DNA repair gene XRCC7 polymorphisms (rs#7003908 and rs#10109984) and hepatocellular carcinoma related to AFB1 exposure among Guangxi population, China

Long, Xi-Dai; Yao, Jin-Guang; Huang, Yongzhi; Huang, Xiaoying; Ban, Fu-Zhi; Yao, Liming; Fan, Lu-Dan

doi:10.1111/j.1872-034x.2011.00866.x

Cited by 28 publications

(25 citation statements)

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“…In Guangxi area, several reports imply XRCC7 rs7003908 polymorphism (T to G) may be associated with HCC related to AFB1 exposure [49,94]. Through a hospital-based case-control study (including 348 cases with HCC and 597 age-, gender-, race-, and hepatitis viruses-matched healthy controls) conducted in high AFB1 exposure area from Guangxi, Long et al [94] investigated the association between XRCC7 rs7003908 polymorphism and HCC risk and found signiicantly diferent distribution of three genotypes (rs7003908-TT, -TG, and -GG) between cases and controls (25. ) [49].…”

Section: The Xrcc7 Gsnps and Afb1-hcc Among Guangxiese Populationmentioning

confidence: 99%

Genetic Single Nucleotide Polymorphisms (GSNPs) in the DNA Repair Genes and Hepatocellular Carcinoma Related to Aflatoxin B1 among Guangxiese Population

Wu¹,

Xi²,

Lü³

et al. 2017

Genetic Polymorphisms

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Alatoxin B1 (AFB1) is an important environmental carcinogen for the development of hepatocellular carcinoma (HCC). HCC is a complex disease likely resulting from genetic single nucleotide polymorphisms (GSNPs) of multiple interacting genes and geneenvironment interactions. Recent eforts have been made to analyze the associations between risk of this malignancy and GSNPs in genes involved in the repair of DNA damage induced by AFB1. Here, we reviewed the results of published case-control studies that have examined the efects of common alleles of all susceptible DNA repair genes, including XRCC1, XRCC3, XRCC4, XRCC7, XPC, and XPD, on risk of AFB1-related HCC among Guangxi population. Statistically signiicant diferences in genotype frequencies found in case-control comparisons were rs25487, rs80309960, rs861539, rs7003908, rs28383151, rs3734091, rs13181, and rs2228001 polymorphism. The overall efects of these GNSPs were moderate in terms of relative risk, with ORs ranging from 2 to 10. Furthermore, some evidence of the interaction of GSNPs in DNA repair genes and AFB1 exposure modulate risk of this cancer was also found, although the results require conirmation with larger sample size studies.

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Section: The Xrcc7 Gsnps and Afb1-hcc Among Guangxiese Populationmentioning

confidence: 99%

Genetic Single Nucleotide Polymorphisms (GSNPs) in the DNA Repair Genes and Hepatocellular Carcinoma Related to Aflatoxin B1 among Guangxiese Population

Wu¹,

Xi²,

Lü³

et al. 2017

Genetic Polymorphisms

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“…More than one hundred polymorphisms have been reported in the XRCC7 gene (dbSNP in NCBI database), some of which are correlated with malignant tumors such as liver cancer [16, 17, 31]. In the present study, we only analyzed XRCC7P, primarily because several studies have shown that this polymorphism may influence the expression of XRCC7 gene and consequently increase the risk of cancers, such as liver, bladder, and prostate cancer [15, 17, 32, 33].…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, we only analyzed XRCC7P, primarily because several studies have shown that this polymorphism may influence the expression of XRCC7 gene and consequently increase the risk of cancers, such as liver, bladder, and prostate cancer [15, 17, 32, 33]. For example, Long et al investigated the risk effects of XRCC7P on hepatocellular carcinoma (HCC) and found that these individuals carrying XRCC7-GG would face higher cancer risk than those with XRCC7-TT (adjusted OR = 5.04, P < 0.001) [17]. Similarly, Mandal et al and Wang et al also found that this polymorphism might modify the risk of prostate cancer and bladder cancer [32, 33].…”

