2022
DOI: 10.1530/erc-22-0145
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DNA methylation is a comprehensive marker for pediatric adrenocortical tumors

Abstract: Children diagnosed with adrenocortical tumors (pACT) have variable outcomes and, to date, the disease lacks robust prognostic biomarkers. The prognostic potential of tumor methylation has been demonstrated in several cancers. We aimed to evaluate the pACT methylation profile and its association with disease presentation and survival. In this cross-sectional study, we accessed the DNA methylation (MethylationEPIC Array, Illumina) of 57 primary pACT from Southeastern Brazil and the respective patients’ clinicopa… Show more

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Cited by 3 publications
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“…The gene silencing caused by aberrant promoter methylation has been demonstrated in oncogenesis and progression, which showed the potential as a prognostic or therapeutic biomarker. [25][26][27] The present study identified that the promoter methylation levels of CSF3R…”
Section: Discussionmentioning
confidence: 51%
“…The gene silencing caused by aberrant promoter methylation has been demonstrated in oncogenesis and progression, which showed the potential as a prognostic or therapeutic biomarker. [25][26][27] The present study identified that the promoter methylation levels of CSF3R…”
Section: Discussionmentioning
confidence: 51%
“…Bueno et al 30 demonstraram, em outro ensaio, que a hipermetilação do DNA em portadores de TACp representou fator de prognóstico reservado. Foram constatados dois padrões de metilação, TACp-1 observado em crianças com maior idade ao diagnóstico, mais propensos a serem portadores de carcinomas e doença não localizada, avançada, recorrente ou metastática.…”
Section: Ações Em Doenças Autoimunes Tumorais Infectocontagiosasunclassified