DNA strand breaks based on Monte Carlo simulation in and around the Lipiodol with flattening filter and flattening filter-free photon beams

Kawahara, Daisuke; Saito, A.; Nakano, Hisashi; Nagata, Yasushi

doi:10.5603/rpor.a2022.0067

Cited by 1 publication

(1 citation statement)

References 49 publications

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“…However, the past modellings which consider chemical processes and DNA structure need a long calculation time. Recently, DNA damage estimation is getting more and more attention in the field of medical physics (Nakano et al 2021, Saito et al 2022. In order to reduce computing time, simplified models of evaluating DNA damage induction are of interest.…”

Section: Introductionmentioning

confidence: 99%

Application of a simple DNA damage model developed for electrons to proton irradiation

Matsuya¹,

Kai²,

Parisi³

et al. 2022

Phys. Med. Biol.

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Proton beam therapy allows irradiating tumor volumes with reduced side effects on normal tissues with respect to conventional X-ray radiotherapy. Biological effects such as cell killing after proton beam irradiations depend on the proton kinetic energy, which is intrinsically related to early DNA damage induction. As such, DNA damage estimation based on Monte Carlo simulations is a research topic of worldwide interest. Such simulation is a mean of investigating the mechanisms of DNA strand break formations. However, past modellings considering chemical processes and DNA structures require long calculation times. Particle and Heavy Ion Transport System (PHITS) is one of the general-purpose Monte Carlo codes that can simulate track structure of protons, meanwhile cannot handle radical dynamics simulation in liquid water. It also includes a simple model enabling the efficient estimation of DNA damage yields only from the spatial distribution of ionizations and excitations without DNA geometry, which was originally developed for electron track-structure simulations. In this study, we investigated the potential application of the model to protons without any modification. The yields of single-strand breaks, double-strand breaks (DSBs) and the complex DSBs were assessed as functions of the proton kinetic energy. The PHITS-based estimation showed that the DSB yields increased as the linear energy transfer (LET) increased, and reproduced the experimental and simulated yields of various DNA damage types induced by protons with LET up to about 30 keV/μm. These results suggest that the current DNA damage model implemented in PHITS is sufficient for estimating DNA lesion yields induced after protons irradiation except at very low energies (below 1 MeV). This model contributes to evaluating early biological impacts in radiation therapy.

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Section: Introductionmentioning

confidence: 99%

Application of a simple DNA damage model developed for electrons to proton irradiation

Matsuya¹,

Kai²,

Parisi³

et al. 2022

Phys. Med. Biol.

View full text Add to dashboard Cite

show abstract

DNA strand breaks based on Monte Carlo simulation in and around the Lipiodol with flattening filter and flattening filter-free photon beams

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited.

Cited by 1 publication

References 49 publications

Application of a simple DNA damage model developed for electrons to proton irradiation

Application of a simple DNA damage model developed for electrons to proton irradiation

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