DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients

Jadhav, Rohit R.; Santucci-Pereira, Julia; Wang, Yao V.; Liu, Joseph K.; Nguyen, Theresa D.; Wang, Jun; Jenkins, Sarah; Russo, José; Huang, Tim Hui-Ming; Jin, Victor X.; Lamartiniere, Coral A.

doi:10.3390/genes8050144

Cited by 35 publications

(22 citation statements)

References 55 publications

(120 reference statements)

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Section: Genistein and Daidzein Modulates Histone Modificationsmentioning

confidence: 99%

“…Results of another study in a breast cancer animal model suggested that genistein treatment decreased the carcinogenic activity bisphenol A (BPA), a high-volume chemical that is used in the manufacturing of polycarbonate plastics and containers for foods and beverages [87]. The genistein treatment decreased the BPA induced promoter methylation of different tumor suppressor genes in breast cancer [87]. Another study indicated that soy phytoestrogens such as genistein, daidzein, and equol lead to a reduction in trimethylation marks and an increase in acetylating marks of selected genes EZH2, BRCA1, ERα, ERβ, SRC3, and P300 [88].…”

Section: Genistein and Daidzein Modulates Histone Modificationsmentioning

confidence: 99%

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Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

et al. 2020

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Breast cancer is a common cancer that occurs due to different epigenetic alterations and genetic mutations. Various epidemiological studies have demonstrated an inverse correlation between breast cancer incidence and flavonoid intake. The anti-cancer action of flavonoids, a class of polyphenolic compounds that are present in plants, as secondary metabolites has been a major topic of research for many years. Our review analysis demonstrates that flavonoids exhibit anti-cancer activity against breast cancer occurring in different ethnic populations. Breast cancer subtype and menopausal status are the key factors in inducing the flavonoid’s anti-cancer action in breast cancer. The dose is another key factor, with research showing that approximately 10 mg/day of isoflavones is required to inhibit breast cancer occurrence. In addition, flavonoids also influence the epigenetic machinery in breast cancer, with research demonstrating that epigallocatechin, genistein, and resveratrol all inhibited DNA methyltransferase and altered chromatin modification in breast cancer. These flavonoids can induce the expression of different tumor suppressor genes that may contribute to decreasing breast cancer progression and metastasis. Additional studies are required to confirm the contribution of epigenetic modifications by flavonoids to breast cancer prevention.

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Section: Genistein and Daidzein Modulates Histone Modificationsmentioning

confidence: 99%

Section: Genistein and Daidzein Modulates Histone Modificationsmentioning

confidence: 99%

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

et al. 2020

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“…Comparison of genes that are epigenetically altered in the rat mammary gland to predict breast cancer patient survival using the Cancer Genomic Atlas (TCGA) revealed that two genes, HPSE and RPS9, were hypomethylated in the mammary gland of rats prepurtertally treated with GEN or GEN + BPA and were also associated with increased patient survival (104). These findings and the in vitro studies above provide strong evidence that at least in the mammary gland, GEN may induce beneficial DNA methylation and other epigenetic changes.…”

Section: Epigenetic Changes Induced By Phytoestrogens or Bacterial Mementioning

confidence: 99%

Effects of Phytoestrogens on the Developing Brain, Gut Microbiota, and Risk for Neurobehavioral Disorders

Rosenfeld

2019

Front. Nutr.

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Many pregnant and nursing women consume high amounts of soy and other plant products that contain phytoestrogens, such as genistein (GEN) and daidzein. Infants may also be provided soy based formulas. With their ability to bind and activate estrogen receptors (ESR) in the brain, such compounds can disrupt normal brain programming and lead to later neurobehavioral disruptions. However, other studies suggest that maternal consumption of soy and soy based formulas containing such phytoestrogens might lead to beneficial behavioral effects. Select gut microbes might also convert daidzein and to a lesser extent genistein to even more potent forms, e.g., equol derivatives. Thus, infant exposure to phytoestrogens may result in contrasting effects dependent upon the gut flora. It is also becoming apparent that consumption or exposure to these xenoestrogens may lead to gut dysbiosis. Phytoestrogen-induced changes in gut bacteria might in turn affect the brain through various mechanisms. This review will consider the evidence to date in rodent and other animal models and human epidemiological data as to whether developmental exposure to phytoestrogens, in particular genistein and daidzein, adversely or beneficially impact offspring neurobehavioral programming. Consideration will be given to potential mechanisms by which such compounds might affect neurobehavioral responses. A better understanding of effects perinatal exposure to phytoestrogen can exert on brain programming will permit pregnant women and those seeking to become pregnant to make better-educated choices. If phytoestrogen-induced gut dysbiosis contributes to neurobehavioral disruptions, remediation strategies may be designed to prevent such gut microbiota alterations and thereby improve neurobehavioral outcomes.

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“…Four genes were associated with a poor survival rate and eight were associated with a good survival rate. Among these genes, nine were hypermethylated in the distal region, indicating that their expression may be modified [ 62 ]. It should be noted that recent data suggest that BPA may act via ER-independent mechanisms including nuclear hormone receptors such as the thyroid hormone receptor, androgen receptor, and glucocorticoid receptor, but also with the orphan estrogen-related receptor gamma (ERRγ).…”

Section: Edcs and Breast Cancermentioning

confidence: 99%

Emerging Estrogenic Pollutants in the Aquatic Environment and Breast Cancer

Lecomte

Habauzit

Charlier

et al. 2017

Genes

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The number and amount of man-made chemicals present in the aquatic environment has increased considerably over the past 50 years. Among these contaminants, endocrine-disrupting chemicals (EDCs) represent a significant proportion. This family of compounds interferes with normal hormonal processes through multiple molecular pathways. They represent a potential risk for human and wildlife as they are suspected to be involved in the development of diseases including, but not limited to, reprotoxicity, metabolic disorders, and cancers. More precisely, several studies have suggested that the increase of breast cancers in industrialized countries is linked to exposure to EDCs, particularly estrogen-like compounds. Estrogen receptors alpha (ERα) and beta (ERβ) are the two main transducers of estrogen action and therefore important targets for these estrogen-like endocrine disrupters. More than 70% of human breast cancers are ERα-positive and estrogen-dependent, and their development and growth are not only influenced by endogenous estrogens but also likely by environmental estrogen-like endocrine disrupters. It is, therefore, of major importance to characterize the potential estrogenic activity from contaminated surface water and identify the molecules responsible for the hormonal effects. This information will help us understand how environmental contaminants can potentially impact the development of breast cancer and allow us to fix a maximal limit to the concentration of estrogen-like compounds that should be found in the environment. The aim of this review is to provide an overview of emerging estrogen-like compounds in the environment, sum up studies demonstrating their direct or indirect interactions with ERs, and link their presence to the development of breast cancer. Finally, we emphasize the use of in vitro and in vivo methods based on the zebrafish model to identify and characterize environmental estrogens.

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DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients

Cited by 35 publications

References 55 publications

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

Effects of Phytoestrogens on the Developing Brain, Gut Microbiota, and Risk for Neurobehavioral Disorders

Emerging Estrogenic Pollutants in the Aquatic Environment and Breast Cancer

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