DNA methylation: A new regulator of phenolic acids biosynthesis in Salvia miltiorrhiza

Yang, Dongfeng; Huang, Zhicheng; Jin, Weibo; Xia, Pengguo; Jia, Qiaojun; Yang, Zhenshan; Hou, Zhuoni; Zhang, Haihua; Ji, Wei; Han, Ru

doi:10.1016/j.indcrop.2018.07.046

Cited by 46 publications

(39 citation statements)

References 56 publications

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“…These organic molecules isolated from terrestrial plants are the most studied, and their syntheses have an important role in the protection against pathogens, unfavorable temperature and pH, saline stress, heavy metal stress, and UVB and UVA radiation [3]. Secondary metabolism reflects plant environments more closely than primary metabolism [4]. There are three principal kinds of secondary metabolites biosynthesized by plants: phenolic compounds, terpenoids/ isoprenoids, and alkaloids and glucosinolates (nitrogen-or sulfur-containing molecules, respectively) [5].…”

Section: Introductionmentioning

confidence: 99%

Shikimic Acid Pathway in Biosynthesis of Phenolic Compounds

Santos-Sánchez¹,

Salas-Coronado²,

Hernández-Carlos³

et al. 2019

Plant Physiological Aspects of Phenolic Compounds

147

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Phenolic compounds are secondary metabolites found most abundantly in plants. These aromatic molecules have important roles, as pigments, antioxidants, signaling agents, the structural element lignan, and as a defense mechanism. The expression of phenolic compounds is promoted by biotic and abiotic stresses (e.g., herbivores, pathogens, unfavorable temperature and pH, saline stress, heavy metal stress, and UVB and UVA radiation). These compounds are formed via the shikimate pathway in higher plants and microorganisms. The enzymes responsible for the regulation of phenolic metabolism are known, and shikimic acid is a central metabolite. The shikimate pathway consists of seven reaction steps, beginning with an aldol-type condensation of phosphoenolpyruvic acid (PEP) from the glycolytic pathway, and D-erythrose-4-phosphate, from the pentose phosphate cycle, to produce 3-deoxy-D-arabino-heptulosonic acid 7-phosphate (DAHP). A key branchpoint compound is chorismic acid, the final product of the shikimate pathway. The shikimate pathway is described in this chapter, as well as factors that induce the synthesis of phenolic compounds in plants. Some representative examples that show the effect of biotic and abiotic stress on the production of phenolic compounds in plants are discussed.

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Section: Introductionmentioning

confidence: 99%

Shikimic Acid Pathway in Biosynthesis of Phenolic Compounds

Santos-Sánchez¹,

Salas-Coronado²,

Hernández-Carlos³

et al. 2019

Plant Physiological Aspects of Phenolic Compounds

147

View full text Add to dashboard Cite

show abstract

“…The model of regulation of secondary metabolism by DNA methylation. Source:Yang et al (2018).within or outside of the gene is highly dependent upon the type of methylation Hseih et al (2011). reported a further support for the notion of the epigenomes as a drug target and a new set of tools for the design of TCM prescriptions Amarger et al (2014).…”

mentioning

confidence: 85%

“…DNA methylation suppresses the expression of harmful DNA sequence such as endogenous retroviral genes that have been integrated into the host genome during evolution (Jaenisch and Bird, 2003). Cyotosine methylation plays important roles in development and stress resistance in plants (Yang et al, 2018). The levels of genomic DNA methylation in plants are coordinately regulated by both methylation and demethylation (Chinnusamy and Zhu, 2009;Deleris et al, 2016).…”

Section: Traditional Chinese Medicine Epigenetics and Dna Methylationmentioning

confidence: 99%

“…Xiao et al (2006) stated that DNA methylation regulates gene transcription over large regions of the genome, and can be maintained throughout life cycles and over various generations. Yang et al (2018) announced that DNA methylation regulates the expression of key genes involved in phenolic acids biosynthesis to affect phenolic acids production in Salvia miltiorrhiza. They have also reported the roles of DNA methylation on phenolic acids accumulation will provide new perceptions on the regulation of secondary metabolism in plants.…”

