DNA image cytometry in sebaceous tumours of the Muir-Torre syndrome

Kiehl, Peter; Richter, K; Erdelkamp, J.; Herbst, Rudolf; Kapp, Alexander; Böcking, Alfred

doi:10.1046/j.1365-2133.1998.02192.x

Cited by 15 publications

(7 citation statements)

References 7 publications

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“…As has been shown for sweat gland tumours in this study and for sebaceous tumours in a previous work, 27 ICM‐DNA may be of value in detecting prospective malignancy in other cutaneous adnexal tumours as well.…”

Section: Discussionsupporting

confidence: 82%

DNA image cytometry in malignant and benign sweat gland tumours

Vogelbruch

Böcking

Rütten

et al. 2000

British Journal of Dermatology

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The histopathological differentiation between well-differentiated carcinomas and atypical adenomas of sweat gland origin may be difficult, even if immunohistochemical methods are used. Therefore, additional techniques may be helpful. We previously demonstrated that DNA image cytometry (ICM-DNA) can be useful in distinguishing between malignant and benign clear cell hidradenoma. In the present study, a larger series of sweat gland tumours, with a clear-cut diagnosis as malignant or benign on histopathological criteria, was examined by ICM-DNA. Enzymatic cell separation specimens were prepared from paraffin-embedded tissues of 18 sweat gland carcinomas (14 porocarcinomas, one classic eccrine adenocarcinoma, two microcystic adnexal carcinomas and one mostly ductal apocrine carcinoma) and 47 benign sweat gland tumours (three syringocystadenomas, five spiradenomas, 14 cylindromas, three syringomas, seven nodular hidradenomas, 10 cutaneous mixed tumours, four poromas and one apocrine hidrocystoma). Specimens were examined by ICM-DNA according to the current recommendations of the European Society for Analytical Cellular Pathology with the AutoCyte QUIC-DNA workstation using mesenchymal cells as an internal reference. DNA aneuploidy was detected by the stemline interpretation according to Böcking and/or at least three 5[c]-exceeding events. DNA aneuploidy was detected in 16 of 18 (89%) of the sweat gland carcinomas, but in none of the 47 adenomas. These results suggest that the detection of DNA aneuploidy in sweat gland tumours using ICM-DNA is a clear and specific indicator of prospective malignancy.

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Section: Discussionsupporting

confidence: 82%

DNA image cytometry in malignant and benign sweat gland tumours

Vogelbruch

Böcking

Rütten

et al. 2000

British Journal of Dermatology

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“…They critically reviewed many published reports on SA, including their own, and suggested that most of the lesions were actually SC. Since their report, several sebaceous neoplasms with discordant architectural and cytological features have been reported …”

Section: Sebaceous Neoplasmsmentioning

confidence: 99%

“…Since their report, several sebaceous neoplasms with discordant architectural and cytological features have been reported. [120][121][122] Misago et al 121 designated such cases as low-grade SC (LGSC), which was defined as follows.…”

Section: Classification Of Sebaceous Neoplasms: Low-grade Sebaceous Cmentioning

confidence: 99%

Topics in histopathology of sweat gland and sebaceous neoplasms

Ansai

2017

The Journal of Dermatology

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This article reviews several topics regarding sweat gland and sebaceous neoplasms. First, the clinicopathological characteristics of poroid neoplasms are summarized. It was recently reported that one-fourth of poroid neoplasms are composite tumors and one-fourth are apocrine type lesions. Recent progress in the immunohistochemical diagnosis of sweat gland neoplasms is also reviewed. CD117 can help to distinguish sweat gland or sebaceous tumors from other non-Merkel cell epithelial tumors of the skin. For immunohistochemical differential diagnosis between sweat gland carcinoma (SGC) other than primary cutanesous apocrine carcinoma and skin metastasis of breast carcinoma (SMBC), a panel of antibodies may be useful, including p63 (SGC + , SMBC ). Comparison of antibodies used for immunohistochemical diagnosis of sebaceous carcinoma (SC) suggests that adipophilin has the highest sensitivity and specificity. Some authors have found that immunostaining for survivin, androgen receptor and ZEB2/ SIP1 has prognostic value for ocular SC, but not extraocular SC. In situ SC is rare, especially extraocular SC, but there have been several recent reports that actinic keratosis and Bowen's disease are the source of invasive SC. Finally, based on recent reports, classification of sebaceous neoplasms into three categories is proposed, which are sebaceoma (a benign neoplasm with well-defined architecture and no atypia), borderline sebaceous neoplasm (low-grade SC; an intermediate tumor with well-defined architecture and nuclear atypia) and SC (a malignant tumor with invasive growth and evident nuclear atypia).

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“…Thus, additional methods such as DNA ICM are desirable for the assessment of malignancy in these tumours. We have recently demonstrated that DNA ICM can be helpful in identifying prospective malignancy in sebaceous tumours 12 and sweat gland tumours 13,14 . To the best of our knowledge, the present study represents the first large study on DNA ICM in follicular adnexal tumours.…”

Section: Discussionmentioning

confidence: 66%

“…DNA image cytometry (DNA ICM) has proved to be useful in identifying prospective malignancy in various cutaneous and extracutaneous tumours 9–11 . Regarding cutaneous adnexal tumours, we have demonstrated in previous studies that DNA ICM can be helpful in detecting prospective malignancy in sebaceous tumours of the Muir–Torre syndrome 12 and sweat gland tumours 13,14 . To the best of our knowledge, only two small studies of DNA ICM in follicular adnexal tumours have been conducted to date 15,16 .…”

mentioning

confidence: 99%