Section: Discussionmentioning

confidence: 99%

“…DNA was extracted from noncancerous gastric biopsy tissues from all cancer patients and control subjects according to the previously described methods [17]. XRCC7 (rs#7003908) genotypes were tested by using the TaqMan-PCR on iCycler iQ real-time PCR detection system (CFX Manager Version 2, Bio-Rad).…”

Section: Methodsmentioning

confidence: 99%

“…Recently, several studies have shown that XRCC7 rs#7003908 polymorphism (XRCC7P) may be associated with DNA repair capacity and tumor risk [15–17]. However, the association between this polymorphism and GAA has not yet been elucidated.…”

Section: Introductionmentioning

confidence: 99%

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XRCC7 rs#7003908 Polymorphism andHelicobacter pyloriInfection-Related Gastric Antrum Adenocarcinoma

Wang

Huang²,

Yao³

et al. 2013

International Journal of Genomics

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The X-ray repair cross-complementing group 7 (XRCC7) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. To determine whether XRCC7 rs#7003908 polymorphism (XRCC7P) is associated with Helicobacter pylori (H. pylori) infection-related gastric antrum adenocarcinoma (GAA) risk, we conducted a hospital-based case-control study, including 642 patients with pathologically confirmed GAA and 927 individually matched controls without any evidence of tumours or precancerous lesions, among Guangxi population. Increased risks of GAA were observed for individuals with cagA positive (odds ratio (OR) 6.38; 95% confidence interval (CI) 5.03–8.09). We also found that these individuals with the genotypes of XRCC7 rs#7003908 G alleles (XRCC7-TG or -GG) featured increasing risk of GAA (ORs 2.80 and 5.13, resp.), compared with the homozygote of XRCC7 rs#7003908 T alleles (XRCC7-TT). GAA risk, moreover, did appear to differ more significantly among individuals featuring cagA-positive status, whose adjusted ORs (95% CIs) were 15.74 (10.89–22.77) for XRCC7-TG and 38.49 (22.82–64.93) for XRCC7-GG, respectively. Additionally, this polymorphism multiplicatively interacted with XRCC3 codon 241 polymorphism with respect to HCC risk (ORinteraction = 1.49). These results suggest that XRCC7P may be associated with the risk of Guangxiese GAA related to cagA.

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Harnessing the cooperation between DNA‐PK and cGAS in cancer therapies

et al. 2023

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The cyclic GMP‐AMP synthase–stimulator of interferon genes (cGAS‐STING) pathway is central for the initiation of anti‐tumoural immune responses. Enormous effort has been made to optimise the design and administration of STING agonists to stimulate tumour immunogenicity. However, in certain contexts the cGAS‐STING axis fuels tumourigenesis. Here, we review recent findings on the regulation of cGAS expression and activity. We particularly focus our attention on the DNA‐dependent protein kinase (DNA‐PK) complex, that recently emerged as an activator of inflammatory responses in tumour cells. We propose that stratification analyses on cGAS and DNA‐PK expression/activation status should be carried out to predict treatment efficacy. We herein also provide insights into non‐canonical functions borne by cGAS and cGAMP, highlighting how they may influence tumourigenesis. All these parameters should be taken into consideration concertedly to choose strategies aiming to effectively boost tumour immunogenicity.

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DNA repair gene XRCC7 polymorphisms (rs#7003908 and rs#10109984) and hepatocellular carcinoma related to AFB1 exposure among Guangxi population, China

Abstract: These data suggest that XRCC7 rs#7003908 polymorphism may be one of the genetic modifiers for AFB1-related HCC among Guangxi population.

Cited by 28 publications

References 29 publications

Genetic Single Nucleotide Polymorphisms (GSNPs) in the DNA Repair Genes and Hepatocellular Carcinoma Related to Aflatoxin B1 among Guangxiese Population

Genetic Single Nucleotide Polymorphisms (GSNPs) in the DNA Repair Genes and Hepatocellular Carcinoma Related to Aflatoxin B1 among Guangxiese Population

XRCC7 rs#7003908 Polymorphism andHelicobacter pyloriInfection-Related Gastric Antrum Adenocarcinoma

Harnessing the cooperation between DNA‐PK and cGAS in cancer therapies

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