DNA Interaction, in vitro Antibacterial and Cytotoxic Activities of Ru(III) Heterochelates

Karia, Parag S.; Vekariya, Pankaj A.; Patidar, Anshul P.; Kanthecha, Darshana N.; Bhatt, Bhupesh S.; Patel, Mohan N.

doi:10.17344/acsi.2019.5159

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…The absorption spectra for the ligand, 3, 4, and their iron(III) complex, 3a, 4a are shown in Figure 5. As can be seen from Figure 5, with the addition of DNA, the absorption density of complexes (3a, 4a) and ligand (3,4) decreases gradually, and absorption spectra with similar profiles were obtained for all. When the absorption spectrum obtained for the ligand (3) is examined in detail, it is seen that 15% hypochromite around 347 nm is accompanied by a very small 0.5 nm redshift.…”

Section: Dna Binding Studiessupporting

confidence: 57%

“…Analytical and physical data of mononuclear Fe(III) complexes (3a and 4a) are presented in the experimental section. The azo-oxime type ligands (3,4) were synthesized by the condensation of related aldehyde (1 or 2) with hydroxylamine hydrochloride in a 1:1 molar ratio in pyridine ( Figure 1). Two deprotonated azo-oxime ligands were coordinated to a single iron(III) center through the NO donor atoms.…”

Section: Synthesismentioning

confidence: 99%

“…So, they might affect as antitumor reagents by preventing cell growth and division [3]. Therefore, examination of the DNA binding ability of the transition metal complexes is an important research topic [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Iron(III) Complexes Derived From Azo-Containing Salicylaldoxime Ligands: Synthesis, Structures and Biological Evaluations

Serbest¹,

Dural²,

Ayvaz³

et al. 2021

El-Cezeri Fen Ve Mühendislik Dergisi

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Two novel mononuclear Fe(III) complexes derived from azo-containing salicylaldoxime ligands were synthesized and characterized by elemental analyses, spectroscopic data i.e. IR, 1H NMR, UV-Vis, electrospray ionization mass spectra, molar conductivity, and magnetic susceptibility measurements. Both the experimental and theoretical results strongly suggest that the ligands have a major contribution to the azo enol imine form instead of the hydrazo keto imine and azo keto amine forms in solution/solid-state. The electronic spectra of the ligands and their iron(III) complexes were calculated theoretically for the band assignments by using DFT and TD-DFT/CPCM methods. DNA binding, cleavage, and antioxidative activities of the investigated compounds were studied. It has been shown that the ligands and their iron (III) complexes tested bind to DNA via the intercalative mode. It was observed that all molecules tested inhibited topoisomerase I almost to the same degree. One of the most striking results among the antioxidant activity tests is that the hydroxyl radical scavenging activities of the ligands and complexes are higher than the standard antioxidant mannitol.

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Section: Dna Binding Studiessupporting

confidence: 57%

Section: Synthesismentioning

confidence: 99%

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Iron(III) Complexes Derived From Azo-Containing Salicylaldoxime Ligands: Synthesis, Structures and Biological Evaluations

Serbest¹,

Dural²,

Ayvaz³

et al. 2021

El-Cezeri Fen Ve Mühendislik Dergisi

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“…Furthermore, to clarify the chelating mode of ruthenium, the Ru@RF obtained from the Ru@RF‐silica directly by the silica‐removal without a carbonization treatment was characterized by the FTIR spectrum. As shown in Figure S3, Supporting Information, a peak at 555 cm −1 corresponding to ν(Ru–O) was found, [ 15,16 ] suggesting that the ruthenium precursor might be anchored to phenolic hydroxyl groups during the assembly process.…”

Section: Resultsmentioning

confidence: 99%

Ultrafine Ruthenium Clusters Shell‐Embedded Hollow Carbon Spheres as Nanoreactors for Channel Microenvironment‐Modulated Furfural Tandem Hydrogenation

