DNQX blockade of amphetamine behavioral sensitization

Karler, Ralph; Calder, Larry D.; Turkanis, Stuart A.

doi:10.1016/0006-8993(91)90095-d

Cited by 162 publications

(79 citation statements)

References 23 publications

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“…Infusing AMPA into the NAcc produces enhanced locomotion in rats exposed to cocaine 2-3 weeks earlier (Bell and Kalivas, 1996;Pierce et al, 1996a) and AMPA receptor antagonists prevent the expression of locomotor sensitization by amphetamine (Karler et al, 1991;Tzschentke and Schmidt, 1997;Mead and Stephens, 1998;cf, Li et al, 1997) and cocaine (Pierce et al, 1996a;Jackson et al, 1998;Bell et al, 2000;cf, Karler et al, 1994;Li et al, 1997). The present results are consistent with these findings and extend them to the reinstatement of drug seeking.…”

Section: Discussionsupporting

confidence: 87%

“…For example, infusions of AMPA into the NAcc produce enhanced locomotion in animals exposed to cocaine 2-3 weeks earlier (Bell and Kalivas, 1996;Pierce et al, 1996a) and AMPA receptor antagonists administered systemically (Karler et al, 1991;Tzschentke and Schmidt, 1997;Jackson et al, 1998;Mead and Stephens, 1998;cf, Karler et al, 1994;Li et al, 1997) or into the NAcc (Pierce et al, 1996a;Bell et al, 2000) prevent the expression of locomotor sensitization by amphetamine (AMPH) and cocaine. When taken in light of the above findings and others showing that sensitization enhances the pursuit and self-administration of drugs (Vezina, 2004), these results suggest that previous exposure to psychostimulants should enhance the ability of NAcc AMPA to reinstate drug seeking.…”

Section: Introductionmentioning

confidence: 99%

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Previous Exposure to Psychostimulants Enhances the Reinstatement of Cocaine Seeking by Nucleus Accumbens AMPA

Suto

Tanabe

Austin

et al. 2004

Neuropsychopharmacol

103

100

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The effect of previous exposure to psychostimulants on the subsequent self-administration of cocaine as well as reinstatement of this behavior by priming infusions of AMPA into the nucleus accumbens (NAcc) was examined. Rats were exposed to five injections, one injection every third day, of either saline or amphetamine (AMPH: 1.5 mg/kg, i.p.). Starting 10 days later, they were trained to selfadminister cocaine (0.3 mg/kg/infusion, i.v.) and subsequently tested under a progressive ratio (PR) schedule for 4 consecutive days. As expected, rats exposed to AMPH worked more and obtained more cocaine infusions than saline exposed controls on the PR test sessions. Following daily extinction sessions during which saline was substituted for cocaine, the effect of priming infusions of AMPA (0.0, 0.08, or 0.8 nmol/0.5 ml/side) into the NAcc was then examined on two tests: one conducted 4 days after the last cocaine PR test session (2-3 weeks after the last AMPH exposure injection) and the next 4 weeks later. Consistent with previous reports, NAcc AMPA dosedependently reinstated cocaine seeking on both tests regardless of exposure condition. Importantly, this priming effect of NAcc AMPA was significantly enhanced in AMPH compared to saline exposed rats on the first test conducted 2-3 weeks after AMPH. On the second test, conducted 4 weeks after cocaine, reinstatement was similarly enhanced in both groups to levels observed on the first test in AMPH exposed rats. These results indicate that both noncontingent (AMPH) and contingent (cocaine) exposure to psychostimulants enhances the reinstatement of cocaine seeking by NAcc AMPA and appears to do so in a time-dependent manner.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Previous Exposure to Psychostimulants Enhances the Reinstatement of Cocaine Seeking by Nucleus Accumbens AMPA

Suto

Tanabe

Austin

et al. 2004

Neuropsychopharmacol

103

100

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“…The systemic administration of either NMDA (Karler et al, 1989;Wolf et al, 1995) or AMPA/kainate (Karler et al, 1991a;Li et al, 1997;cf Akiyama et al, 1998) receptor antagonists as well as the application into the VTA of either NMDA (Cador et al, 1999;Vezina and Queen, 2000) or mGlu (Kim and Vezina, 1998) receptor antagonists has been shown to prevent the induction of AMPH-induced locomotor sensitization. Moreover, systemically administering NMDA receptor antagonists with AMPH during preexposure also prevents cellular correlates of locomotor Figure 6 Injection cannula tip placements in the VTA.…”

Section: Induction Of Sensitization By Amph Requires Activation Of Glmentioning

confidence: 99%

“…Indeed, induction of locomotor sensitization by AMPH has been shown to be dependent on activation of Nmethyl-D-aspartate (NMDA: Cador et al, 1999;Vezina and Queen, 2000) and metabotropic glutamate (mGlu: Kim and Vezina, 1998) receptors in the VTA. Systemic administration of NMDA (Karler et al, 1989;Wolf et al, 1995) or a-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA)/kainate receptor antagonists (Karler et al, 1991a;Li et al, 1997) also prevents the development of locomotor sensitization by systemic AMPH. Moreover, induction of locomotor sensitization by AMPH is blocked by lesions of the PFC, which provides major glutamatergic afferentation to the VTA Cador et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Previous Exposure to VTA Amphetamine Enhances Cocaine Self-Administration under a Progressive Ratio Schedule in an NMDA, AMPA/Kainate, and Metabotropic Glutamate Receptor-Dependent Manner

