DNA-functionalized upconversion nanoparticles as biosensors for rapid, sensitive, and selective detection of Hg<sup>2+</sup> in complex matrices

Huang, Li-Jiao; Yu, Ru‐Qin; Chu, Xia

doi:10.1039/c5an00635j

Cited by 35 publications

(12 citation statements)

References 37 publications

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“…As previously mentioned, UCNPs with large anti‐Stokes shift, weak background interference, and no photobleaching are suitable to detect some target species, such as pH, temperature, metal ions, anion, free radicals, biological molecules, and so on . Most cases of detection are based on LRET process with a few exceptional cases.…”

Section: Applications Of Upconversion Nanostructuresmentioning

confidence: 99%

Current Advances in Lanthanide‐Doped Upconversion Nanostructures for Detection and Bioapplication

2016

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Along with the development of science and technology, lanthanide‐doped upconversion nanostructures as a new type of materials have taken their place in the field of nanomaterials. Upconversion luminescence is a nonlinear optical phenomenon, which absorbs two or more photons and emits one photon. Compared with traditional luminescence materials, upconversion nanostructures have many advantages, such as weak background interference, long lifetime, low excitation energy, and strong tissue penetration. These interesting nanostructures can be applied in anticounterfeit, solar cell, detection, bioimaging, therapy, and so on. This review is focused on the current advances in lanthanide‐doped upconversion nanostructures, covering not only basic luminescence mechanism, synthesis, and modification methods but also the design and fabrication of upconversion nanostructures, like core–shell nanoparticles or nanocomposites. At last, this review emphasizes the application of upconversion nanostructure in detection and bioimaging and therapy. Learning more about the advances of upconversion nanostructures can help us better exploit their excellent performance and use them in practice.

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Section: Applications Of Upconversion Nanostructuresmentioning

confidence: 99%

Current Advances in Lanthanide‐Doped Upconversion Nanostructures for Detection and Bioapplication

2016

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“…Several nanoparticles have been used to construct fluorescence sensors including carbon dots (CDs), 116 , 149 quantum dots (QDs), 126 , 150 − 152 or up-conversion NPs. 153 Using multicolor QDs, Zhang et al ( 151 ) showed the feasibility of detecting SARS-CoV-2 using a portable system. A smartphone-based portable device is used to read a barcode-like signal to track the SARS-CoV-2 infection.…”

Section: Diagnostic Tests Of Sars-cov-2 Based On Nanomaterials and 2d...mentioning

confidence: 99%

Diagnostic Approaches For COVID-19: Lessons Learned and the Path Forward

Alafeef

Pan

2022

ACS Nano

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Coronavirus disease 2019 (COVID-19) is a transmitted respiratory disease caused by the infection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although humankind has experienced several outbreaks of infectious diseases, the COVID-19 pandemic has the highest rate of infection and has had high levels of social and economic repercussions. The current COVID-19 pandemic has highlighted the limitations of existing virological tests, which have failed to be adopted at a rate to properly slow the rapid spread of SARS-CoV-2. Pandemic preparedness has developed as a focus of many governments around the world in the event of a future outbreak. Despite the largely widespread availability of vaccines, the importance of testing has not diminished to monitor the evolution of the virus and the resulting stages of the pandemic. Therefore, developing diagnostic technology that serves as a line of defense has become imperative. In particular, that test should satisfy three criteria to be widely adopted: simplicity, economic feasibility, and accessibility. At the heart of it all, it must enable early diagnosis in the course of infection to reduce spread. However, diagnostic manufacturers need guidance on the optimal characteristics of a virological test to ensure pandemic preparedness and to aid in the effective treatment of viral infections. Nanomaterials are a decisive element in developing COVID-19 diagnostic kits as well as a key contributor to enhance the performance of existing tests. Our objective is to develop a profile of the criteria that should be available in a platform as the target product. In this work, virus detection tests were evaluated from the perspective of the COVID-19 pandemic, and then we generalized the requirements to develop a target product profile for a platform for virus detection.

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“…[68] Besides these studies, there are also some other strategies reported in literature. For example, Chu and co-workers reported a DNA-functionalized UCNPs probe to sense Hg 2+ with a detection limit of 5 × 10 −9 m [69] while some other groups employed rhodamine-derivative-functionalized upconversion nanorods to recognize Hg 2+ . [70][71][72]…”

Section: Hg 2+ Sensorsmentioning

confidence: 99%

Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

2018

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Significant progress on upconversion‐nanoparticle (UCNP)‐based probes is witnessed in recent years. Compared with traditional fluorescent probes (e.g., organic dyes, metal complexes, or inorganic quantum dots), UCNPs have many advantages such as non‐autofluorescence, high chemical stability, large light‐penetration depth, long lifetime, and less damage to samples. This article focuses on recent achievements in the usage of lanthanide‐doped UCNPs as efficient probes for biodetection since 2014. The mechanisms of upconversion as well as the luminescence resonance energy transfer process is introduced first, followed by a detailed summary on the recent researches of UCNP‐based biodetections including the detection of inorganic ions, gas molecules, reactive oxygen species, and thiols and hydrogen sulfide.

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DNA-functionalized upconversion nanoparticles as biosensors for rapid, sensitive, and selective detection of Hg²⁺ in complex matrices

Cited by 35 publications

References 37 publications

Current Advances in Lanthanide‐Doped Upconversion Nanostructures for Detection and Bioapplication

Current Advances in Lanthanide‐Doped Upconversion Nanostructures for Detection and Bioapplication

Diagnostic Approaches For COVID-19: Lessons Learned and the Path Forward

Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

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DNA-functionalized upconversion nanoparticles as biosensors for rapid, sensitive, and selective detection of Hg2+ in complex matrices

Cited by 35 publications

References 37 publications

Current Advances in Lanthanide‐Doped Upconversion Nanostructures for Detection and Bioapplication

Current Advances in Lanthanide‐Doped Upconversion Nanostructures for Detection and Bioapplication

Diagnostic Approaches For COVID-19: Lessons Learned and the Path Forward

Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems

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DNA-functionalized upconversion nanoparticles as biosensors for rapid, sensitive, and selective detection of Hg²⁺ in complex matrices