DNA methylation studies in cattle

Halušková, Jana; Holečková, Beáta; Staničová, Jana

doi:10.1007/s13353-020-00604-1

Cited by 11 publications

(12 citation statements)

References 130 publications

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“…In this study, we found that gene expression and DNA methylation were negatively correlated only in regulatory regions around TSSs. A positive correlation was found between gene expression and DNA methylation in gene bodies near TTSs, which is in agreement with our previous study in pigs [ 17 ] as well as previous studies in humans and cattle [ 24 , 25 ].…”

Section: Discussionsupporting

confidence: 93%

DNA Demethylation of Myogenic Genes May Contribute to Embryonic Leg Muscle Development Differences between Wuzong and Shitou Geese

Zhang

Zhu

et al. 2023

IJMS

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Skeletal muscle development from embryonic stages to hatching is critical for poultry muscle growth, during which DNA methylation plays a vital role. However, it is not yet clear how DNA methylation affects early embryonic muscle development between goose breeds of different body size. In this study, whole genome bisulfite sequencing (WGBS) was conducted on leg muscle tissue from Wuzong (WZE) and Shitou (STE) geese on embryonic day 15 (E15), E23, and post-hatch day 1. It was found that at E23, the embryonic leg muscle development of STE was more intense than that of WZE. A negative correlation was found between gene expression and DNA methylation around transcription start sites (TSSs), while a positive correlation was observed in the gene body near TTSs. It was also possible that earlier demethylation of myogenic genes around TSSs contributes to their earlier expression in WZE. Using pyrosequencing to analyze DNA methylation patterns of promoter regions, we also found that earlier demethylation of the MyoD1 promoter in WZE contributed to its earlier expression. This study reveals that DNA demethylation of myogenic genes may contribute to embryonic leg muscle development differences between Wuzong and Shitou geese.

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Section: Discussionsupporting

confidence: 93%

DNA Demethylation of Myogenic Genes May Contribute to Embryonic Leg Muscle Development Differences between Wuzong and Shitou Geese

Zhang

Zhu

et al. 2023

IJMS

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“…37 In our study, dietary methionine supplementation increased the contents of SAM and methyltransferases and up-regulated the mRNA expression of DNMT1, DNMT3A and DNMT3B in ovarian tissue. SAM is the only intracellular methyl donor that participates in intracellular methylation processes, 38 and the deficiency of a methyl donor leads to reduced methylation levels in oocytes. 39,40 Alterations in DNA methylation profiles can alter gene expression profiles, leading to different phenotypes and potentially increased/decreased productivity and disease risk.…”

Section: Papermentioning

confidence: 99%

Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Yang,

Li,

Cai

et al. 2024

Food Funct.

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“…DNA methylation is catalyzed by DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B), which transfer the methyl group from S-adenosylmethionine (SAM) to the fifth carbon atom of cytosine residues, forming 5-methylcytosine (5mC) [52]. This modification is mainly present in CpG dinucleotides, while its presence in non-CpG environments is lower [53]. The process of DNA methylation is associated with the expression of the DNMT3 family of proteins [54] and is the basic mechanism for phenomena such as transposon silencing, X chromosome inactivation, and genomic imprinting [53].…”

Section: Dna Methylationmentioning

confidence: 99%

“…This modification is mainly present in CpG dinucleotides, while its presence in non-CpG environments is lower [53]. The process of DNA methylation is associated with the expression of the DNMT3 family of proteins [54] and is the basic mechanism for phenomena such as transposon silencing, X chromosome inactivation, and genomic imprinting [53]. DNA methylation is an important epigenetic modification that can affect gene expression without altering DNA sequences.…”

Section: Dna Methylationmentioning

confidence: 99%

Mechanistic Advances on Developmental Initiation, Maturation, and Ovulation of Oocytes in Domestic Cattle

Lan,

2023

Veterinary Medicine and Science

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With the continuous development of society, people’s demand for meat and milk continues to expand, especially beef and milk consumption. In order to improve the production efficiency of domestic cattle, frozen sperm, artificial fertilization, embryo transfer, and other reproductive technologies have been deeply studied and widely used, but the problem of beef and milk supply has not been fundamentally solved. The quality of oocytes is directly related to fertilization, embryo development, growth of fetal calf before and after birth, and its production performance. A thorough understanding of the mechanism of oocyte development initiation, maturation, and ovulation in domestic cattle will lay a theoretical foundation for us to further improve its production efficiency. This chapter focuses on summarizing and analyzing the recent progress of domestic cattle raising on the above issues and puts forward suggestions and prospects for future related work.

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DNA methylation studies in cattle

Cited by 11 publications

References 130 publications

DNA Demethylation of Myogenic Genes May Contribute to Embryonic Leg Muscle Development Differences between Wuzong and Shitou Geese

DNA Demethylation of Myogenic Genes May Contribute to Embryonic Leg Muscle Development Differences between Wuzong and Shitou Geese

Dietary methionine supplementation during the estrous cycle improves follicular development and estrogen synthesis in rats

Mechanistic Advances on Developmental Initiation, Maturation, and Ovulation of Oocytes in Domestic Cattle

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