Section: Role Of Epigenetics and Dna Methylation In Crop Improvementmentioning

confidence: 99%

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DNA methylation as the most important content of epigenetics in traditional Chinese herbal medicine

Shahrajabian¹,

Sun²,

Cheng³

2019

J. Med. Plants Res.

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Traditional Chinese medicine is commonly used in China and so many other Asian and western Countries. Epigenetics relates to heritable alternations in chromatin architecture that do not involve changes in the underlying DNA sequence but profoundly affect gene expression and impact cellular function. Epigenetic regulation is attained by specific mechanisms involving DNA methylation, histone posttranslational modifications and the action of noncoding RNAs. Epigenetic variations also involved in the control of plant developmental processes and contribute in shaping phenotypic plasticity to the environment. Epigenetics has considerable impact on evolution and epigenetic epidemiology which has shown the intricate function between the environment and epigenetics. DNA methylation is an epigenetic mechanism that regulates gene expression and may affect plant growth, development and acclimation. DNA methylation is associated with gene expression and morphological variation. Plants, utilization of the epigenetic approach are used to manage and resist the fungal, bacterial and others biotic stresses; microbes, also employ epigenetic mechanisms to modify growth and pathogenicity, leading to resistance against plant-host immune system. DNA methylation is a chemical modification process where the methyltransderass (DNMTs) are catalyzed by selective addition of methyl groups to form 5-methylcytosine in CpG sequences. A mixture of herbs and fruits used in traditional Chinese medicine maybe use to decline diseases by adding and removing epigenetic marks on DNA. Epigenetics has been introduced to the area of TCM recently, which resulting in the hypothesis of an epigenetic role in the modern pharmacology of TCM prescriptions. Epigenetics is the partial material basis of TCM syndrome diversity, and the microscopic index of epigenetics can be an important supplement to the macroscopic syndrome differentiation of TCM syndromes. The role of epigenetic information is in developmental gene regulation, natural variation of gene expression levels, and response to the environment. The significant attention has started about the potential for epigenetic information to contribute to heritable variation in many species, even traditional Chinese herbs.

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“…For example, variations in methylation profiles have been shown to vary between wild and cultivated ginseng and were associated with differential specialized metabolite accumulation [ 34 ]. In addition, inhibitors of DNA methylation are able to increase phenolic product biosynthesis in Salvia miltiorrhiza (Bunge) hairy root cultures [ 35 ]. Finally, a correlation was made between methylation state and Benzoisoquinoline Indole Alkaloids in different organs and cultivars of opium poppy [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation

Bernonville

Maury

Delaunay

et al. 2020

IJMS

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Catharanthus roseus produces a wide spectrum of monoterpene indole alkaloids (MIAs). MIA biosynthesis requires a tightly coordinated pathway involving more than 30 enzymatic steps that are spatio-temporally and environmentally regulated so that some MIAs specifically accumulate in restricted plant parts. The first regulatory layer involves a complex network of transcription factors from the basic Helix Loop Helix (bHLH) or AP2 families. In the present manuscript, we investigated whether an additional epigenetic layer could control the organ-, developmental- and environmental-specificity of MIA accumulation. We used Whole-Genome Bisulfite Sequencing (WGBS) together with RNA-seq to identify differentially methylated and expressed genes among nine samples reflecting different plant organs and experimental conditions. Tissue specific gene expression was associated with specific methylation signatures depending on cytosine contexts and gene parts. Some genes encoding key enzymatic steps from the MIA pathway were found to be simultaneously differentially expressed and methylated in agreement with the corresponding MIA accumulation. In addition, we found that transcription factors were strikingly concerned by DNA methylation variations. Altogether, our integrative analysis supports an epigenetic regulation of specialized metabolisms in plants and more likely targeting transcription factors which in turn may control the expression of enzyme-encoding genes.

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DNA methylation: A new regulator of phenolic acids biosynthesis in Salvia miltiorrhiza

Cited by 46 publications

References 56 publications

Shikimic Acid Pathway in Biosynthesis of Phenolic Compounds

Shikimic Acid Pathway in Biosynthesis of Phenolic Compounds

DNA methylation as the most important content of epigenetics in traditional Chinese herbal medicine

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation

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