DNA Interaction and Cytotoxic studies on Mono/Di-Oxo and Peroxo- Vanadium (V) complexes - A Review

Kothandan, Saraswathi; Sheela, Angappan

doi:10.2174/1389557521666210308143522

Cited by 9 publications

(6 citation statements)

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“…The highest cytoprotection at the mitochondrial level in the MTT test occurred for [(+)VOL 4 ], with up to 60% of HT-22 cell viability for a 10 µM dose. The higher cytotoxicity of vanadium(V) complexes is very likely caused by the formation of peroxidovanadium(V) species after the addition of 30% H 2 O 2 , in comparison to cis-dioxidomolybdenum(VI) Schiff base complexes derived from the same chiral tetradentate amino alcohols and can be the reason for the stronger harmful effect on hippocampal cells [53]. Such properties of various vanadium compounds may emphasize their importance as promising drug candidates in chemotherapy and targeted cancer therapies, with possible relatively strong cytotoxicity and antimetastatic activity [54].…”

Section: Oxidovanadium(v) Complexes [(+)Vol 1 ] [(+)Vol 3 ] [(+)Vol 4...mentioning

confidence: 99%

Oxidovanadium(V) Schiff Base Complexes Derived from Chiral 3-amino-1,2-propanediol Enantiomers: Synthesis, Spectroscopic Studies, Catalytic and Biological Activity

Romanowski,

Budka,

Inkielewicz-Stepniak

2024

IJMS

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Oxidovanadium(V) complexes, [(+)VOL1-5] and [(–)VOL1-5], with chiral tetradentate Schiff bases, which are products of monocondensation of S(‒)-3-amino-1,2-propanediol or R(+)-3-amino-1,2-propanediol with salicylaldehyde derivatives, have been synthesized. Different spectroscopic methods, viz. 1H and 51V NMR, IR, UV-Vis, and circular dichroism, as well as elemental analysis, have been used for their detailed characterization. Furthermore, the epoxidation of styrene, cyclohexene, and two monoterpenes, S(‒)-limonene and (‒)-α-pinene, using two oxidants, aqueous 30% H2O2 or tert-butyl hydroperoxide (TBHP) in decane, has been studied with catalytic amounts of all complexes. Finally, biological cytotoxicity studies have also been performed with these oxidovanadium(V) compounds for comparison with cis-dioxidomolybdenum(VI) Schiff base complexes with the same chiral ligands, as well as to determine the cytoprotection against the oxidative damage caused by 30% H2O2 in the HT-22 hippocampal neuronal cells in the range of their 10–100 μM concentration.

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Section: Oxidovanadium(v) Complexes [(+)Vol 1 ] [(+)Vol 3 ] [(+)Vol 4...mentioning

confidence: 99%

Oxidovanadium(V) Schiff Base Complexes Derived from Chiral 3-amino-1,2-propanediol Enantiomers: Synthesis, Spectroscopic Studies, Catalytic and Biological Activity

Romanowski,

Budka,

Inkielewicz-Stepniak

2024

IJMS

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“…Vanadium can have direct interactions with DNA [ 139 , 140 , 141 , 142 ] or with proteins associated with DNA (histones), as well as indirect consequences through the generation of ROS. The direct interaction of vanadium complexes with DNA often reflects the ability of vanadium compounds to be intercalated into the 3D structure of the DNA double helix [ 143 , 144 , 145 , 146 , 147 ]. Vanadium salts and compounds have been shown to interact directly with proteins as discussed in Section 2.6 .…”

Section: Effects Of Vanadium and Lpo On Plasma Membranes Organelles M...mentioning

confidence: 99%

Biological Consequences of Vanadium Effects on Formation of Reactive Oxygen Species and Lipid Peroxidation

Aureliano

Sousa‐Coelho

Dolan

et al. 2023

IJMS

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Lipid peroxidation (LPO), a process that affects human health, can be induced by exposure to vanadium salts and compounds. LPO is often exacerbated by oxidation stress, with some forms of vanadium providing protective effects. The LPO reaction involves the oxidation of the alkene bonds, primarily in polyunsaturated fatty acids, in a chain reaction to form radical and reactive oxygen species (ROS). LPO reactions typically affect cellular membranes through direct effects on membrane structure and function as well as impacting other cellular functions due to increases in ROS. Although LPO effects on mitochondrial function have been studied in detail, other cellular components and organelles are affected. Because vanadium salts and complexes can induce ROS formation both directly and indirectly, the study of LPO arising from increased ROS should include investigations of both processes. This is made more challenging by the range of vanadium species that exist under physiological conditions and the diverse effects of these species. Thus, complex vanadium chemistry requires speciation studies of vanadium to evaluate the direct and indirect effects of the various species that are present during vanadium exposure. Undoubtedly, speciation is important in assessing how vanadium exerts effects in biological systems and is likely the underlying cause for some of the beneficial effects reported in cancerous, diabetic, neurodegenerative conditions and other diseased tissues impacted by LPO processes. Speciation of vanadium, together with investigations of ROS and LPO, should be considered in future biological studies evaluating vanadium effects on the formation of ROS and on LPO in cells, tissues, and organisms as discussed in this review.

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“…Some of these uses are supported by mechanistic information for V 4+ that indicate it is a protein tyrosine phosphatase inhibitor. 12…”

Section: Production Use and Human Exposurementioning

confidence: 99%

NTP Technical Report on the Toxicity Studies of Sodium Metavanadate (CASRN 13718-26-8) and Vanadyl Sulfate (CASRN 27774-13-6) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6C3F1/N Mice

2023

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Oral human exposure to vanadium may occur due to its presence in food and drinking water and its use in dietary supplements. The most prevalent oxidation states of vanadium in food and drinking water have been characterized as tetravalent and pentavalent. Vanadyl sulfate and sodium metavanadate were selected as representative tetravalent (V 4+ ) and pentavalent (V 5+ ) test articles for these studies, respectively. To assess the potential for oral toxicity of vanadium compounds with differing oxidation states under similar test conditions, the 3-month National Toxicology Program (NTP) toxicity studies of sodium metavanadate and vanadyl sulfate in male and female Sprague Dawley (Hsd:Sprague Dawley ® SD ® ) rats (including perinatal exposure) and in B6C3F1/N mice. Drinking water concentrations for sodium metavanadate (0, 31.3, 62.5, 125, 250, and 500 mg/L) and vanadyl sulfate (0, 21.0, 41.9, 83.8, 168, and 335 mg/L) were selected on the basis of previously published 14-day drinking water studies conducted as part of the NTP vanadium research program.

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DNA Interaction and Cytotoxic studies on Mono/Di-Oxo and Peroxo- Vanadium (V) complexes - A Review

Cited by 9 publications

References 0 publications

Oxidovanadium(V) Schiff Base Complexes Derived from Chiral 3-amino-1,2-propanediol Enantiomers: Synthesis, Spectroscopic Studies, Catalytic and Biological Activity

Oxidovanadium(V) Schiff Base Complexes Derived from Chiral 3-amino-1,2-propanediol Enantiomers: Synthesis, Spectroscopic Studies, Catalytic and Biological Activity

Biological Consequences of Vanadium Effects on Formation of Reactive Oxygen Species and Lipid Peroxidation

NTP Technical Report on the Toxicity Studies of Sodium Metavanadate (CASRN 13718-26-8) and Vanadyl Sulfate (CASRN 27774-13-6) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6C3F1/N Mice

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