DNA ploidy is a valuable predictor for prognosis of patients with resected renal cell carcinoma

Abou-Rebyeh, H.; Borgmann, V.; Nagel, R.; Al-Abadi, H.

doi:10.1002/1097-0142(20011101)92:9<2280::aid-cncr1574>3.0.co;2-2

Cited by 28 publications

(15 citation statements)

References 21 publications

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“…The strongest existing prognostic indicators for RCC are stage, grade, and Eastern Cooperative Oncology Group status (13,14). Among stage IV tumors, no clinical parameters have been identified that predict improved survival (15).…”

Section: Discussionmentioning

confidence: 99%

Predicting survival in patients with metastatic kidney cancer by gene-expression profiling in the primary tumor

Vasselli

Shih

Iyengar

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

161

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To identify potential molecular determinants of tumor biology and possible clinical outcomes, global gene-expression patterns were analyzed in the primary tumors of patients with metastatic renal cell cancer by using cDNA microarrays. We used grossly dissected tumor masses that included tumor, blood vessels, connective tissue, and infiltrating immune cells to obtain a gene-expression "profile" from each primary tumor. Two patterns of gene expression were found within this uniformly staged patient population, which correlated with a significant difference in overall survival between the two patient groups. Subsets of genes most significantly associated with survival were defined, and vascular cell adhesion molecule-1 (VCAM-1) was the gene most predictive for survival. Therefore, despite the complex biological nature of metastatic cancer, basic clinical behavior as defined by survival may be determined by the gene-expression patterns expressed within the compilation of primary gross tumor cells. We conclude that survival in patients with metastatic renal cell cancer can be correlated with the expression of various genes based solely on the expression profile in the primary kidney tumor.

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Section: Discussionmentioning

confidence: 99%

Predicting survival in patients with metastatic kidney cancer by gene-expression profiling in the primary tumor

Vasselli

Shih

Iyengar

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

161

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“…The predictive value of DNA ploidy in renal cell carcinoma has been shown in several studies 7,8 . A better prognosis, in terms of local recurrence, distant metastasis and survival rate, was noted for patients with a diploid DNA content compared with the non‐diploid pattern 7,8 . Ljungberg et al .…”

Section: Discussionmentioning

confidence: 95%

“…The DNA content in renal tumors has been investigated in many studies. However, its prognostic significance is still controversial 1,7–10 …”

Section: Discussionmentioning

confidence: 99%

“…DNA ploidy estimation differentiates diploid from aneuploid tumor cells according to regular or irregular DNA content. However, there is still controversy about the value of DNA ploidy in predicting disease progression and survival for patients who undergo nephrectomy due to RCC 1,7–10 …”

Section: Introductionmentioning

confidence: 99%

“…However, there is still controversy about the value of DNA ploidy in predicting disease progression and survival for patients who undergo nephrectomy due to RCC. 1,[7][8][9][10] The aim of the present study was to evaluate the expression of bcl-2 protein and DNA ploidy in renal cell adenocarcinoma to determine their association with established prognostic parameters and evaluate their role on predicting disease progression and cancerspecific survival.…”

Section: Introductionmentioning

confidence: 99%

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Bcl‐2 protein and DNA ploidy in renal cell carcinoma: Do they affect patient prognosis?

Skolarikos¹,

Alivizatos²,

Bamias

et al. 2005

Int J of Urology

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Aim : The aim of the present study was to correlate bcl-2 protein expression and DNA-ploidy status with established prognostic parameters in renal cell carcinoma (RCC) and to examine their impact on disease progression and patient survival. Methods : Both parameters were prospectively measured in 50 consecutive radical nephrectomy specimens using flow cytometry. They were correlated with the tumor grade, stage and histological type. Kaplan-Meier survival analysis for all parameters was performed.Results : Bcl-2 protein expression was higher in RCC compared to normal renal tissue ( P < 0.0001).Aneuploid tumors had higher bcl-2 expression compared to diploid tumors ( P = 0.015). Bcl-2 expression and DNA content were not correlated with tumor histological types ( P = 0.277/ P = 0.419), grades ( P = 0.690/ P = 0.449), T categories ( P = 0.637/ P = 0.585) or stages ( P = 0.726/ P = 0.800). Median follow-up time was 46 months (range, 5-84) with a mean overall survival of 61.8 months (95% confidence interval, 53.7-69.9). Tumor stage was the only statistically important prognostic factor ( P = 0.0045). Conclusion : Although Bcl-2 expression was correlated with tumor DNA content, the prognostic value of these two parameters following radical nephrectomy was not established.

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Prognostic Factors: Markers

Chung¹,

Libertino²

Renal Cell Cancer

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DNA ploidy is a valuable predictor for prognosis of patients with resected renal cell carcinoma

Cited by 28 publications

References 21 publications

Predicting survival in patients with metastatic kidney cancer by gene-expression profiling in the primary tumor

Predicting survival in patients with metastatic kidney cancer by gene-expression profiling in the primary tumor

Bcl‐2 protein and DNA ploidy in renal cell carcinoma: Do they affect patient prognosis?

Prognostic Factors: Markers

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