DNA interactions and cytotoxic studies of cis-platin analogues of substituted 2,2′-bipyridines

A water-soluble Pd(ii) complex with a terpyridine ligand: experimental and molecular modeling studies of the interaction with DNA and BSA; and in vitro cytotoxicity investigations against five human cancer cell lines

“…Some Pd(II) and Pt(II) complexes that bind to DNA via a covalent binding mode showed similar results. [75][76][77] 2.2.4. DNA cleavage studies.…”

Bipyridine-containing π-conjugated polymers bearing optically active amide groups: mechanistic aspects of formation of chiral higher-order structures

“…In the present study, Pt(DMSO) 2 Cl 2 was employed as a metal complex because it readily undergoes ligand exchange with 2,2′-bipyridine derivatives to give Pt(bipyridine)Cl 2 derivatives 45,46 exhibiting catalytic activity and cytotoxicity. 47–50 The coordination of poly( 1–2 ) to Pt(DMSO) 2 Cl 2 was monitored by CD and UV–vis absorption spectroscopy. First, one equivalent of Pt(DMSO) 2 Cl 2 was added to a solution of poly( 1–2 ) in CHCl 2 CHCl 2 ( c = 0.4 mM) as illustrated in Scheme 2.…”

“…In the present study, Pt(DMSO) 2 Cl 2 was employed as a metal complex because it readily undergoes ligand exchange with 2,2′-bipyridine derivatives to give Pt(bipyridine)Cl 2 derivatives 45,46 exhibiting catalytic activity and cytotoxicity. [47][48][49][50] The coordination of poly . Pt.…”

Synthesis, Computational studies, DNA-binding and cytotoxicity of 4-Thiazolidonone-cyclopropyl hybrid

“…It is well known fact that non-covalent binding and covalent binding are characterized by bathochromism and hypochromism and hyperchromism [25]. The lowering of hypochromicity with no bathochromic shift describes the electrostatic interaction of a compound with DNA [26,27]. From the Fig.…”