DNA methylation markers in peripheral blood for psoriatic arthritis

Deng, Min; Y, Su; Wu, Ruifang; Li, Siying; Zhu, Yanshan; Tang, Guishao; Shi, Xiaoli; Zhou, Tian; Zhao, Ming; Lu, Qianjin

doi:10.1016/j.jdermsci.2022.11.001

Cited by 9 publications

(3 citation statements)

References 46 publications

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“…Some studies have suggested that DNA methylation may be a therapeutic target for psoriasis, as some drugs can modulate DNA methylation, affecting the expression of genes involved in inflammation and immune responses. 321,325,326 Wnt inhibitory factor-1 (WIF1) is a molecule that inhibits the Wnt signaling pathway to regulate cell proliferation and differentiation. It is found that abnormal DNA methylation of WIF1 promoter can reduce its expression, resulting in the proliferation of keratinocytes and the production of IL-8.…”

Section: Epigenetic Regulationmentioning

confidence: 99%

Signaling pathways and targeted therapies for psoriasis

Guo,

Zhang,

Lin

et al. 2023

Sig Transduct Target Ther

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Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on individuals, health systems, and society worldwide. With the immunological pathologies and pathogenesis of psoriasis becoming gradually revealed, the therapeutic approaches for this disease have gained revolutionary progress. Nevertheless, the mechanisms of less common forms of psoriasis remain elusive. Furthermore, severe adverse effects and the recurrence of disease upon treatment cessation should be noted and addressed during the treatment, which, however, has been rarely explored with the integration of preliminary findings. Therefore, it is crucial to have a comprehensive understanding of the mechanisms behind psoriasis pathogenesis, which might offer new insights for research and lead to more substantive progress in therapeutic approaches and expand clinical options for psoriasis treatment. In this review, we looked to briefly introduce the epidemiology, clinical subtypes, pathophysiology, and comorbidities of psoriasis and systematically discuss the signaling pathways involving extracellular cytokines and intracellular transmission, as well as the cross-talk between them. In the discussion, we also paid more attention to the potential metabolic and epigenetic mechanisms of psoriasis and the molecular mechanistic cascades related to its comorbidities. This review also outlined current treatment for psoriasis, especially targeted therapies and novel therapeutic strategies, as well as the potential mechanism of disease recurrence.

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Section: Epigenetic Regulationmentioning

confidence: 99%

Signaling pathways and targeted therapies for psoriasis

Guo,

Zhang,

Lin

et al. 2023

Sig Transduct Target Ther

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show abstract

“…DNA methylation can also play a role in the development of psoriatic arthritis: different DNA methylation patterns in CD8+ T cells may facilitate distinction of purely cutaneous psoriasis and psoriatic arthritis [ 115 , 116 , 117 ]. The published studies are few and the size samples small, so further research on this issue is needed.…”

Section: Resultsmentioning

confidence: 99%

Genetic and Epigenetic Mechanisms of Psoriasis

Arrom

Puig

2023

Genes

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Psoriasis is a disease involving the innate and adaptative components of the immune system, and it is triggered by environmental factors in genetically susceptible individuals. However, its physiopathology is not fully understood yet. Recent technological advances, especially in genome and epigenome-wide studies, have provided a better understanding of the genetic and epigenetic mechanisms to determine the physiopathology of psoriasis and facilitate the development of new drugs. This review intends to summarize the current evidence on genetic and epigenetic mechanisms of psoriasis.

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“…Methylation of insulin receptor substrate 1 ( IRS1 ) and p16INK4a were significantly changed and can be potential biomarkers [ 52 , 53 ]. A combination of 6 differential methylation sites can be used to distinguish PsA, psoriasis vulgaris, rheumatoid arthritis and healthy individuals with high sensitivity and specificity [ 54 ]. The wingless-related integration site ( Wnt ) passway is important in psoriasis, and the methylation of Wnt inhibitory factor 1 ( WIF1 ) has been proven upregulated in psoriasis.…”

Section: Epigenomicsmentioning

confidence: 99%

The new era of immune skin diseases: Exploring advances in basic research and clinical translations

Zhang,

Mei,

Zhao

et al. 2024

Journal of Translational Autoimmunity

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DNA methylation markers in peripheral blood for psoriatic arthritis

Cited by 9 publications

References 46 publications

Signaling pathways and targeted therapies for psoriasis

Signaling pathways and targeted therapies for psoriasis

Genetic and Epigenetic Mechanisms of Psoriasis

The new era of immune skin diseases: Exploring advances in basic research and clinical translations

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