27 ± 0.22% vs. 3.24 ± 0.29%, p = 0.003). Perhaps the low level of chromosomal aberrations in children with low-dose AcRG is associated with an increase in cell death from damaged DNA under genotoxic exposure to radon. Conclusion. The obtained results testify to the significant contribution of the individual characteristics of ribosomal genes in the formation of genotoxic effects of exposure to high doses of radon.

show abstract

“…According to the latest WHO data published in May 2014, lung cancers deaths in Kazakhstan reached 3836 or 2.58% of total deaths. The age adjusted death rate is 26.24 per 100,000 of population ranks Kazakhstan #36 in the world [123]. Currently, Kazakhstan is in need of advanced actions to reduce lung cancer rate.…”

Section: Lung Cancer Studies In Kazakhstanmentioning

confidence: 99%

Residential Radon Exposure and Lung Cancer Risk in Kazakhstan

Bersimbaev¹,

Bulgakova²

2017

Radon

View full text Add to dashboard Cite

Many published data have demonstrated the potential of radon exposure to induce biological damage. All these studies suggest that exposure to radon and its progeny can represent a significant public health risk. Radon exposure is considered as the second cause of lung cancer and it is the first in never smokers. Many countries have depicted residential radon exposure maps in order to characterize those areas with the highest indoor radon concentrations. There are areas in Kazakhstan with a number of factors leading to natural radioactivity. The genotoxic effects of radon on population of Kazakhstan are poorly understood. These studies conducted in compliance with all requirements of genotoxic studies will provide an extensive and reliable data for a detailed radon zoning of Kazakhstan. Our review attempts to integrate data about the association between residential radon levels and morbidity of population in Kazakhstan. In addition, we tried to cover all points of the cytogenetic and molecular changes induced by radon exposure.

show abstract

DNA excision repair and double-strand break repair gene polymorphisms and the level of chromosome aberration in children with long-term exposure to radon

Abstract: The relationships with several types of cytogenetic damage suggest these three SNP (rs13181, rs17655 and rs1136410) may be considered radiosensitivity markers.

Cited by 10 publications

References 48 publications

Residential exposure to radon and DNA methylation across the lifecourse: an exploratory study in the ALSPAC birth cohort

Residential exposure to radon and DNA methylation across the lifecourse: an exploratory study in the ALSPAC birth cohort

Cytogenetic effects of excessive radon exposure depending on the individual dosage of active ribosomal genes

Residential Radon Exposure and Lung Cancer Risk in Kazakhstan

Contact Info

Product

Resources

About