DNA Markers from Genome-Wide Association Studies of Cardiovascular Diseases

Khrunin, Andrey; Алиев, А М; Limborska, Svetlana A.

doi:10.3103/s0891416818040031

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2021

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“…The project comprises one the most comprehensively characterized set of populations with detailed history about each of them [20]. For our purposes we selected CEU population because its genotype data had been shown to be appropriate for selection of loci to assess genetic variability in the most European populations, including those living in Russia [21][22][23][24]. We extracted the required set of SNPs from the bulk of CEU genotype data using VCFtools (0.1.15) [25].…”

Section: Methodsmentioning

confidence: 99%

A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes

Khvorykh

Khrunin

Stavchansky

et al. 2021

Genes

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In this paper we propose a workflow for studying the genetic architecture of ischemic stroke outcomes. It develops further the candidate gene approach. The workflow is based on the animal model of brain ischemia, comparative genomics, human genomic variations, and algorithms of selection of tagging single nucleotide polymorphisms (tagSNPs) in genes which expression was changed after ischemic stroke. The workflow starts from a set of rat genes that changed their expression in response to brain ischemia and results in a set of tagSNPs, which represent other SNPs in the human genes analyzed and influenced on their expression as well.

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