DNA-Templated Ordered Array of Gold Nanorods in One and Two Dimensions

Pan, Bifeng; Cui, Daxiang; Ozkan, Cengiz S.; Xu, Ping; Huang, Tuo; Li, Qing; Chen, Hao; Liu, Fengtao; Gao, Feng; He, Rong

doi:10.1021/jp072335+

Cited by 71 publications

(66 citation statements)

References 26 publications

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“…It is consistent with the previous reports that the longitudinal band of GNRs is more sensitive to the local environment around GNRs than the transverse band [42][43][44][45]. This result suggested that the aggregation of GNRs takes place in a side-by-side manner [46,47].…”

Section: +supporting

confidence: 93%

Colorimetric assay of lead using unmodified gold nanorods

et al. 2012

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Lead poisoning in adults can affect the peripheral and central nervous systems, the kidneys, and blood pressure. Thus, the development of environment-friendly and simple methods for Pb 2+ detection is of great importance. Herein, a label-free colorimetric method has been developed for the detection of Pb 2+ based on the conformational switch from single-stranded DNA to G-quadruplex. The electrostatic interactions between DNA probe and gold nanorods (GNRs) induce GNRs to space closely. However, the electrostatic interaction is not strong enough to change the suspension state of GNRs. In the presence of Pb 2+ , the formation of G-quadruplexes increases the surface charge density around DNA, which is expected to strengthen the electrostatic interaction between the GNRs and the DNA. Therefore, the longitudinal absorption of GNRs decreased because the stronger interaction induced aggregation of GNRs. Importantly, the decrease in longitudinal absorption is proportional to concentration of Pb 2+ . By monitoring the change of absorbance, Pb 2+ can be detected at a level of 3 nM with a linear range from 5 nM to 1 μM. The overall test only takes a few minutes and very little interference is observed from other metal ions. The major advantages of this method are its low cost, convenience, simplicity, sensitivity, and specificity.

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Section: +supporting

confidence: 93%

Colorimetric assay of lead using unmodified gold nanorods

et al. 2012

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“…Plasmonic Au@Ag nanorods were prepared by using our previous modified method [14,40]. The synthesis procedure is shown in Fig.…”

Section: Preparation and Characterization Of Au@ag Nanorodsmentioning

confidence: 99%

EGFR Antibody Conjugated Bimetallic Au@Ag Nanorods for Enhanced SERS-Based Tumor Boundary Identification, Targeted Photoacoustic Imaging and Photothermal Therapy

Chen¹,

Zhang²,

Yang³

et al. 2016

Nano BioMed ENG

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The development of multifunctional nanoprobes for simultaneous targeted imaging, tumor boundary identification and photothermal therapy of gastric cancer has become a great challenge. Herein, EGFR monoclonal antibody-conjugated Au@Ag nanorods decorated with DTNB nanoprobes (5,5'-Dithiobis-(2-nitrobenzoic acid)) (EGFR-Au@Ag NR nanotags) were prepared and characterized. Their biocompatibility was analyzed by MTT assay. In vitro studies show that EGFR-Au@Ag NR nanotags own good biocompatibility and capability of targeting and entering into gastric cancer MGC803 cells, silver nano-film layer on the surface of gold nanorods remarkably enhance surfaceenhanced rama spectra (SERS) signal, enhanced photoacoustic imaging efficacy and photothermal conversion efficiency of gold nanorods. In vivo studies show that prepared nanotags could target actively gastric cancer cells at 2 h post-injection, and distributed in the tumor site, exhibited enhanced SERS signals to display clearly tumor boundary, enhanced photoacoustic imaging to display clearly tumor boundary. Under 1 w/cm 2 laser irradiation, tumor growth was remarkably inhibited by local photothermal therapy. In conclusion, high performance EGFR-antibody conjugated Au@Ag nanorod-DTNB nanoprobes exhibit great potential in applications such as targeted photoacoustic imaging, simultaneous tumor boundary identification and selective photothermal therapy of gastric cancer in the near future.

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“…12 Given the advanced state of their production, most recent experimental work on gold nanorods has focused on further manipulation of their surface chemistry, [13][14][15][16][17][18][19][20][21][22][23][24] formation of complex assemblies, [25][26][27][28][29][30][31][32][33] and development of biomedical and sensing applications.…”

mentioning

confidence: 99%

Shape-dependent plasmon resonances of gold nanoparticles

2008

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Localized surface plasmon resonances in noble metal nanoparticles cause enhanced optical absorption and scattering that is tunable through the visible and near-infrared. Furthermore, these resonances create large local electric field enhancements at the nanoparticle surfaces, essentially focussing light at the nanometer scale. These properties suggest a range of applications, including biomedical imaging, therapeutics, and molecular sensing. Here we review some recent advances regarding shape-dependent optical properties of two specific nanoparticle geometries: gold nanorods and branched gold nanoparticles.

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DNA-Templated Ordered Array of Gold Nanorods in One and Two Dimensions

Cited by 71 publications

References 26 publications

Colorimetric assay of lead using unmodified gold nanorods

Colorimetric assay of lead using unmodified gold nanorods

EGFR Antibody Conjugated Bimetallic Au@Ag Nanorods for Enhanced SERS-Based Tumor Boundary Identification, Targeted Photoacoustic Imaging and Photothermal Therapy

Shape-dependent plasmon resonances of gold nanoparticles

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