Suto

Tanabe

Austin

et al. 2003

Neuropsychopharmacol

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Previous exposure to amphetamine (AMPH) in the ventral tegmental area (VTA) enhances cocaine self-administration in a D 1 dopamine receptor-dependent manner. The present study examined the contribution of VTA NMDA, AMPA/kainate, and metabotropic glutamate (mGlu) receptors to this effect. Rats in different groups received three intra-VTA injections, one every third day, of either saline (0.5 ml/ side), AMPH (2.5 mg/0.5 ml/side), AMPH+CPP (NMDA receptor antagonist; 10 mM or 100 mM/0.5 ml/side), AMPH+CNQX (AMPA/ kainate receptor antagonist; 0.3 mM or 1 mM/0.5 ml/side), AMPH+MCPG (mGlu receptor antagonist; 0.5 mM or 50 mM/0.5 ml/side), or the glutamate receptor antagonists alone. Starting 7-10 days after the last pre-exposure injection, rats were trained to self-administer cocaine (0.3 mg/kg/infusion) and then tested under a progressive ratio (PR) schedule of reinforcement for 6 consecutive days. As reported previously, VTA AMPH pre-exposed rats worked more and obtained more infusions of cocaine than saline pre-exposed animals. Coadministration of CPP, CNQX, or MCPG with AMPH during pre-exposure dose-dependently blocked this enhancement of cocaine self-administration. Rats pre-exposed to the glutamate receptor antagonists alone did not differ on the test days from the saline pre-exposed controls. These results indicate that, in a manner paralleling the induction of sensitization of the locomotor stimulating effects of AMPH, activation of NMDA, AMPA/kainate, and mGlu receptors during pre-exposure to AMPH in the VTA is necessary for the enhancement of cocaine self-administration to develop.

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“…A glutamate-DA interaction is an important dynamic in the expression of behavioral sensitization in the NAS. Glutamate increases the release of DA in the NAS (Kalivas 1995;Kalivas & Stewart 1991), and motor activity elicited by injection of either DA or glutamate agonists into the NAS is diminished by coadministration of antagonists to the other neurotransmitter (Bell & Kalivas 1996;Kalivas 1995;Karler et al 1991;. NAS neurons also show enhanced responsiveness to glutamate in sensitized states that may be related to glutamate receptor adaptations observed in the NAS (Lu et al 1997;Nestler & Aghajanian 1997;Pierce et al 1996a;Zhang et al 1997).…”

Section: Experience-dependent Processesmentioning

confidence: 99%

Steps to a neurochemistry of personality

Lawrence¹,

Koepp²,

Gunn³

et al. 1999

Behav Brain Sci

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Extraversion has two central characteristics: (1) interpersonal engagement, which consists of affiliation (enjoying and valuing close interpersonal bonds, being warm and affectionate) and agency (being socially dominant, enjoying leadership roles, being assertive, being exhibitionistic, and having a sense of potency in accomplishing goals) and (2) impulsivity, which emerges from the interaction of extraversion and a second, independent trait (constraint). Agency is a more general motivational disposition that includes dominance, ambition, mastery, efficacy, and achievement. Positive affect (a combination of positive feelings and motivation) is closely associated with extraversion. Extraversion is accordingly based on positive incentive motivation.Parallels between extraversion (particularly its agency component) and a mammalian behavioral approach system based on positive incentive motivation implicate a neuroanatomical network and modulatory neurotransmitters in the processing of incentive motivation. A corticolimbic-striatal-thalamic network (1) integrates the salient incentive context in the medial orbital cortex, amygdala, and hippocampus; (2) encodes the intensity of incentive stimuli in a motive circuit composed of the nucleus accumbens, ventral pallidum, and ventral tegmental area dopamine projection system; and (3) creates an incentive motivational state that can be transmitted to the motor system.Individual differences in the functioning of this network arise from functional variation in the ventral tegmental area dopamine projections, which are directly involved in coding the intensity of incentive motivation. The animal evidence suggests that there are three neurodevelopmental sources of individual differences in dopamine: genetic, "experience-expectant," and "experience-dependent." Individual differences in dopamine promote variation in the heterosynaptic plasticity that enhances the connection between incentive context and incentive motivation and behavior.Our psychobiological threshold model explains the effects of individual differences in dopamine transmission on behavior, and their relation to personality traits is discussed.Keywords: behavioral sensitization; dopamine; extraversion; heterosynaptic plasticity; incentive motivation; neurobiology; personality the behavioral, emotional, and motivational characteristics of extraversion. Next, we identified a mammalian behavior pattern with corresponding characteristics, as described in the psychological and ethological literatures. Once an analogous motivation was identified, animal neurobiological research provided empirical links to its neural organization and neurochemical modulation. These hypotheses were then extended to humans and subjected to empirical tests. Extraversion: Central characteristics and underlying motivationExtraversion is a higher-order trait that is derived from a set of correlated lower-order traits. The lower-order traits are measures of behavioral and emotional characteristicssuch as social dominance, positive emo...

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DNQX blockade of amphetamine behavioral sensitization

Cited by 162 publications

References 23 publications

Previous Exposure to Psychostimulants Enhances the Reinstatement of Cocaine Seeking by Nucleus Accumbens AMPA

Previous Exposure to Psychostimulants Enhances the Reinstatement of Cocaine Seeking by Nucleus Accumbens AMPA

Previous Exposure to VTA Amphetamine Enhances Cocaine Self-Administration under a Progressive Ratio Schedule in an NMDA, AMPA/Kainate, and Metabotropic Glutamate Receptor-Dependent Manner

Steps to a neurochemistry of personality

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