DNA/Protein binding and anticancer activity of Zn(II) complexes based on azo-Schiff base ligands

Synthesis of Zn(ii) coordination complexes, their molecular design and docking with SARS-CoV-2 RBD protein and Omicron spike protein

“…The DNA docking results of the Zn( ii ) complexes [Zn(L)(en)]ClO 4 ( 1 ) and [Zn(L) 2 ] ( 2 ) were comparable to those of Zn( ii ) complexes previously reported. 65–68…”

“…64 Moreover, both compounds showed high DNA affinity that was comparable with other Zn(II) complexes reported. [65][66][67][68] The fluorescence spectra of the Zn(II) complexes were recorded in MeOH at room temperature (Fig. S14 and S15, ESI †).…”

“…The DNA docking results of the Zn(II) complexes [Zn(L)(en)]ClO 4 (1) and [Zn(L) 2 ] (2) were comparable to those of Zn(II) complexes previously reported. [65][66][67][68] In vitro cytotoxicity activities Cytotoxicity assay with HEK-293 cell viability. The synthesized Zn(II) complexes showed good inhibition performance to the receptor binding domain (RBD) from the original SARS-CoV-2 and the Omicron spike (S) proteins, and thus could have potential as an antivirus drug candidate, so in vitro cytotoxicity studies of the Zn(II) complexes against the HEK-293 cell line and human PBMCs and haemolysis with erythrocytes were investigated using an MTT-based assay.…”

Are Zn(ii) pincer complexes efficient apoptosis inducers? a deep insight into their activity against A549 lung cancer cells

“…1–3 Among them, the activity of zinc complexes via different mechanisms has always attracted attention. 4 As an oligo-element with numerous biological functions, zinc has no negative side effects when taken in trace amounts. 5 In the past three decades, the development of various zinc complexes reported as anticancer agents has been witnessed.…”

In vitro anti-prostate adenocarcinoma and lung cancer studies of phenoxyaniline-block-poly(methyl methacrylate) based nanocomposites via controlled radical polymerization

“…In this direction, Kumar et al reported azo-Schiff base ligands like 2-(( E )-((4-(diethylamino)phenyl)imino)methyl)-4-(( E )-((2-phenylamino)phenyl)diazinyl)phenol containing Zn( ii ) complexes, which have been analyzed for their effective cytotoxicity properties against the Hut-78 cell line. 3 Hosseini et al also reported a doxorubicin-based bentonite nanoclay complex and used it to treat melanoma cells, which showed effective targeted drug delivery properties. 4 Generally, nanoparticulate clay, which we used in anti-cancer treatment, has drawn great attention as a drug carrier due to their better bio-compatibility, high specific surface area and high adsorption behavior.…”