Xiong

et al. 2022

Small

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Rationally modulating the catalytic microenvironment is important for targeted induction of specific molecular behaviors to fulfill complicated catalytic purposes. Herein, a metal pre‐chelating assisted assembly strategy is developed to facilely synthesize the hollow carbon spheres with ultrafine ruthenium clusters embedded in pore channels of the carbon shell (Ru@Shell‐HCSs), which can be employed as nanoreactors with preferred electronic and geometric catalytic microenvironments for the efficient tandem hydrogenation of biomass‐derived furfural toward 2‐methylfuran. The channel‐embedding structure is proved to confer the ultrafine ruthenium clusters with an electron‐deficient property via a reinforced interfacial charge transfer mechanism, which prompts the hydrogenolysis of intermediate furfuryl alcohol during the tandem reaction, thus resulting in an enhanced 2‐methylfuran generation. Meanwhile, lengthening the shell pore channel can offer reactant molecules with a prolonged diffusion path, and correspondingly a longer retention time in the channel, thereafter delivering an accelerated tandem hydrogenation progression. This paper aims to present a classic case that emphasizes the critical role of precisely controlling the catalytic microenvironment of the metal‐loaded hollow nanoreactors in coping with the arduous challenges from multifunctional catalyst‐driven complex tandem reactions.

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“…Firstly, S. aureus cells that were intervened were 31.25 µg/mL or 62.5 µg/mL MA, marked as experimentational groups, and then they were intervened by DMSO, marked as a control group, which was then incubated, harvested, and disrupted by methods mentioned above. After sonification and incubation at 37 °C for 20 h, and centrifuging at 5000 r/min for 10 min, the activities of SDH and MDH in the supernatants were detected by the SDH and MDH activity detection kit [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

Antibacterial Activity and Mechanism of Madecassic Acid against Staphylococcus aureus

2023

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Antibacterial resistance has become one of the most serious problems threating global health. To overcome this urgent problem, many scientists have paid great attention to developing new antibacterial drugs from natural products. Hence, for exploring new antibacterial drugs from Chinese medicine, a series of experiments were carried out for verifying and elucidating the antibacterial activity and mechanisms of madecassic acid (MA), which is an active triterpenoid compound isolated from the traditional Chinese medicine, Centella asiatica. The antibacterial activity was investigated through measuring the diameter of the inhibition zone, the minimum inhibitory concentration (MIC), the growth curve, and the effect on the bacterial biofilm, respectively. Meanwhile, the antibacterial mechanism was also discussed from the aspects of cell wall integrity variation, cell membrane permeability, and the activities of related enzymes in the respiratory metabolic pathway before and after the intervention by MA. The results showed that MA had an inhibitory effect on eight kinds of pathogenic bacteria, and the MIC values for Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Bacillus megaterium were 31.25, 62.5, 250, 125, 62.5, and 62.5 µg/mL, respectively. For instance, 31.25 µg/mL MA could inhibit the growth of Staphylococcus aureus within 28 h. The antibacterial mechanism experiments confirmed that MA could destroy the integrity of the cell membrane and cell wall of Staphylococcus aureus, causing the leakage of macromolecular substances, inhibiting the synthesis of soluble proteins, reducing the activities of succinate dehydrogenase and malate dehydrogenase, and interacting with DNA, leading to the relaxation and ring opening of supercoiled DNA. Besides, the activities of DNA topoisomerase I and II were both inhibited by MA, which led to the cell growth of Staphylococcus aureus being repressed. This study provides a theoretical basis and reference for the application of MA in the control and inhibition of food-borne Staphylococcus aureus.

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DNA Interaction, in vitro Antibacterial and Cytotoxic Activities of Ru(III) Heterochelates

Cited by 4 publications

References 29 publications

Iron(III) Complexes Derived From Azo-Containing Salicylaldoxime Ligands: Synthesis, Structures and Biological Evaluations

Iron(III) Complexes Derived From Azo-Containing Salicylaldoxime Ligands: Synthesis, Structures and Biological Evaluations

Ultrafine Ruthenium Clusters Shell‐Embedded Hollow Carbon Spheres as Nanoreactors for Channel Microenvironment‐Modulated Furfural Tandem Hydrogenation

Antibacterial Activity and Mechanism of Madecassic Acid against Staphylococcus aureus

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