2020
DOI: 10.1002/aoc.6094
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DNA interactive and selective anticancer activity studies of copper(II) complexes decorated water‐soluble porphyrin

Abstract: Cancer is one of the diseases that seriously threaten the health of peoples. As a representative of metal drugs, cisplatin has considerable promise for the treatment of cancer. However, side effects are one of major problems for cisplatin due to their poor selectivity for cancer cells. We report here, for the first time, the syntheses of three new water‐soluble porphyrin‐modified copper(II) complexes Cu‐P1, Cu‐P2, and Cu‐P3. Results from calf thymus DNA (ct‐DNA)‐binding efficiency tests show that three copper(… Show more

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References 84 publications
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