DNA repair gene ERCC1 polymorphisms may contribute to the risk of glioma

Abstract

Polymorphisms in excision repair cross-complementing rodent repair deficiency complementation group 1 (ERCC1) gene have been shown to affect individual susceptibility to glioma, though studies have yielded conflicting results. This meta-analysis aims to derive a more precise estimation of the association between ERCC1 C8092A and C118T polymorphisms and glioma risk. A literature search of PubMed, Embase, Web of Science, Cochrane Library, and CBM databases was conducted to identify all eligible studies published before August 5, 2013. Crude odds ratios (ORs) with their corresponding confidence intervals (95% CIs) were used to assess the strength of this association. A meta-analysis was performed by reviewing seven studies on the C8092A polymorphism (2,978 cases and 4,051 controls) and four studies on the C118T polymorphism (1,390 Asian cases and 1,546 Asian controls). Pooled analysis yielded a significant association between the C8092A variant genotype and increased risk of glioma. As for ethnicity, the A allele was associated with increased risk of glioma in Asians, while no similar finding was observed in Caucasians. Stratified analyses by histological subtype indicated that the C8092A polymorphism showed a significant association with the risk of non-glioblastoma multiforme. For the C118T polymorphism, increased glioma susceptibility was also observed among Asians. Taken together, results from our meta-analysis support the view that common variants in ERCC1 may contribute to susceptibility to glioma, especially in Asians. However, further studies investigating the significance of these two polymorphisms as markers of susceptibility to and disease progression of glioma are still needed.

A Comprehensive Analysis of Influence ERCC Polymorphisms Confer on the Development of Brain Tumors

“…Almost at the same time, Yuan et al associated rs11615 and rs3212986 with glioma and observed a main effect particularly in Asian [45]. The rs3212986 association was also replicated in another metaanalysis where multiple DNA repair genes were included [46].…”

ERCC2 rs13181 polymorphism association with glioma susceptibility in a Chinese population

“…Genetic factors, such as single nucleotide polymorphisms (SNPs), play an important role in modifying glioma susceptibility, such as SNPS in XRCC1, ERCC1, interleukin-8, and VEGF genes (Jiang et al, 2013;Yuan et al, 2014;Liu et al, 2015;Wang et al, 2015). The rs13181 polymorphism of ERCC2 is a T to G substitution at the 751 locus, which may alter the enzymatic activity of the encoded protein.…”

Role of single nucleotide polymorphisms of DNA repair genes in susceptibility to pancreatic cancer in Chinese population

“…Zhu et al (2014) conducted a meta-analysis with 11 case-control studies, but they did not find any association between the ERCC1 rs3212986 polymorphism and development of lung cancer. Yuan et al (2014) also conducted a meta-analysis with seven studies, and reported that the ERCC1 rs3212986 polymorphism correlated with the risk of non-glioblastoma multiforme. The association between the ERCC1 rs3212986 polymorphism and the risk of pancreatic cancer has been reported in only one previous study (McWilliams et al, 2008).…”