DNA polymerase activity in plasma from leukaemic guinea-pigs

Abstract

Summary.-Measurement of DNA polymerase in leukaemic guinea-pig plasma reveals the presence of low levels of sedimentable and non-sedimentable enzymic activities. Since the sedimentable DNA polymerase is ribonuclease sensitive, uses poly(C).oligo(dG) as template, and bands in a sucrose density gradient at 117 g/ml it is thought to be the GPLV-associated reverse transcriptase. The soluble DNA polymerase is stimulated by ribonuclease and is probably of cellular origin.