DNA interaction, in vivo and in vitro cytotoxicity, reactive oxygen species, lipid peroxidation of –N, S donor Re(I) metal complexes

Varma, Reena R.; Pandya, Juhee G.; Sharma, Jyoti; Pathak, Chandramani; Patel, Mohan N.

doi:10.1007/s11030-020-10040-2

Cited by 8 publications

(2 citation statements)

References 41 publications

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“…Five thiophene-substituted pyrazolines were used as N,S-donor ligands in the synthesis of Re(I) complexes with proposed structure 259 (Figure 31), which were found to be more potent than the corresponding ligands against a panel of bacterial strains. [239] Com- (Figure 31) upon reaction with halide-bridged arene ruthenium, rhodium and iridium precursors. [240] One mononuclear complex 260 and three dinuclear complexes 261 had MIC = 0.125 mg/ml against S.…”

Section: Antimicrobial Activity Of Metal Complexes Based On Thiophene...mentioning

confidence: 99%

“…Five thiophene‐substituted pyrazolines were used as N , S ‐donor ligands in the synthesis of Re(I) complexes with proposed structure 259 (Figure 31), which were found to be more potent than the corresponding ligands against a panel of bacterial strains. [ 239 ] Complexation improved the antibacterial activity of the ligands (MIC values from 322 to 265 μM) threefold to fivefold and the most potent complexes were compounds 259 (R = Br or NO 2 ) against S. aureus and B. subtilis , 259 (R = CH 3 ) against S. marcescens and 259 (R = Cl) against P. aeruginosa and E. coli .…”

Section: Antimicrobial Activity Of Metal Complexes Based On Thiophene...mentioning

confidence: 99%

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Thiophene‐containing compounds with antimicrobial activity

Roman¹

2022

Archiv der Pharmazie

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Thiophene, as a member of the group of five-membered heterocycles containing one heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the accurate positioning of various functionalities onto the thiophene ring. This review provides a comprehensive, systematic and detailed account of the developments in the field of antimicrobial compounds featuring at least one thiophene ring in their structure, over the last decade.

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Section: Antimicrobial Activity Of Metal Complexes Based On Thiophene...mentioning

confidence: 99%

Section: Antimicrobial Activity Of Metal Complexes Based On Thiophene...mentioning

confidence: 99%

Thiophene‐containing compounds with antimicrobial activity

Roman¹

2022

Archiv der Pharmazie

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Fluorescence, DNA Interaction and Cytotoxicity Studies of 4,5-Dihydro-1H-Pyrazol-1-Yl Moiety Based Os(IV) Compounds: Synthesis, Characterization and Biological Evaluation

et al. 2021

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Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitors

et al. 2021

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Transmembrane protease serine-2 (TMPRSS2) is a cell-surface protein expressed by epithelial cells of specific tissues including those in the aerodigestive tract. It helps the entry of novel coronavirus (n-CoV) or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the host cell. Successful inhibition of the TMPRSS2 can be one of the crucial strategies to stop the SARS-CoV-2 infection. In the present study, a set of bioactive molecules from Morus alba Linn. were screened against the TMPRSS2 through two widely used molecular docking engines such as Autodock vina and Glide. Molecules having a higher binding affinity toward the TMPRSS2 compared to Camostat and Ambroxol were considered for in-silico pharmacokinetic analyses. Based on acceptable pharmacokinetic parameters and drug-likeness, finally, five molecules were found to be important for the TMPRSS2 inhibition. A number of bonding interactions in terms of hydrogen bond and hydrophobic interactions were observed between the proposed molecules and ligand-interacting amino acids of the TMPRSS2. The dynamic behavior and stability of best-docked complex between TRMPRSS2 and proposed molecules were assessed through molecular dynamics (MD) simulation. Several parameters from MD simulation have suggested the stability between the protein and ligands. Binding free energy of each molecule calculated through MM-GBSA approach from the MD simulation trajectory suggested strong affection toward the TMPRSS2. Hence, proposed molecules might be crucial chemical components for the TMPRSS2 inhibition. Graphic abstract

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DNA interaction, in vivo and in vitro cytotoxicity, reactive oxygen species, lipid peroxidation of –N, S donor Re(I) metal complexes

Cited by 8 publications

References 41 publications

Thiophene‐containing compounds with antimicrobial activity

Thiophene‐containing compounds with antimicrobial activity

Fluorescence, DNA Interaction and Cytotoxicity Studies of 4,5-Dihydro-1H-Pyrazol-1-Yl Moiety Based Os(IV) Compounds: Synthesis, Characterization and Biological Evaluation

Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitors

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