DNA functionalization of colloidal particles via physisorption of azide-functionalized diblock copolymers

Abstract

DNA-coated colloids are prepared simply by physical adsorption of azide-functionalized amphiphilic diblock copolymers onto hydrophobic inorganic particles, followed by strain-promoted azide–alkyne cycloaddition (SPAAC) reaction.

Unveiling adsorption generality in polymeric macromolecules

“…In this paper, we introduced a generalised expression for the adsorption probability of whole classes of spherical and non spherical macromolecular adsorbers. Through a correct rescaling, we have shown that all adsorption probabilities fall (11). Panel (b) R sim as a function of the heuristically determined radius R rcp , as defined in eqn (12); panel (c) reports the radius R rcp plotted as a function of R th .…”

“…9,10 Due to the wide spectrum of promising applications, the materials science community has focused much of its effort on designing and developing functionalised materials at the nanoscale. Over the years, nanoparticles have been functionalised chemically -for example by choosing specific functional groups [11][12][13] -or physically -by choosing, for instance, a specific geometry for the nanocomposite. 14 Every design, while leading to different local and global properties for the nanoparticles, accounts for the interplay of a multitude of details.…”

“…Fig.7Panel (a) reports the radius R sim as a function of the scaling prediction R th as defined in eqn(11). Panel (b) R sim as a function of the heuristically determined radius R rcp , as defined in eqn(12); panel (c) reports the radius R rcp plotted as a function of R th .…”